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学科主题临床医学
Effect of spleen operation on antiviral treatment in hepatitis C virus-related cirrhotic patients
Feng, Bo; Zhang, Wei; Luo, Bi-Fen; Song, Guang-Jun; Wang, Jian; Jin, Qian; Qin, Hong; Wei, Lai
关键词Hepatitis C virus cirrhosis Interferon Ribavirin Splenectomy Partial splenic embolization
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2014-11-07
DOI10.3748/wjg.v20.i41.15387
20期:41页:15387-15397
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]PARTIAL SPLENIC EMBOLIZATION ; LAPAROSCOPIC SPLENECTOMY ; COMBINATION THERAPY ; PEGYLATED INTERFERON ; THROMBOCYTOPENIA ; INFECTION ; RIBAVIRIN ; GENOTYPE ; HYPERSPLENISM ; PEGINTERFERON
英文摘要

AIM: To investigate the impact of spleen operation (SO) on interferon-alpha (IFN-alpha)-based antiviral treatment in patients with hepatitis C virus (HCV)-related cirrhosis.

METHODS: Studies were systematically identified by searching electronic databases including MEDLINE, Cochrane Library, Elsevier, and Embase up to September 30, 2013, and relevant clinical studies were reviewed. Sustained virological response (SVR) rate and adherence to therapy were taken as the endpoints of interest.

RESULTS: A total of 603 patients from 16 studies were included in the systematic review. Of 372 patients who underwent SO followed by antiviral treatment, the total SVR rate was 39.5%. SVR was associated with HCV genotypes 2/3 (OR = 10.84; 95%CI: 5.47-21.47; P < 0.00001). IFN-alpha dose needed to be reduced in 29.4%, and IFN-alpha-based therapy was discontinued in 11.5% of patients. Analysis of controlled studies showed that SVRs were achieved in 34.1% of patients with SO and 31.1% of patients without SO. SO had no effect on the SVR rate in cirrhotic patients with genotype 1 HCV infection (OR = 1.28; 95%CI: 0.51-3.22; P = 0.60), but improved the SVR rate in patients with genotypes 2/3 infection, though the difference was not significant (OR = 0.36; 95%CI: 0.13-1.02; P = 0.05).

CONCLUSION: SO combined with IFN-alpha-based antiviral therapy may be suitable in cirrhotic patients with genotypes 2/3 HCV infection, but not in those with genotype 1 infection. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

语种英语
WOS记录号WOS:000345115100041
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64552
专题北京大学第二临床医学院_肝病科
北京大学第二临床医学院_北京大学肝病研究所
作者单位Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Feng, Bo,Zhang, Wei,Luo, Bi-Fen,et al. Effect of spleen operation on antiviral treatment in hepatitis C virus-related cirrhotic patients[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2014,20(41):15387-15397.
APA Feng, Bo.,Zhang, Wei.,Luo, Bi-Fen.,Song, Guang-Jun.,Wang, Jian.,...&Wei, Lai.(2014).Effect of spleen operation on antiviral treatment in hepatitis C virus-related cirrhotic patients.WORLD JOURNAL OF GASTROENTEROLOGY,20(41),15387-15397.
MLA Feng, Bo,et al."Effect of spleen operation on antiviral treatment in hepatitis C virus-related cirrhotic patients".WORLD JOURNAL OF GASTROENTEROLOGY 20.41(2014):15387-15397.
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