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IR@PKUHSC  > 北京大学临床肿瘤学院  > 肝胆胰外科  > 期刊论文
学科主题: 临床医学
题名:
A scoring system for prediction of early recurrence after liver resection for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma
作者: Qian Honggang; Wei Meng; Qiu Hui; Wu Jianhui; Liu Bonan; Lyu Ang; Liu Qiao; Li Chengpeng; Leng Jiahua; Zhang Ji; Hao Chunyi
关键词: hepatocellular carcinoma ; hepatectomy ; postoperative recurrence ; high mobility group box 1 protein
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-12-20
DOI: 10.3760/cma.j.issn.0366-6999.20142010
卷: 127, 期:24, 页:4171-4176
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: LYMPH-NODE METASTASIS ; SHOCK PROTEINS HSP27 ; GROUP BOX 1 ; PROGNOSTIC-SIGNIFICANCE ; POOR-PROGNOSIS ; GROWTH-FACTOR ; RISK-FACTORS ; EXPRESSION ; HEPATECTOMY ; SURVIVAL
英文摘要:

Background The management of Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) is controversial due to the early recurrence after curative hepatectonny, and many variables were related to the prognosis. The purpose of this study was to predict the tumor recurrence in early postoperative period of the patients with BCLC stage B HCC.

Methods From January 2004 to January 2012, 104 patients with BCLC stage B HCC underwent hepatectomy. Clinicopathological factors and follow-up data were statistically analyzed to establish a predicting scoring system.

Results The overall survival rates for one, three, and five years were 69.2%, 52.7%, and 42.3%, and the disease-free survival rates for one, three, and five years were 52.9%, 47.3%, and 37.5%, respectively. The multiple factors analysis showed that the micro-vessel invasion, lymph nodes metastasis, multiple lesions, and the high expression of HMGB1 were independent factors (P <0.05). A scoring system was established to predict the early recurrence within one year after the surgery for BCLC stage B HCC, according to the analysis results with a specificity of 85.1% and a sensitivity of 80.3%.

Conclusion Variant clinicopathological factors were associated with early postoperative recurrence for BCLC stage B HCC and recurrence early after hepatectomy was more likely in patients with a higher score of the scoring system.

语种: 英语
WOS记录号: WOS:000347276600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64582
Appears in Collections:北京大学临床肿瘤学院_肝胆胰外科_期刊论文

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作者单位: Peking Univ, Sch Oncol, Dept Hepatopancreatobiliary Surg, Beijing Canc Hosp, Beijing 100142, Peoples R China

Recommended Citation:
Qian Honggang,Wei Meng,Qiu Hui,et al. A scoring system for prediction of early recurrence after liver resection for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma[J]. CHINESE MEDICAL JOURNAL,2014,127(24):4171-4176.
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