IR@PKUHSC  > 北京大学第一临床医学院  > 泌尿外科
学科主题临床医学
Prevalence and Risk Factors of Prostate Cancer in Chinese Men with PSA 4-10 ng/mL Who Underwent TRUS-Guided Prostate Biopsy: The Utilization of PAMD Score
Fang, Dong1; Ren, Da1; Zhao, Chenglin2; Li, Xuesong1; Yu, Wei1; Wang, Rui2; Wang, Huihui2; Xi, Chenguang1; He, Qun1; Wang, Xiaoying2; Xin, Zhongcheng1; Zhou, Liqun1
刊名BIOMED RESEARCH INTERNATIONAL
2015
DOI10.1155/2015/596797
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]PROSPECTIVE MULTICENTER ; GRAY-SCALE ; ANTIGEN ; NOMOGRAM ; VALIDATION ; GUIDELINES ; MORTALITY ; DIAGNOSIS ; TRIAL ; COLOR
英文摘要

Purpose. To elucidate the characteristics and risk factors for positive biopsy outcomes in Chinese patients with prostate specific antigen (PSA) 4-10 ng/mL and develop a risk-stratification score model. Methods. The data of 345 patients who underwent transrectal ultrasound-guided prostate biopsy between 2011 and 2013 was retrospectively analyzed. Digital rectal examination (DRE), prostate volume (PV), magnetic resonance imaging (MRI), and smoking status were also collected. Positive biopsy outcomes were defined as prostate cancer (PCa) and high grade PCa (HGPCa, Gleason Score >= 7). Results. The median PSA was 7.15 (IQR 5.91-8.45) ng/mL. Overall 138 patients (40.0%) were shown to have PCa, including 100 patients (29.0%) with HGPCa. Smaller PV, elder age, MRI results, and positive DRE were proved to be predictive factors for positive biopsy outcomes in both univariate and multivariate analysis. We developed a "PAMD" score which combined the four factors to categorize patients into three risk groups, and the model performed good predictive sensitivity and specificity. Conclusion. The prevalence of prostate cancer in Chinese patients with PSA 4-10 ng/mL was 40%, including 29% patients with high grade disease. DRE, age, MRI, and PV were predictive factors for positive biopsy outcomes, and the PAMD score model could be utilized for risk-stratification and decision-making.

语种英语
WOS记录号WOS:000364069300001
项目编号TG-2014-13
资助机构Beijing Municipal Commission of Health and Family Planning ; Science and technology achievements
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64560
专题北京大学第一临床医学院_泌尿外科
北京大学第一临床医学院_医学影像科
北京大学第二临床医学院_重症医学科
作者单位1.Peking Univ, Natl Urol Canc Ctr, Inst Urol, Hosp 1,Dept Urol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Fang, Dong,Ren, Da,Zhao, Chenglin,et al. Prevalence and Risk Factors of Prostate Cancer in Chinese Men with PSA 4-10 ng/mL Who Underwent TRUS-Guided Prostate Biopsy: The Utilization of PAMD Score[J]. BIOMED RESEARCH INTERNATIONAL,2015.
APA Fang, Dong.,Ren, Da.,Zhao, Chenglin.,Li, Xuesong.,Yu, Wei.,...&Zhou, Liqun.(2015).Prevalence and Risk Factors of Prostate Cancer in Chinese Men with PSA 4-10 ng/mL Who Underwent TRUS-Guided Prostate Biopsy: The Utilization of PAMD Score.BIOMED RESEARCH INTERNATIONAL.
MLA Fang, Dong,et al."Prevalence and Risk Factors of Prostate Cancer in Chinese Men with PSA 4-10 ng/mL Who Underwent TRUS-Guided Prostate Biopsy: The Utilization of PAMD Score".BIOMED RESEARCH INTERNATIONAL (2015).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fang, Dong]的文章
[Ren, Da]的文章
[Zhao, Chenglin]的文章
百度学术
百度学术中相似的文章
[Fang, Dong]的文章
[Ren, Da]的文章
[Zhao, Chenglin]的文章
必应学术
必应学术中相似的文章
[Fang, Dong]的文章
[Ren, Da]的文章
[Zhao, Chenglin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。