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学科主题基础医学
The metabolic evidence of synergistic interaction between DAMGO and DPDPE on undifferentiated SH-SY5Y cells
Chen, ZW; Yang, K; Wang, Y; Han, JS
关键词DAMGO DPDPE microphysiometer SH-SY5Y cells synergy mu-opioid receptor delta-opioid receptor
刊名NEUROREPORT
2001-03-26
12期:4页:845-849
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]OPIOID RECEPTORS ; MICE LACKING ; SPINAL-CORD
英文摘要

Recent studies have demonstrated the analgesic synergy between mu- and delta -opioid receptor, but evidence obtained at the cellular level is scanty. This work was designed to find the evidence of synergy between the actions of D-Ala(2)-Mephe(4)-glyol(5) enkephalin (DAMGO) and D-Phe(2), D-Phe(5) enkephalin (DPDPE) on undifferentiated SH-SY5Y cells. Microphysiometer was used to detect the functional activity of cells by measuring the real-time extracellular acidification rate (ECAR). The results demonstrate the unequivocal synergy between DAMGO and DPDPE at least within certain ratios. In addition, combined administration of the two drugs in the synergistic ratios attenuates receptor desensitization. These data indicate that DAMGO and DPDPE have a synergistic effect at cellular level. NeuroReport 12:845-849 (C) 2001 Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000167504700043
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64544
专题北京大学基础医学院_神经生物学系
作者单位Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
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GB/T 7714
Chen, ZW,Yang, K,Wang, Y,et al. The metabolic evidence of synergistic interaction between DAMGO and DPDPE on undifferentiated SH-SY5Y cells[J]. NEUROREPORT,2001,12(4):845-849.
APA Chen, ZW,Yang, K,Wang, Y,&Han, JS.(2001).The metabolic evidence of synergistic interaction between DAMGO and DPDPE on undifferentiated SH-SY5Y cells.NEUROREPORT,12(4),845-849.
MLA Chen, ZW,et al."The metabolic evidence of synergistic interaction between DAMGO and DPDPE on undifferentiated SH-SY5Y cells".NEUROREPORT 12.4(2001):845-849.
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