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Host APCs Augment In Vivo Expansion of Donor Natural Regulatory T Cells via B7H1/B7.1 in Allogeneic Recipients
Yi, Tangsheng1,2,3; Li, Xiaofan2,3,4; Yao, Sheng5; Wang, Lin1; Chen, Yuhong2,3,6; Zhao, Dongchang2,3; Johnston, Heather F.1,2,3; Young, James S.1,2,3; Liu, Hongjun2,3; Todorov, Ivan3; Forman, Stephen J.2,3; Chen, Lieping5; Zeng, Defu1,2,3
刊名JOURNAL OF IMMUNOLOGY
2011-03-01
DOI10.4049/jimmunol.1002939
186期:5页:2739-2749
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
资助者National Institutes of Health ; National Institutes of Health
研究领域[WOS]Immunology
关键词[WOS]EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; BONE-MARROW-TRANSPLANTATION ; ANTIGEN-PRESENTING CELLS ; IFN-GAMMA ; RETINOIC-ACID ; TGF-BETA ; DEPENDENT MECHANISM ; DISEASE LETHALITY ; B-CELLS ; IMMUNITY
英文摘要

Foxp3(+) regulatory T (Treg) cells include thymic-derived natural Treg and conventional T-derived adaptive Treg cells. Both are proposed to play important roles in downregulating inflammatory immune responses. However, the mechanisms of Treg expansion in inflammatory environments remain unclear. In this study, we report that, in an autoimmune-like graft-versus-host disease model of DBA/2 (H-2(d)) donor to BALB/c (H-2(d)) recipients, donor Treg cells in the recipients predominantly originated from expansion of natural Treg cells and few originated from adaptive Treg cells. In vivo neutralization of IFN-gamma resulted in a marked reduction of donor natural Treg expansion and exacerbation of graft-versus-host disease, which was associated with downregulation of host APC expression of B7H1. Furthermore, host APC expression of B7H1 was shown to augment donor Treg survival and expansion. Finally, donor Treg interactions with host APCs via B7.1/B7H1 but not PD-1/B7H1 were demonstrated to be critical in augmenting donor Treg survival and expansion. These studies have revealed a new immune regulation loop consisting of T cell-derived IFN-gamma, B7H1 expression by APCs, and B7.1 expression by Treg cells. The Journal of Immunology, 2011, 186: 2739-2749.

语种英语
所属项目编号R01AI066008
资助者National Institutes of Health ; National Institutes of Health
WOS记录号WOS:000287356900009
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64568
专题北京大学第二临床医学院_血液科
作者单位1.City Hope Natl Med Ctr, Irell & Manella Grad Sch Biol Sci, Beckman Res Inst, Duarte, CA 91010 USA
2.City Hope Natl Med Ctr, Beckman Res Inst, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA 91010 USA
3.City Hope Natl Med Ctr, Beckman Res Inst, Dept Diabet Res, Duarte, CA 91010 USA
4.Fujian Med Univ Union Hosp, Fujian Inst Hematol, Dept Hematol, Fuzhou, Peoples R China
5.Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA
6.Peking Univ, Peking Univ Peoples Hosp, Inst Hematol, Beijing 100871, Peoples R China
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Yi, Tangsheng,Li, Xiaofan,Yao, Sheng,et al. Host APCs Augment In Vivo Expansion of Donor Natural Regulatory T Cells via B7H1/B7.1 in Allogeneic Recipients[J]. JOURNAL OF IMMUNOLOGY,2011,186(5):2739-2749.
APA Yi, Tangsheng.,Li, Xiaofan.,Yao, Sheng.,Wang, Lin.,Chen, Yuhong.,...&Zeng, Defu.(2011).Host APCs Augment In Vivo Expansion of Donor Natural Regulatory T Cells via B7H1/B7.1 in Allogeneic Recipients.JOURNAL OF IMMUNOLOGY,186(5),2739-2749.
MLA Yi, Tangsheng,et al."Host APCs Augment In Vivo Expansion of Donor Natural Regulatory T Cells via B7H1/B7.1 in Allogeneic Recipients".JOURNAL OF IMMUNOLOGY 186.5(2011):2739-2749.
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