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学科主题: 临床医学
题名:
Protective effect of ganoderan on renal damage in rats with chronic glomerulonephritis
作者: Zhong, Wei-De1,2; He, Hui-Chan1; Ou, Ru-Biao1; Bi, Xue-Cheng2; Dai, Qi-Shan1; Han, Zhao-Dong1; Liang, Yu-Xiang1; Ye, Yong-Kan1; Qin, Wei-Jun3; Li, Ze4; Zeng, Guo-Hua4; Zhu, Gang5
刊名: CLINICAL AND INVESTIGATIVE MEDICINE
发表日期: 2008
卷: 31, 期:4, 页:E212-E217
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: LUCIDUM ; CELLS ; INHIBITION ; TSUGAE ; MICE
英文摘要:

Purpose: To investigate the protective effect of ganoderan on renal damage in rat models with chronic glomerulonephritis induced by adriamycin.

Methods: 48 healthy Sprague-Dawley rats were randomly divided into three groups: control, nephritic model and ganoderan treatment groups. Changes of the following indices in the three groups were observed 6 weeks after treatment: 24-hour urine protein, albumen, serum creatinine, cholesterol. Histopathological observations of the renal cortex were made by light and electron microscopy.

Results: Compared with controls, levels of 24-hour urine protein ( 9.60 +/- 0.57mg/ d vs. 82.50 +/- 3.18mg/ d), serum creatinine (35.25 +/- 2.63 mu mol/ L vs. 44.75 +/- 8.06 mu mol/ L) and cholesterol (1.15 +/- 0.10mmol/ L vs. 4.02 +/- 0.25mmol/ L) of rats in the nephritic model group were increased (P < 0.05), and the concentration of albumen was decreased (35.98 +/- 1.34g/ L vs. 19.05 +/- 0.62g/ L, P < 0.05). Ganoderan administration decreased 24-hour urine protein (82.50 +/- 3.18mg/ d vs. 45.01 +/- 3.94mg/ d, P < 0.05). Following ganoderan, the pathological changes in kidney tissue were improved compared with those in the nephritic model group.

Conclusion: Ganoderan exerts protective effects in rats with chronic glomerulonephritis induced by ADR. Ganoderan reduced 24-hour urine protein, serum creatinine, cholesterol, improving renal function and reducing the severity of renal injury.

语种: 英语
WOS记录号: WOS:000258025400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64576
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Beijing Hosp Minist Publ Hlth, Beijing, Peoples R China
2.Guangzhou Med Coll, Guangzhou Municipal Peoples Hosp 1, Guangzhou 510180, Guangdong, Peoples R China
3.Nanfang Med Univ, Guangzhou 510180, Guangdong, Peoples R China
4.Fourth Mil Med Univ, XiJing Hosp, Xian 710032, Peoples R China
5.Peking Univ, First Hosp, Dept Urol, Beijing 100034, Peoples R China

Recommended Citation:
Zhong, Wei-De,He, Hui-Chan,Ou, Ru-Biao,et al. Protective effect of ganoderan on renal damage in rats with chronic glomerulonephritis[J]. CLINICAL AND INVESTIGATIVE MEDICINE,2008,31(4):E212-E217.
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