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学科主题: 临床医学
题名:
The environment, geoepidemiology and ANCA-associated vasculitides
作者: Chen, Min1,2; Kallenberg, Cees G. M.1
关键词: ANCA ; Vasculitides ; Environment ; Etiology ; Geoepidemiology
刊名: AUTOIMMUNITY REVIEWS
发表日期: 2010-03-01
DOI: 10.1016/j.autrev.2009.10.008
卷: 9, 期:5, 页:A293-A298
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES ; PARVOVIRUS B19 INFECTION ; AUTOANTIBODY-ASSOCIATED VASCULITIS ; WEGENERS-GRANULOMATOSIS ; SYSTEMIC VASCULITIS ; MICROSCOPIC POLYANGIITIS ; CHINESE PATIENTS ; ANTIMYELOPEROXIDASE ANTIBODIES ; ACTIVATED NEUTROPHILS ; OCCUPATIONAL-EXPOSURE
英文摘要:

Anti-neutrophil cytoplasmic antibodies, directed against constituents of granules of neutrophils and lysosomes of monocytes, are serological markers of small vessel vasculitides, including Wegener′s granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and renal-limited vasculitis. These vasculitides are collectively termed ANCA-associated vasculitides (AAV). Environmental factors have been considered important in the development of ANCA, including silica, infection especially with Staphylococcus aureus, and drugs. Accelerated apoptosis of neutrophils induced through intratracheal instillation of silica may act as a trigger in the development of AAV. Inhaled silica may activate alveolar macrophages and not only induce inflammation and activation of fibroblasts, but also stimulate lymphocytes through T-cell receptors and attract neutrophils. Staphylococcus aureus is associated with initiation and relapse of Wegener′s granulomatosis. Peptides from complementary PR3 show strong homology with peptides from S. aureus, which could underlie the development of PR3 ANCA. There is increasing recognition that drugs, especially propylthiouracil (PTU), may cause AAV. Patients with PTU-induced AAV have better prognosis than those with primary AAV. The disease spectrum of AAV in various geographic regions is different, which may suggest that the initiating factor in AAV has a different geographical distribution. Differences in genetic background may also be important in determining the response to triggering or initiating factors. (C) 2009 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000276470100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64597
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Univ Groningen, Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, NL-9700 RB Groningen, Netherlands

Recommended Citation:
Chen, Min,Kallenberg, Cees G. M.. The environment, geoepidemiology and ANCA-associated vasculitides[J]. AUTOIMMUNITY REVIEWS,2010,9(5):A293-A298.
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