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学科主题临床医学
Changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas
Zhou, ZQ; Shi, XE
关键词craniopharyngioma surgery hormone diabetes insipidus hypothyroidism
刊名CHINESE MEDICAL JOURNAL
2004-03-01
117期:3页:357-360
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]SURGICAL-MANAGEMENT ; ENDOCRINE
英文摘要

Background This paper aimed to elucidate the changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas.

Methods A total of 40 patients with craniopharyngiomas received surgery. The levels of triiodothyronine (T-3), thyroxine (T-4), thyrotropic hormone (TSH), antidiuretic hormone (ADH), and adrenocorticotropin (ACTH) were measureed in the 40 patients before surgery and one week after surgery respectively.

Results Twenty-eight patients (70%) had hypothyroidism before surgery, but 38 (95%) had hypothyroidism after surgery P < 0.01). Twenty-three patients (57.5%) had diabetes insipidus ( DI) before surgery and 38 (95% had 131 after surgery ( P < 0.001). The pre- and post-operative levels of ADH were (2.49 +/- 0.30) pg/ml and (2.80 +/- 0.29) pg/ml respectively ( P > 0.05), whereas those of ACTH were (23.97 +/- 2.69) pg/ml and (15.60 +/- 1.91) pg/ml respectively (P<0.05).

Conclusions Hormone deficits after total removal of craniopharyngioma appear to be the common complication of surgery. Hypothyroidism and diabetes insipidus are more frequent after surgery than before surgery. Thyroxine and glucocorticoids should be administered routinely after total removal of craniopharyngioma.

语种英语
WOS记录号WOS:000220634700008
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64604
Collection北京大学第二临床医学院_神经外科
作者单位Peking Univ, Peoples Hosp, Dept Neurosurg, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Zhou, ZQ,Shi, XE. Changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas[J]. CHINESE MEDICAL JOURNAL,2004,117(3):357-360.
APA Zhou, ZQ,&Shi, XE.(2004).Changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas.CHINESE MEDICAL JOURNAL,117(3),357-360.
MLA Zhou, ZQ,et al."Changes of hypothalamus-pituitary hormones in patients after total removal of craniopharyngiomas".CHINESE MEDICAL JOURNAL 117.3(2004):357-360.
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