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学科主题临床医学
alpha(1A)-adrenergic receptor mediated pressor response to phenylephrine in anesthetized rat
Xu, Q; Zhu, WZ; Lu, ZZ; Zhang, YY; Han, QD
关键词alpha(1)-adrenergic receptor blood pressure antagonist spontaneous hypertensive rats
刊名SCIENCE IN CHINA SERIES C-LIFE SCIENCES
2004-02-01
DOI10.1360/02yc0051
47期:1页:59-65
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology
研究领域[WOS]Life Sciences & Biomedicine - Other Topics
关键词[WOS]SPONTANEOUSLY HYPERTENSIVE-RATS ; BLOOD-PRESSURE ; ALPHA(1)-ADRENOCEPTOR SUBTYPES ; FUNCTIONAL EXPRESSION ; PRAZOSIN ANALOG ; VASCULAR BED ; AORTA ; ALPHA(1D)-ADRENOCEPTORS ; ALPHA-1A-ADRENOCEPTORS ; ALPHA-1-ADRENOCEPTORS
英文摘要

To determine which subtype of alpha(1)-adrenergic receptors plays a role in the regulation of blood pressure, with alpha(1A)-adrenergic receptor-mediated vasoconstriction in perfused hindlimb as a control, we compared the inhibitory effects of various alpha(1)-adrenergic receptor selective antagonists on the vasopressure responses to phenylephrine between the mean arterial pressure and hindlimb perfusion pressure in anesthetized rats. In Normotensive Wistar rats, the results showed that the inhibitory effects (dose ratios of ED50, Dr) of alpha(1)-adrenoceptor selective antagonist (prazosin, Dr 13.5 +/- 3.6 vs. 15.1 +/- 4.3, n = 11), alpha(1A)-adrenoceptor selective antagonist (5-methyl-urapidil, Dr 2.4 +/- 0.9 vs. 3.7 +/- 2.3, n = 12; RS-17053, Dr 3.2 +/- 1.6 vs. 4.4 +/- 3.3, n =12) and alpha(1D)- adrenoceptor selective antagonist (BMY7378, Dr 1.9 +/- 0.9.vs. 2.2 +/- 0.8, n=8) on phenylephrine-induced increases of perfusion pressure in the autoperfused femoral beds were the same as that in the mean arterial blood pressure in normotensive Wistar rats. The inhibitory effects of antagonists (RS-17053, Dr 3.4 +/- 0.6 vs. 4.3 +/- 0.9, n = 5; BMY7378, Dr 1.7 +/- 0.5 vs. 1.7 +/- 0.5, n = 8) in spontaneous hypertensive rats were similar with the Wistar rats. These results suggest that the mean arterial pressure induced by phenylephrine was mainly mediated by alpha(1A)-adrenergic receptor in both the anesthetized Wistar rats and spontaneous hypertensive rats.

语种英语
WOS记录号WOS:000188951300009
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64533
专题北京大学第三临床医学院_心血管内科
作者单位Peking Univ, Hosp 3, Inst Vasc Med, Key Lab Mol Cardiol,Minist Educ, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Xu, Q,Zhu, WZ,Lu, ZZ,et al. alpha(1A)-adrenergic receptor mediated pressor response to phenylephrine in anesthetized rat[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2004,47(1):59-65.
APA Xu, Q,Zhu, WZ,Lu, ZZ,Zhang, YY,&Han, QD.(2004).alpha(1A)-adrenergic receptor mediated pressor response to phenylephrine in anesthetized rat.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,47(1),59-65.
MLA Xu, Q,et al."alpha(1A)-adrenergic receptor mediated pressor response to phenylephrine in anesthetized rat".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 47.1(2004):59-65.
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