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学科主题: 临床医学
题名:
Plasma miR-126 Is a Potential Biomarker for Early Prediction of Type 2 Diabetes Mellitus in Susceptible Individuals
作者: Zhang, Tao1; Lv, Chunfang1; Li, Liling1; Chen, Sihan2; Liu, Shenglin3; Wang, Changyi2; Su, Bing3,4,5,6,7
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2013
DOI: 10.1155/2013/761617
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: CIRCULATING MICRORNAS ; CARDIOVASCULAR-DISEASE ; PREVALENCE ; DIAGNOSIS ; PROGNOSIS
英文摘要:

Type 2 diabetes mellitus (T2DM) is a major public health problem in China. Diagnostic markers are urgently needed to identify individuals at risk of developing T2DM and encourage them to adapt to a healthier life style. Circulating miRNAs present important sources of noninvasive biomarkers of various diseases. Recently, a novel plasma microRNA signature was identified in T2DM. Here, we evaluated the T2DM-related miRNA signature in plasma of three study groups: normal (fasting glucose (FG), 4.8-5.2 mmol/L), T2DM-susceptible (FG, 6.1-6.9 mmol/L), and T2DM individuals (FG, >= 7.0 mmol/L) and tested the feasibility of using circulating miRNAs to identify individuals at risk of developing T2DM. Among the 5 miRNAs included in the signature, miR-29b and miR-28-3p are not detectable. miR-15a and miR-223 have comparable expression levels among three groups. Notably, miR-126 is the only miRNA that showed significantly reduced expression in susceptible individuals and T2DM patients compared to normal individuals, suggesting that miR-126 in circulation may serve as a potential biomarker for early identification of susceptible individuals to T2DM.

语种: 英语
所属项目编号: 201203231
项目资助者: Shenzhen Science and Technology Project
WOS记录号: WOS:000329671200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64558
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Shenzhen Nanshan Ctr Chron Dis Control, Dept Lab Med, Shenzhen 518054, Guangdong, Peoples R China
2.Shenzhen Nanshan Ctr Chron Dis Control, Dept Control & Prevent Chron Noncommun Dis, Shenzhen 518054, Guangdong, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
4.Roswell Pk Canc Inst, Dept Canc Genet, Buffalo, NY 14263 USA
5.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 518036, Guangdong, Peoples R China
6.Peking Univ, Shenzhen Hosp, Shenzhen Key Discipline Dermatol, Shenzhen 518036, Guangdong, Peoples R China
7.SUNY Buffalo, Dept Social & Prevent Med, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14214 USA

Recommended Citation:
Zhang, Tao,Lv, Chunfang,Li, Liling,et al. Plasma miR-126 Is a Potential Biomarker for Early Prediction of Type 2 Diabetes Mellitus in Susceptible Individuals[J]. BIOMED RESEARCH INTERNATIONAL,2013.
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