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Plasma miR-126 Is a Potential Biomarker for Early Prediction of Type 2 Diabetes Mellitus in Susceptible Individuals
Zhang, Tao1; Lv, Chunfang1; Li, Liling1; Chen, Sihan2; Liu, Shenglin3; Wang, Changyi2; Su, Bing3,4,5,6,7
刊名BIOMED RESEARCH INTERNATIONAL
2013
DOI10.1155/2013/761617
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]CIRCULATING MICRORNAS ; CARDIOVASCULAR-DISEASE ; PREVALENCE ; DIAGNOSIS ; PROGNOSIS
英文摘要

Type 2 diabetes mellitus (T2DM) is a major public health problem in China. Diagnostic markers are urgently needed to identify individuals at risk of developing T2DM and encourage them to adapt to a healthier life style. Circulating miRNAs present important sources of noninvasive biomarkers of various diseases. Recently, a novel plasma microRNA signature was identified in T2DM. Here, we evaluated the T2DM-related miRNA signature in plasma of three study groups: normal (fasting glucose (FG), 4.8-5.2 mmol/L), T2DM-susceptible (FG, 6.1-6.9 mmol/L), and T2DM individuals (FG, >= 7.0 mmol/L) and tested the feasibility of using circulating miRNAs to identify individuals at risk of developing T2DM. Among the 5 miRNAs included in the signature, miR-29b and miR-28-3p are not detectable. miR-15a and miR-223 have comparable expression levels among three groups. Notably, miR-126 is the only miRNA that showed significantly reduced expression in susceptible individuals and T2DM patients compared to normal individuals, suggesting that miR-126 in circulation may serve as a potential biomarker for early identification of susceptible individuals to T2DM.

语种英语
WOS记录号WOS:000329671200001
项目编号201203231
资助机构Shenzhen Science and Technology Project
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64558
专题北京大学深圳医院
作者单位1.Shenzhen Nanshan Ctr Chron Dis Control, Dept Lab Med, Shenzhen 518054, Guangdong, Peoples R China
2.Shenzhen Nanshan Ctr Chron Dis Control, Dept Control & Prevent Chron Noncommun Dis, Shenzhen 518054, Guangdong, Peoples R China
3.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
4.Roswell Pk Canc Inst, Dept Canc Genet, Buffalo, NY 14263 USA
5.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 518036, Guangdong, Peoples R China
6.Peking Univ, Shenzhen Hosp, Shenzhen Key Discipline Dermatol, Shenzhen 518036, Guangdong, Peoples R China
7.SUNY Buffalo, Dept Social & Prevent Med, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14214 USA
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GB/T 7714
Zhang, Tao,Lv, Chunfang,Li, Liling,et al. Plasma miR-126 Is a Potential Biomarker for Early Prediction of Type 2 Diabetes Mellitus in Susceptible Individuals[J]. BIOMED RESEARCH INTERNATIONAL,2013.
APA Zhang, Tao.,Lv, Chunfang.,Li, Liling.,Chen, Sihan.,Liu, Shenglin.,...&Su, Bing.(2013).Plasma miR-126 Is a Potential Biomarker for Early Prediction of Type 2 Diabetes Mellitus in Susceptible Individuals.BIOMED RESEARCH INTERNATIONAL.
MLA Zhang, Tao,et al."Plasma miR-126 Is a Potential Biomarker for Early Prediction of Type 2 Diabetes Mellitus in Susceptible Individuals".BIOMED RESEARCH INTERNATIONAL (2013).
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