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学科主题: 药学
题名:
New cytotoxic bufadienolides from the biotransformation of resibufogenin by Mucor polymorphosporus
作者: Ye, M; Han, J; An, DG; Tu, GZ; Guo, D
关键词: biotransformation ; bufadienolide ; cytotoxicity ; Mucor polymorphosporus ; resibufogenin
刊名: TETRAHEDRON
发表日期: 2005-09-12
DOI: 10.1016/j.tet.2005.07.012
卷: 61, 期:37, 页:8947-8955
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: HUMAN LEUKEMIA-CELLS ; MICROBIAL HYDROXYLATION ; LIQUID-CHROMATOGRAPHY ; CATHARANTHUS-ROSEUS ; NATURAL-PRODUCTS ; PLUMBEUS ; BUFALIN ; CINOBUFAGIN ; DITERPENES ; 12-BETA-HYDROXYLATION
英文摘要:

Resibufogenin is a cytotoxic steroid isolated from the Chinese drug ChanSu. The biotransformation of resibufogenin by Mucor olymorphosporus afforded 22 products, and 15 of them were new. The transformation reactions involved hydroxylations at C- 1 beta, C-5, C-7 alpha, C-7 beta, C- 12 alpha, C- 12 beta and C- 16 alpha, as well as epimerization or dehydrogenation of 3-OH. Hydroxylations at C- 12 alpha, C- 12 beta and C- 16 alpha were the major reactions, each giving products in > 5% yields, whereas the other products were obtained in fairly low yields. Some of the products showed decreased but still potent cytotoxicities. This investigation provided a useful approach to prepare new bufadienolides and most of them were difficult to obtain by chemical means. (c) 2005 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000231485200019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64575
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Inst Microchem, Beijing 100091, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Ye, M,Han, J,An, DG,et al. New cytotoxic bufadienolides from the biotransformation of resibufogenin by Mucor polymorphosporus[J]. TETRAHEDRON,2005,61(37):8947-8955.
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