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学科主题: 临床医学
题名:
alpha(1A)-adrenergic receptor mediated pressor response to phenylephrine in anesthetized rat
作者: Xu, Q; Zhu, WZ; Lu, ZZ; Zhang, YY; Han, QD
关键词: alpha(1)-adrenergic receptor ; blood pressure ; antagonist ; spontaneous hypertensive rats
刊名: SCIENCE IN CHINA SERIES C-LIFE SCIENCES
发表日期: 2004-02-01
DOI: 10.1360/02yc0051
卷: 47, 期:1, 页:59-65
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
关键词[WOS]: SPONTANEOUSLY HYPERTENSIVE-RATS ; BLOOD-PRESSURE ; ALPHA(1)-ADRENOCEPTOR SUBTYPES ; FUNCTIONAL EXPRESSION ; PRAZOSIN ANALOG ; VASCULAR BED ; AORTA ; ALPHA(1D)-ADRENOCEPTORS ; ALPHA-1A-ADRENOCEPTORS ; ALPHA-1-ADRENOCEPTORS
英文摘要:

To determine which subtype of alpha(1)-adrenergic receptors plays a role in the regulation of blood pressure, with alpha(1A)-adrenergic receptor-mediated vasoconstriction in perfused hindlimb as a control, we compared the inhibitory effects of various alpha(1)-adrenergic receptor selective antagonists on the vasopressure responses to phenylephrine between the mean arterial pressure and hindlimb perfusion pressure in anesthetized rats. In Normotensive Wistar rats, the results showed that the inhibitory effects (dose ratios of ED50, Dr) of alpha(1)-adrenoceptor selective antagonist (prazosin, Dr 13.5 +/- 3.6 vs. 15.1 +/- 4.3, n = 11), alpha(1A)-adrenoceptor selective antagonist (5-methyl-urapidil, Dr 2.4 +/- 0.9 vs. 3.7 +/- 2.3, n = 12; RS-17053, Dr 3.2 +/- 1.6 vs. 4.4 +/- 3.3, n =12) and alpha(1D)- adrenoceptor selective antagonist (BMY7378, Dr 1.9 +/- 0.9.vs. 2.2 +/- 0.8, n=8) on phenylephrine-induced increases of perfusion pressure in the autoperfused femoral beds were the same as that in the mean arterial blood pressure in normotensive Wistar rats. The inhibitory effects of antagonists (RS-17053, Dr 3.4 +/- 0.6 vs. 4.3 +/- 0.9, n = 5; BMY7378, Dr 1.7 +/- 0.5 vs. 1.7 +/- 0.5, n = 8) in spontaneous hypertensive rats were similar with the Wistar rats. These results suggest that the mean arterial pressure induced by phenylephrine was mainly mediated by alpha(1A)-adrenergic receptor in both the anesthetized Wistar rats and spontaneous hypertensive rats.

语种: 英语
WOS记录号: WOS:000188951300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64533
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Inst Vasc Med, Key Lab Mol Cardiol,Minist Educ, Beijing 100083, Peoples R China

Recommended Citation:
Xu, Q,Zhu, WZ,Lu, ZZ,et al. alpha(1A)-adrenergic receptor mediated pressor response to phenylephrine in anesthetized rat[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2004,47(1):59-65.
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