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Association of chemical constituents and pollution sources of ambient fine particulate air pollution and biomarkers of oxidative stress associated with atherosclerosis: A panel study among young adults in Beijing, China
Wu, Shaowei1; Yang, Di1; Wei, Hongying1; Wang, Bin2; Huang, Jing1; Li, Hongyu1; Shima, Masayuki3; Deng, Furong1; Guo, Xinbiao1
关键词Air pollution Atherosclerosis Metal Oxidative stress Oxidized low-density lipoprotein Particulate matter
刊名CHEMOSPHERE
2015-09-01
DOI10.1016/j.chemosphere.2015.04.096
135页:347-353
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences
研究领域[WOS]Environmental Sciences & Ecology
关键词[WOS]LOW-DENSITY-LIPOPROTEIN ; NATURAL RELOCATION HVNR ; IN-VITRO ; HOSPITAL ADMISSIONS ; TRANSITION-METALS ; TAXI DRIVERS ; HONG-KONG ; EXPOSURE ; MATTER ; HEALTHY
英文摘要

Ambient particulate air pollution has been associated with increased oxidative stress and atherosclerosis, but the chemical constituents and pollution sources behind the association are unclear. We investigated the associations of various chemical constituents and pollution sources of ambient fine particles (PM2.5) with biomarkers of oxidative stress in a panel of 40 healthy university students. Study participants underwent repeated blood collections for 12 times before and after relocating from a suburban campus to an urban campus with high air pollution levels in Beijing, China. Air pollution data were obtained from central air-monitoring stations, and plasma levels of oxidized low-density lipoprotein (Ox-LDL) and soluble CD36 (sCD36) were determined in the laboratory (n = 464). Linear mixed-effects models were used to estimate the changes in biomarkers in association with exposure variables. PM2.5 iron and nickel were positively associated with Ox-LDL (p < 0.05). For each interquartile range increase in iron (1-day, 0.51 mu g/m(3)) and nickel (2-day, 2.5 ng/m(3)), there were a 1.9% [95% confidence interval (CI: 0.2%, 3.7%] increase and a 1.8% (95% CI: 0.2%, 3.4%) increase in Ox-LDL, respectively. We also found that each interquartile range increase in calcium (1-day, 0.7 mu g/m(3)) was associated with a 4.8% (95% CI: 0.7%, 9.1%) increase in sCD36. Among the pollution sources, PM2.5 from traffic emissions and coal combustion were suggestively and positively associated with Ox-LDL. Our findings suggest that a subset of metals in airborne particles may be the major air pollution components that contribute to the increased oxidative stress associated with atherosclerosis. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000356740900045
项目编号20131000109 ; 81072267 ; 41401583 ; 2006BA119B06
资助机构special grant for Excellent Doctoral Dissertation from Beijing Municipal Commission of Education ; National Natural Science Foundation of China ; National Key Technologies R&amp ; D Program of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64566
专题北京大学公共卫生学院
作者单位1.Hyogo Coll Med, Dept Publ Hlth, Nishinomiya, Hyogo, Japan
2.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
3.Peking Univ, Sch Publ Hlth, Inst Reprod & Child Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wu, Shaowei,Yang, Di,Wei, Hongying,et al. Association of chemical constituents and pollution sources of ambient fine particulate air pollution and biomarkers of oxidative stress associated with atherosclerosis: A panel study among young adults in Beijing, China[J]. CHEMOSPHERE,2015,135:347-353.
APA Wu, Shaowei.,Yang, Di.,Wei, Hongying.,Wang, Bin.,Huang, Jing.,...&Guo, Xinbiao.(2015).Association of chemical constituents and pollution sources of ambient fine particulate air pollution and biomarkers of oxidative stress associated with atherosclerosis: A panel study among young adults in Beijing, China.CHEMOSPHERE,135,347-353.
MLA Wu, Shaowei,et al."Association of chemical constituents and pollution sources of ambient fine particulate air pollution and biomarkers of oxidative stress associated with atherosclerosis: A panel study among young adults in Beijing, China".CHEMOSPHERE 135(2015):347-353.
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