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The monoamine oxidase B gene exhibits significant association to ADHD
Li, Jun1; Wang, Yufeng1; Hu, Songnian2; Zhou, Rulun1; Yu, Xiaomin2; Wang, Bing1; Guan, Lili1; Yang, Li1; Zhang, Feng2; Faraone, Stephen V.3,4,5
关键词gene ADHD X chromosome sequence monoamine oxidase B
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2008-04-05
DOI10.1002/ajmg.b.30606
147B期:3页:370-374
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]DEFICIT HYPERACTIVITY DISORDER ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; PLATELET MAO ; PREFERENTIAL TRANSMISSION ; DXS7 LOCUS ; LINKAGE ; POLYMORPHISMS ; IMPULSIVITY ; POPULATION ; CHILDREN
英文摘要

Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition with strong genetic basis. Recent work in China indicated that ADHD may be linked to Xp1-2 in the Han Chinese population. The gene encoding monoamine oxidase B (MAOB), the main enzyme degrading dopamine in the human brain, is located in this region. The current study sequenced the exons and the 5′ and 3′ flanking regions of the MAOB gene and found four common variants including 2276C>T and 2327C>T in exon 15, rs1799836 in intron 13 and rs1040399 in 3′-UTR. We assessed the association of these variants with ADHD in 548 trios collected from 468 males and 80 females probands. TDT analysis showed that alleles of each polymorphism were preferentially transmitted to probands (rs1799836, P = 3.28E-15; rs1040399, P = 1.87E-6; 2276T>C or 2327T>C, P = 2.20E-6) and haplotype-based TDT analyses also found distorted transmission. In conclusion, this study provides the strongest evidence for the involvement of MAOB gene in the etiology of ADHD to date, at least in Han Chinese population. (C) 2007 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000254569400015
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64553
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Sixth Hosp, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Beijing Airport Ind Zone B6, Beijing Genom Inst, Beijing, Peoples R China
3.SUNY Upstate Med Univ, Genet Res Program, Syracuse, NY USA
4.SUNY Upstate Med Univ, Dept Psychiat & Neurosci, Syracuse, NY USA
5.SUNY Upstate Med Univ, Dept Physiol, Syracuse, NY USA
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Li, Jun,Wang, Yufeng,Hu, Songnian,et al. The monoamine oxidase B gene exhibits significant association to ADHD[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2008,147B(3):370-374.
APA Li, Jun.,Wang, Yufeng.,Hu, Songnian.,Zhou, Rulun.,Yu, Xiaomin.,...&Faraone, Stephen V..(2008).The monoamine oxidase B gene exhibits significant association to ADHD.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,147B(3),370-374.
MLA Li, Jun,et al."The monoamine oxidase B gene exhibits significant association to ADHD".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 147B.3(2008):370-374.
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