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Disrupted resting-state functional connectivity in minimally treated chronic schizophrenia
Wang, Xijin1; Xia, Mingrui2; Lai, Yunyao3; Dai, Zhengjia2; Cao, Qingjiu1; Cheng, Zhang1; Han, Xue1; Yang, Lei1; Yuan, Yanbo1; Zhang, Yong4; Li, Keqing4; Ma, Hong1; Shi, Chuan1; Hong, Nan3; Szeszko, Philip5; Yu, Xin1; He, Yong2
关键词Schizophrenia Resting-state fMRI Connection distance Neuropsychology
刊名SCHIZOPHRENIA RESEARCH
2014-07-01
DOI10.1016/j.schres.2014.03.033
156期:2-3页:150-156
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]WORKING-MEMORY ; HUMAN BRAIN ; ANATOMICAL CONNECTIVITY ; HEAD MOTION ; NETWORKS ; FMRI ; MRI ; SYSTEMS ; DYSFUNCTION ; PERFORMANCE
英文摘要

Objective: The pathophysiology of chronic schizophrenia may reflect long term brain changes related to the disorder. The effect of chronicity on intrinsic functional connectivity patterns in schizophrenia without the potentially confounding effect of antipsychotic medications, however, remains largely unknown.

Method: We collected resting-state fMRI data in 21 minimally treated chronic schizophrenia patients and 20 healthy controls. We computed regional functional connectivity strength for each voxel in the brain, and further divided regional functional connectivity strength into short-range regional functional connectivity strength and long-range regional functional connectivity strength. General linear models were used to detect between-group differences in these regional functional connectivity strength metrics and to further systematically investigate the relationship between these differences and clinical/behavioral variables in the patients.

Results: Compared to healthy controls, the minimally treated chronic schizophrenia patients showed an overall reduced regional functional connectivity strength especially in bilateral sensorimotor cortex, right lateral prefrontal cortex, left insula and right lingual gyrus, and these regional functional connectivity strength decreases mainly resulted from disruption of short-range regional functional connectivity strength. The minimally treated chronic schizophrenia patients also showed reduced long-range regional functional connectivity strength in the bilateral posterior cingulate cortex/precuneus, and increased long-range regional functional connectivity strength in the right lateral prefrontal cortex and lingual gyrus. Notably, disrupted short-range regional functional connectivity strength mainly correlated with duration of illness and negative symptoms, whereas disrupted long-range regional functional connectivity strength correlated with neurocognitive performance. All of the results were corrected using Monte-Carlo simulation.

Conclusions: This exploratory study demonstrates a disruption of intrinsic functional connectivity without long-term exposure to antipsychotic medications in chronic schizophrenia. Furthermore, this disruption was connection-distance dependent, thus raising the possibility for differential neural pathways in neurocognitive impairment and psychiatric symptoms in schizophrenia. (C) 2014 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000341313200003
项目编号20100001110097 ; 2007BAI17B04 ; 985-2-027-39 ; 81225012 ; 81030028 ; 31221003
资助机构2010 Colleges and Universities Doctoral Program Specialized Research Fund of Peking University Health Science Center ; National Key Project of Scientific and Technical Supporting Programs - Ministry of Science and Technology of China ; Key Construction Program of the National "985" Project, Peking University Health Science Center ; National Science Fund for Distinguished Young Scholars ; Natural Science Foundation of China
引用统计
被引频次:40[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64602
专题北京大学精神卫生研究所
北京大学第二临床医学院_放射科
北京大学精神卫生研究所_科研处
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Inst Mental Hlth, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
3.Peking Univ, Peking Univ Peoples Hosp, Dept Radiol, Beijing 100044, Peoples R China
4.Sixth Peoples Hosp Hebei Prov, Baoding 071000, Hebei Province, Peoples R China
5.Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY 11030 USA
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GB/T 7714
Wang, Xijin,Xia, Mingrui,Lai, Yunyao,et al. Disrupted resting-state functional connectivity in minimally treated chronic schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2014,156(2-3):150-156.
APA Wang, Xijin.,Xia, Mingrui.,Lai, Yunyao.,Dai, Zhengjia.,Cao, Qingjiu.,...&He, Yong.(2014).Disrupted resting-state functional connectivity in minimally treated chronic schizophrenia.SCHIZOPHRENIA RESEARCH,156(2-3),150-156.
MLA Wang, Xijin,et al."Disrupted resting-state functional connectivity in minimally treated chronic schizophrenia".SCHIZOPHRENIA RESEARCH 156.2-3(2014):150-156.
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