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New cytotoxic bufadienolides from the biotransformation of resibufogenin by Mucor polymorphosporus
Ye, M; Han, J; An, DG; Tu, GZ; Guo, D
关键词biotransformation bufadienolide cytotoxicity Mucor polymorphosporus resibufogenin
刊名TETRAHEDRON
2005-09-12
DOI10.1016/j.tet.2005.07.012
61期:37页:8947-8955
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]HUMAN LEUKEMIA-CELLS ; MICROBIAL HYDROXYLATION ; LIQUID-CHROMATOGRAPHY ; CATHARANTHUS-ROSEUS ; NATURAL-PRODUCTS ; PLUMBEUS ; BUFALIN ; CINOBUFAGIN ; DITERPENES ; 12-BETA-HYDROXYLATION
英文摘要

Resibufogenin is a cytotoxic steroid isolated from the Chinese drug ChanSu. The biotransformation of resibufogenin by Mucor olymorphosporus afforded 22 products, and 15 of them were new. The transformation reactions involved hydroxylations at C- 1 beta, C-5, C-7 alpha, C-7 beta, C- 12 alpha, C- 12 beta and C- 16 alpha, as well as epimerization or dehydrogenation of 3-OH. Hydroxylations at C- 12 alpha, C- 12 beta and C- 16 alpha were the major reactions, each giving products in > 5% yields, whereas the other products were obtained in fairly low yields. Some of the products showed decreased but still potent cytotoxicities. This investigation provided a useful approach to prepare new bufadienolides and most of them were difficult to obtain by chemical means. (c) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000231485200019
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64575
专题北京大学药学院
作者单位1.Beijing Inst Microchem, Beijing 100091, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Ye, M,Han, J,An, DG,et al. New cytotoxic bufadienolides from the biotransformation of resibufogenin by Mucor polymorphosporus[J]. TETRAHEDRON,2005,61(37):8947-8955.
APA Ye, M,Han, J,An, DG,Tu, GZ,&Guo, D.(2005).New cytotoxic bufadienolides from the biotransformation of resibufogenin by Mucor polymorphosporus.TETRAHEDRON,61(37),8947-8955.
MLA Ye, M,et al."New cytotoxic bufadienolides from the biotransformation of resibufogenin by Mucor polymorphosporus".TETRAHEDRON 61.37(2005):8947-8955.
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