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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Host APCs Augment In Vivo Expansion of Donor Natural Regulatory T Cells via B7H1/B7.1 in Allogeneic Recipients
作者: Yi, Tangsheng1,2,3; Li, Xiaofan2,3,4; Yao, Sheng5; Wang, Lin1; Chen, Yuhong2,3,6; Zhao, Dongchang2,3; Johnston, Heather F.1,2,3; Young, James S.1,2,3; Liu, Hongjun2,3; Todorov, Ivan3; Forman, Stephen J.2,3; Chen, Lieping5; Zeng, Defu1,2,3
刊名: JOURNAL OF IMMUNOLOGY
发表日期: 2011-03-01
DOI: 10.4049/jimmunol.1002939
卷: 186, 期:5, 页:2739-2749
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; BONE-MARROW-TRANSPLANTATION ; ANTIGEN-PRESENTING CELLS ; IFN-GAMMA ; RETINOIC-ACID ; TGF-BETA ; DEPENDENT MECHANISM ; DISEASE LETHALITY ; B-CELLS ; IMMUNITY
英文摘要:

Foxp3(+) regulatory T (Treg) cells include thymic-derived natural Treg and conventional T-derived adaptive Treg cells. Both are proposed to play important roles in downregulating inflammatory immune responses. However, the mechanisms of Treg expansion in inflammatory environments remain unclear. In this study, we report that, in an autoimmune-like graft-versus-host disease model of DBA/2 (H-2(d)) donor to BALB/c (H-2(d)) recipients, donor Treg cells in the recipients predominantly originated from expansion of natural Treg cells and few originated from adaptive Treg cells. In vivo neutralization of IFN-gamma resulted in a marked reduction of donor natural Treg expansion and exacerbation of graft-versus-host disease, which was associated with downregulation of host APC expression of B7H1. Furthermore, host APC expression of B7H1 was shown to augment donor Treg survival and expansion. Finally, donor Treg interactions with host APCs via B7.1/B7H1 but not PD-1/B7H1 were demonstrated to be critical in augmenting donor Treg survival and expansion. These studies have revealed a new immune regulation loop consisting of T cell-derived IFN-gamma, B7H1 expression by APCs, and B7.1 expression by Treg cells. The Journal of Immunology, 2011, 186: 2739-2749.

语种: 英语
所属项目编号: R01AI066008
项目资助者: National Institutes of Health
WOS记录号: WOS:000287356900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64568
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.City Hope Natl Med Ctr, Irell & Manella Grad Sch Biol Sci, Beckman Res Inst, Duarte, CA 91010 USA
2.City Hope Natl Med Ctr, Beckman Res Inst, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA 91010 USA
3.City Hope Natl Med Ctr, Beckman Res Inst, Dept Diabet Res, Duarte, CA 91010 USA
4.Fujian Med Univ Union Hosp, Fujian Inst Hematol, Dept Hematol, Fuzhou, Peoples R China
5.Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA
6.Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, Beijing 100871, Peoples R China

Recommended Citation:
Yi, Tangsheng,Li, Xiaofan,Yao, Sheng,et al. Host APCs Augment In Vivo Expansion of Donor Natural Regulatory T Cells via B7H1/B7.1 in Allogeneic Recipients[J]. JOURNAL OF IMMUNOLOGY,2011,186(5):2739-2749.
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