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学科主题: 临床医学
题名:
HIGH-INTENSITY FOCUSED ULTRASOUND TREATMENT OF LATE-STAGE PANCREATIC BODY CARCINOMA: OPTIMAL TUMOR DEPTH FOR SAFE ABLATION
作者: Ge, Hui-Yu1; Miao, Li-Ying1; Xiong, Liu-Lin2; Yan, Fang3; Zheng, Cui-Shan1; Wang, Jin-Rui1; Jia, Jian-Wen1; Cui, Li-Gang1; Chen, Wen1
关键词: High-intensity focused ultrasound ; Ultrasound ; Computed tomography ; Depth ; Pancreatic cancer ; Carcinoma ; Ablation ; Safety profile
刊名: ULTRASOUND IN MEDICINE AND BIOLOGY
发表日期: 2014-05-01
DOI: 10.1016/j.ultrasmedbio.2013.11.020
卷: 40, 期:5, 页:947-955
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Acoustics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: CANCER ; THERAPY
英文摘要:

Objective criteria are currently not available for assessing the extent of ablation by high-intensity focused ultrasound (HIFU). A retrospective review was conducted in Chinese patients with late-stage pancreatic body carcinoma treated with 1 h/d intermittent HIFU at a single center. Clinical and procedure-related characteristics were examined in relation to tumor posterior depth. Clinically, tumor ablation was negatively correlated with posterior tumor depth, with a 1-cm increase in depth decreasing ablation by 30.7%. At a computed tomography (CT)-determined 7-cm posterior tumor depth (considered the critical value for the procedure), ablation sensitivity and specificity were 77.8% and 72.7%, respectively. Tumor ablation >30% in patients with a CT-determined posterior tumor depth <= 7 cm was 9.333 times better than that in patients with a CT-determined posterior tumor depth >7 cm. Adverse effects did not affect the efficacy of HIFU. Tumors with posterior depths <7 cm may effectively be treated with HIFU-induced ablation with minimal adverse events. (E-mail: ghyzmw@163.com or huiyugemedsci@163.com and xiongliulin@sina.com) Crown Copyright (C) 2014 Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.

语种: 英语
WOS记录号: WOS:000333753600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64538
Appears in Collections:北京大学第三临床医学院_超声诊断科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Ultrasound, Beijing 100191, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100191, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Clin Epidemiol Res Grp, Beijing, Peoples R China

Recommended Citation:
Ge, Hui-Yu,Miao, Li-Ying,Xiong, Liu-Lin,et al. HIGH-INTENSITY FOCUSED ULTRASOUND TREATMENT OF LATE-STAGE PANCREATIC BODY CARCINOMA: OPTIMAL TUMOR DEPTH FOR SAFE ABLATION[J]. ULTRASOUND IN MEDICINE AND BIOLOGY,2014,40(5):947-955.
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