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Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo
Xu, Kai-Hong1; Lu, Dao-Pei1,2
Source PublicationLEUKEMIA RESEARCH
2010-05-01
Volume34Issue:5Pages:658-665
Indexed BySCI
Abstract

Plumbagin, a naphtoquinone from the roots of Plumbago zeylanica is known to possess anticancer and anti-bacterial activity. Based on the former finding of our group in vitro demonstrating its effectiveness in human promyelocytic leukemia cells, NB4, in this study we further revealed the mitochondrial pathway involved in plumbagin-induced apoptosis. We also found that the generation of ROS was a critical mediator in plumbagin-induced apoptosis, which would be abrogated completely by antioxidant, NAC. The anticancer effect of plumbagin was investigated in vivo using NB4 tumor xenograft in NOD/SCID mice. The incidence of formation, growth characteristics, body weight and volume of tumors were observed. The histopathologic examination of tumors and organs were made. The results showed that intraperitoneal injection of plumbagin (2 mg/kg body weight) daily for 3 weeks resulted to a 64.49% reduction of tumor volume compared with the control. Furthermore, there was no overt manifestation of toxicity such as weight loss, tissue damage and behavior change which appeared in Doxorubicin-treated mice (1 mg/kg thrice a week). These results indicate that plumbagin has potential as a novel therapeutic agent for myeloid leukemia. (C) 2009 Elsevier Ltd. All rights reserved.

KeywordPlumbagin Apoptosis Leukemia Reactive Oxygen Species Xenograft
Subject Area临床医学
SubtypeArticle
DOI10.1016/j.leukres.2009.08.017
WOS HeadingsScience & Technology
Language英语
WOS Research AreaOncology ; Hematology
WOS SubjectOncology ; Hematology
WOS KeywordBREAST-CANCER CELLS ; NF-KAPPA-B ; ARSENIC TRIOXIDE ; CYCLE ARREST ; CHEMOTHERAPEUTIC-AGENTS ; CASPASE ACTIVATION ; PROSTATE-CANCER ; PATHWAY ; MODULATION ; BCL-2
WOS IDWOS:000276945300018
Citation statistics
Cited Times:73[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.bjmu.edu.cn/handle/400002259/64587
Collection北京大学第二临床医学院_血液科
Affiliation1.Beijing Daopei Hosp, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Xu, Kai-Hong,Lu, Dao-Pei. Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo[J]. LEUKEMIA RESEARCH,2010,34(5):658-665.
APA Xu, Kai-Hong,&Lu, Dao-Pei.(2010).Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo.LEUKEMIA RESEARCH,34(5),658-665.
MLA Xu, Kai-Hong,et al."Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo".LEUKEMIA RESEARCH 34.5(2010):658-665.
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