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Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo
Xu, Kai-Hong1; Lu, Dao-Pei1,2
关键词Plumbagin Apoptosis Leukemia Reactive oxygen species Xenograft
刊名LEUKEMIA RESEARCH
2010-05-01
DOI10.1016/j.leukres.2009.08.017
34期:5页:658-665
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]BREAST-CANCER CELLS ; NF-KAPPA-B ; ARSENIC TRIOXIDE ; CYCLE ARREST ; CHEMOTHERAPEUTIC-AGENTS ; CASPASE ACTIVATION ; PROSTATE-CANCER ; PATHWAY ; MODULATION ; BCL-2
英文摘要

Plumbagin, a naphtoquinone from the roots of Plumbago zeylanica is known to possess anticancer and anti-bacterial activity. Based on the former finding of our group in vitro demonstrating its effectiveness in human promyelocytic leukemia cells, NB4, in this study we further revealed the mitochondrial pathway involved in plumbagin-induced apoptosis. We also found that the generation of ROS was a critical mediator in plumbagin-induced apoptosis, which would be abrogated completely by antioxidant, NAC. The anticancer effect of plumbagin was investigated in vivo using NB4 tumor xenograft in NOD/SCID mice. The incidence of formation, growth characteristics, body weight and volume of tumors were observed. The histopathologic examination of tumors and organs were made. The results showed that intraperitoneal injection of plumbagin (2 mg/kg body weight) daily for 3 weeks resulted to a 64.49% reduction of tumor volume compared with the control. Furthermore, there was no overt manifestation of toxicity such as weight loss, tissue damage and behavior change which appeared in Doxorubicin-treated mice (1 mg/kg thrice a week). These results indicate that plumbagin has potential as a novel therapeutic agent for myeloid leukemia. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000276945300018
引用统计
被引频次:51[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64587
专题北京大学第二临床医学院_血液科
作者单位1.Beijing Daopei Hosp, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
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Xu, Kai-Hong,Lu, Dao-Pei. Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo[J]. LEUKEMIA RESEARCH,2010,34(5):658-665.
APA Xu, Kai-Hong,&Lu, Dao-Pei.(2010).Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo.LEUKEMIA RESEARCH,34(5),658-665.
MLA Xu, Kai-Hong,et al."Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo".LEUKEMIA RESEARCH 34.5(2010):658-665.
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