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学科主题: 基础医学
题名:
The metabolic evidence of synergistic interaction between DAMGO and DPDPE on undifferentiated SH-SY5Y cells
作者: Chen, ZW; Yang, K; Wang, Y; Han, JS
关键词: DAMGO ; DPDPE ; microphysiometer ; SH-SY5Y cells ; synergy ; mu-opioid receptor ; delta-opioid receptor
刊名: NEUROREPORT
发表日期: 2001-03-26
卷: 12, 期:4, 页:845-849
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: OPIOID RECEPTORS ; MICE LACKING ; SPINAL-CORD
英文摘要:

Recent studies have demonstrated the analgesic synergy between mu- and delta -opioid receptor, but evidence obtained at the cellular level is scanty. This work was designed to find the evidence of synergy between the actions of D-Ala(2)-Mephe(4)-glyol(5) enkephalin (DAMGO) and D-Phe(2), D-Phe(5) enkephalin (DPDPE) on undifferentiated SH-SY5Y cells. Microphysiometer was used to detect the functional activity of cells by measuring the real-time extracellular acidification rate (ECAR). The results demonstrate the unequivocal synergy between DAMGO and DPDPE at least within certain ratios. In addition, combined administration of the two drugs in the synergistic ratios attenuates receptor desensitization. These data indicate that DAMGO and DPDPE have a synergistic effect at cellular level. NeuroReport 12:845-849 (C) 2001 Lippincott Williams & Wilkins.

语种: 英语
WOS记录号: WOS:000167504700043
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64544
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Chen, ZW,Yang, K,Wang, Y,et al. The metabolic evidence of synergistic interaction between DAMGO and DPDPE on undifferentiated SH-SY5Y cells[J]. NEUROREPORT,2001,12(4):845-849.
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