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学科主题: 临床医学
题名:
Detection of Human Papilloma Virus Type 16 E6 mRNA in Laryngeal Squamous Cell Carcinoma by In Situ Hybridization
作者: Jiang, Hai-rong2; Wang, Peng1; Li, Yong3; Ning, Tao3; Rao, Xiao-song4; Liu, Bao-guo1
关键词: Laryngeal squamous cell carcinoma ; Human papilloma virus ; In situ hybridization
刊名: CHINESE JOURNAL OF CANCER RESEARCH
发表日期: 2010-09-01
DOI: 10.1007/s11670-010-0218-1
卷: 22, 期:3, 页:218-223
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: POLYMERASE CHAIN-REACTION ; CONSENSUS PRIMERS ; CERVICAL-CANCER ; LUNG-CANCER ; HEAD ; NECK ; HPV ; PREVALENCE ; DNA ; PROTEIN
英文摘要:

Objective: Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor in Northeast China and is frequently associated with well-established risk factors like smoking and alcohol abuse. Human papilloma virus (HPV) is an epitheliotropic oncogenic virus that has been detected in a variety of head and neck tumors including LSCC. This retrospective study was to investigate the prevalence of HPV infection in patients with LSCC.

Methods: In situ hybridization was performed in 99 patients with LSCC to detect the expression of HPV-16 E6 mRNA.

Results: The positive rate of HPV16 E6 mRNA was 36.36% (36/99) in laryngeal squamous cell carcinoma (LSCC), whereas only 3 of 50 (6%) specimens of the normal laryngeal mucosa as a control group showed positive results (P < 0.05). Additionally, there was no corelation between HPV16 and age, gender, clinical stage, nodal status and tumor site (P > 0.05).

Conclusion: The results suggest that the increased prevalence of HPV infection compared to normal laryngeal mucosa and the fact that high-risk HPV types (especially type 16) were the most frequently identified do not allow the exclusion of HPV as a risk factor in laryngeal squamous cell carcinoma. However, their clinical value remains to be further investigated.

语种: 英语
WOS记录号: WOS:000288439100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64546
Appears in Collections:北京大学临床肿瘤学院_遗传学研究室_期刊论文

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作者单位: 1.Peking Univ, Beijing Canc Hosp & Inst, Dept Head & Neck Surg,Sch Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Chongqing Med Univ, Dept Clin Lab, Chongqing 630001, Peoples R China
3.Peking Univ, Dept Genet, Beijing Canc Hosp & Inst,Sch Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
4.Peking Univ, Shougang Hosp, Dept Pathol, Beijing 100144, Peoples R China

Recommended Citation:
Jiang, Hai-rong,Wang, Peng,Li, Yong,et al. Detection of Human Papilloma Virus Type 16 E6 mRNA in Laryngeal Squamous Cell Carcinoma by In Situ Hybridization[J]. CHINESE JOURNAL OF CANCER RESEARCH,2010,22(3):218-223.
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