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Preparation of the albumin nanoparticle system loaded with both paclitaxel and sorafenib and its evaluation in vitro and in vivo
Zhang, Jin-Yang; He, Bing; Qu, Wei; Cui, Zheng; Wang, Yi-bo; Zhang, Hua; Wang, Jian-Cheng; Zhang, Qiang
关键词paclitaxel sorafenib albumin nanoparticles combination therapy toxicity antitumour effect
刊名JOURNAL OF MICROENCAPSULATION
2011
DOI10.3109/02652048.2011.590614
28期:6页:528-536
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
资助者National Basic Research Program of China ; State Key Projects ; 863 Project ; National Basic Research Program of China ; State Key Projects ; 863 Project
研究领域[WOS]Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]CELL LUNG-CARCINOMA ; TUMOR ANGIOGENESIS ; CANCER ; CHEMOTHERAPY ; COMBINATION ; INHIBITORS ; HEMOLYSIS ; PATHWAY ; ETHANOL
英文摘要

Paclitaxel and sorafenib loaded albumin nanoparticles (PTX-SRF-BSA-NPs) were prepared and studied here to avoid the toxicities from the excipients in the Taxol (R) and explore the effect of such combination on the antitumour efficacy and toxicity. PTX-BSA-NPs and so on were used as controls. The particle size, zeta potential, encapsulation efficiency and morphology were evaluated. Less than 70% of each drug released within 24 h. PTX and SRF existed as molecular or amorphous form in the PTX-SRF-BSA-NPs. The particle size did not change much after 2-month storage in freeze-dried form or 24 h in suspension. The treatment with PTX-SRF-BSA-NPs (7.5mgkg(-1) PTX + 7.5mgkg(-1) SRF) exhibited lower myelosuppression than PTX-BSA-NPs (15mgkg(-1) PTX) while it remained or increased the antitumour effect in mice tumour models. Compared with the solution containing the same level of PTX and SRF, PTX-SRF-BSA-NPs demonstrated significantly lower haemolysis and myelosuppression effect.

语种英语
所属项目编号2009CB930300 ; 2009ZX09310 ; 2007AA021811
资助者National Basic Research Program of China ; State Key Projects ; 863 Project ; National Basic Research Program of China ; State Key Projects ; 863 Project
WOS记录号WOS:000293744700008
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64531
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jin-Yang,He, Bing,Qu, Wei,et al. Preparation of the albumin nanoparticle system loaded with both paclitaxel and sorafenib and its evaluation in vitro and in vivo[J]. JOURNAL OF MICROENCAPSULATION,2011,28(6):528-536.
APA Zhang, Jin-Yang.,He, Bing.,Qu, Wei.,Cui, Zheng.,Wang, Yi-bo.,...&Zhang, Qiang.(2011).Preparation of the albumin nanoparticle system loaded with both paclitaxel and sorafenib and its evaluation in vitro and in vivo.JOURNAL OF MICROENCAPSULATION,28(6),528-536.
MLA Zhang, Jin-Yang,et al."Preparation of the albumin nanoparticle system loaded with both paclitaxel and sorafenib and its evaluation in vitro and in vivo".JOURNAL OF MICROENCAPSULATION 28.6(2011):528-536.
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