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学科主题: 精神卫生
题名:
The monoamine oxidase B gene exhibits significant association to ADHD
作者: Li, Jun1; Wang, Yufeng1; Hu, Songnian2; Zhou, Rulun1; Yu, Xiaomin2; Wang, Bing1; Guan, Lili1; Yang, Li1; Zhang, Feng2; Faraone, Stephen V.3,4,5
关键词: gene ; ADHD ; X chromosome ; sequence ; monoamine oxidase B
刊名: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
发表日期: 2008-04-05
DOI: 10.1002/ajmg.b.30606
卷: 147B, 期:3, 页:370-374
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Psychiatry
研究领域[WOS]: Genetics & Heredity ; Psychiatry
关键词[WOS]: DEFICIT HYPERACTIVITY DISORDER ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; PLATELET MAO ; PREFERENTIAL TRANSMISSION ; DXS7 LOCUS ; LINKAGE ; POLYMORPHISMS ; IMPULSIVITY ; POPULATION ; CHILDREN
英文摘要:

Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition with strong genetic basis. Recent work in China indicated that ADHD may be linked to Xp1-2 in the Han Chinese population. The gene encoding monoamine oxidase B (MAOB), the main enzyme degrading dopamine in the human brain, is located in this region. The current study sequenced the exons and the 5′ and 3′ flanking regions of the MAOB gene and found four common variants including 2276C>T and 2327C>T in exon 15, rs1799836 in intron 13 and rs1040399 in 3′-UTR. We assessed the association of these variants with ADHD in 548 trios collected from 468 males and 80 females probands. TDT analysis showed that alleles of each polymorphism were preferentially transmitted to probands (rs1799836, P = 3.28E-15; rs1040399, P = 1.87E-6; 2276T>C or 2327T>C, P = 2.20E-6) and haplotype-based TDT analyses also found distorted transmission. In conclusion, this study provides the strongest evidence for the involvement of MAOB gene in the etiology of ADHD to date, at least in Han Chinese population. (C) 2007 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000254569400015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64553
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Sixth Hosp, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Beijing Airport Ind Zone B6, Beijing Genom Inst, Beijing, Peoples R China
3.SUNY Upstate Med Univ, Genet Res Program, Syracuse, NY USA
4.SUNY Upstate Med Univ, Dept Psychiat & Neurosci, Syracuse, NY USA
5.SUNY Upstate Med Univ, Dept Physiol, Syracuse, NY USA

Recommended Citation:
Li, Jun,Wang, Yufeng,Hu, Songnian,et al. The monoamine oxidase B gene exhibits significant association to ADHD[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2008,147B(3):370-374.
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