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学科主题: 药学
题名:
Preparation of the albumin nanoparticle system loaded with both paclitaxel and sorafenib and its evaluation in vitro and in vivo
作者: Zhang, Jin-Yang; He, Bing; Qu, Wei; Cui, Zheng; Wang, Yi-bo; Zhang, Hua; Wang, Jian-Cheng; Zhang, Qiang
关键词: paclitaxel ; sorafenib ; albumin nanoparticles ; combination therapy ; toxicity ; antitumour effect
刊名: JOURNAL OF MICROENCAPSULATION
发表日期: 2011
DOI: 10.3109/02652048.2011.590614
卷: 28, 期:6, 页:528-536
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]: CELL LUNG-CARCINOMA ; TUMOR ANGIOGENESIS ; CANCER ; CHEMOTHERAPY ; COMBINATION ; INHIBITORS ; HEMOLYSIS ; PATHWAY ; ETHANOL
英文摘要:

Paclitaxel and sorafenib loaded albumin nanoparticles (PTX-SRF-BSA-NPs) were prepared and studied here to avoid the toxicities from the excipients in the Taxol (R) and explore the effect of such combination on the antitumour efficacy and toxicity. PTX-BSA-NPs and so on were used as controls. The particle size, zeta potential, encapsulation efficiency and morphology were evaluated. Less than 70% of each drug released within 24 h. PTX and SRF existed as molecular or amorphous form in the PTX-SRF-BSA-NPs. The particle size did not change much after 2-month storage in freeze-dried form or 24 h in suspension. The treatment with PTX-SRF-BSA-NPs (7.5mgkg(-1) PTX + 7.5mgkg(-1) SRF) exhibited lower myelosuppression than PTX-BSA-NPs (15mgkg(-1) PTX) while it remained or increased the antitumour effect in mice tumour models. Compared with the solution containing the same level of PTX and SRF, PTX-SRF-BSA-NPs demonstrated significantly lower haemolysis and myelosuppression effect.

语种: 英语
所属项目编号: 2009CB930300 ; 2009ZX09310 ; 2007AA021811
项目资助者: National Basic Research Program of China ; State Key Projects ; 863 Project
WOS记录号: WOS:000293744700008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64531
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Jin-Yang,He, Bing,Qu, Wei,et al. Preparation of the albumin nanoparticle system loaded with both paclitaxel and sorafenib and its evaluation in vitro and in vivo[J]. JOURNAL OF MICROENCAPSULATION,2011,28(6):528-536.
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