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学科主题: 临床医学
题名:
Changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas
作者: Zhou, ZQ; Shi, XE
关键词: craniopharyngioma ; surgery ; hormone ; diabetes insipidus ; hypothyroidism
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2004-03-01
卷: 117, 期:3, 页:357-360
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: SURGICAL-MANAGEMENT ; ENDOCRINE
英文摘要:

Background This paper aimed to elucidate the changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas.

Methods A total of 40 patients with craniopharyngiomas received surgery. The levels of triiodothyronine (T-3), thyroxine (T-4), thyrotropic hormone (TSH), antidiuretic hormone (ADH), and adrenocorticotropin (ACTH) were measureed in the 40 patients before surgery and one week after surgery respectively.

Results Twenty-eight patients (70%) had hypothyroidism before surgery, but 38 (95%) had hypothyroidism after surgery P < 0.01). Twenty-three patients (57.5%) had diabetes insipidus ( DI) before surgery and 38 (95% had 131 after surgery ( P < 0.001). The pre- and post-operative levels of ADH were (2.49 +/- 0.30) pg/ml and (2.80 +/- 0.29) pg/ml respectively ( P > 0.05), whereas those of ACTH were (23.97 +/- 2.69) pg/ml and (15.60 +/- 1.91) pg/ml respectively (P<0.05).

Conclusions Hormone deficits after total removal of craniopharyngioma appear to be the common complication of surgery. Hypothyroidism and diabetes insipidus are more frequent after surgery than before surgery. Thyroxine and glucocorticoids should be administered routinely after total removal of craniopharyngioma.

语种: 英语
WOS记录号: WOS:000220634700008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64604
Appears in Collections:北京大学第二临床医学院_神经外科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Neurosurg, Beijing 100044, Peoples R China

Recommended Citation:
Zhou, ZQ,Shi, XE. Changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas[J]. CHINESE MEDICAL JOURNAL,2004,117(3):357-360.
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