学科主题基础医学
CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer
Su, Yu1,2; Lin, Yi3,4,5; Zhang, Lianhai3,4; Liu, Baocai1,2; Yuan, Wanqiong1,2; Mo, Xiaoning1,2; Wang, Xiaohong3,6; Li, Henan1,2; Xing, Xiaofang3,6; Cheng, Xiaojing3,6; Dong, Bin3,7; Hu, Ying3,8; Du, Hong3,8; Zhu, Yubing3,4; Ding, Ning3,4; Li, Jiyou3,7; Liu, Weili1,2; Ma, Yongzhen1,2,9; Qiu, Xiaoyan1,2; Ji, Jiafu3,4; Han, Wenling1,2
关键词CMTM3 gastric cancer MARVEL tumor suppressor gene survival
刊名CANCER SCIENCE
2014
DOI10.1111/cas.12304
105期:1页:26-34
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]MESENCHYMAL TRANSITION ; ANDROGEN RECEPTOR ; DOWN-REGULATION ; GENE ; EXPRESSION ; IDENTIFICATION ; TRANSCRIPTION ; METHYLATION ; TRICELLULIN ; CARCINOMA
英文摘要

The CKLF-like MARVEL transmembrane domain containing 3 (CMTM3) gene is a novel tumor suppressor with frequent epigenetic inactivation. In this study, we showed the role played by CMTM3 in gastric cancer cells as a tumor suppressor gene, and examined the correlation between CMTM3 expression and clinicopathological parameters using immunohistochemistry in gastric cancer patients with different pathological stages (n=350). We found that CMTM3 expression was reduced or silenced by epigenetic regulation in gastric cell lines, and dramatically downregulated in primary gastric cancer tissues. Restoration of CMTM3 significantly affected migration and invasion of AGS and SGC-7901 cells (P<0.001). In vivo experiments showed that peritoneal disseminated metastases were significantly suppressed by CMTM3 (P<0.001). We further showed that the expression of MMP2 and the phosphorylation of Erk1/2 were decreased when CMTM3 was restored. In addition, by immunohistochemical staining, we found that the expression of CMTM3 was remarkably weaker in gastric cancer tissues than in normal mucosae (P=0.008), and was significantly correlated with gender (P=0.033), tumor depth (P=0.049), stage (P=0.021), and histological grade (P=0.022). More importantly, CMTM3 expression was associated with prognosis in gastric cancer patients (P=0.041), and was a significant independent prognostic indicator (hazard ratio=0.704, 95% confidence interval, 0.498-0.994; P=0.046). Our findings indicate that CMTM3 regulates migration and invasion of gastric cancer cells. Moreover, CMTM3 is a candidate marker for prognosis of gastric cancer in the clinic.

语种英语
WOS记录号WOS:000331129900004
项目编号2011ZX09307-001-05 ; 30972780
资助机构National Key Technology RD Program ; National Natural Science Foundation of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64605
专题北京大学基础医学院_北京大学人类疾病基因研究中心
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
北京大学临床肿瘤学院_中心实验室
北京大学临床肿瘤学院_标本库
作者单位1.Minist Hlth, Key Lab Med Immunol, Beijing, Peoples R China
2.Shandong Med Coll, Dept Histol & Embryol, Linyi, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Ctr Human Dis Genom, Sch Basic Med Sci,Dept Immunol, Beijing 100871, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China
5.Peking Univ, Canc Hosp & Inst, Dept Surg, Beijing 100142, Peoples R China
6.Capital Med Univ, Beijing Tiantan Hosp, Dept Gen Surg, Beijing, Peoples R China
7.Peking Univ, Canc Hosp & Inst, Clin Gastr Canc Res Lab, Beijing 100142, Peoples R China
8.Peking Univ, Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
9.Peking Univ, Canc Hosp & Inst, Dept Tissue Bank, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Su, Yu,Lin, Yi,Zhang, Lianhai,et al. CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer[J]. CANCER SCIENCE,2014,105(1):26-34.
APA Su, Yu.,Lin, Yi.,Zhang, Lianhai.,Liu, Baocai.,Yuan, Wanqiong.,...&Han, Wenling.(2014).CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer.CANCER SCIENCE,105(1),26-34.
MLA Su, Yu,et al."CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer".CANCER SCIENCE 105.1(2014):26-34.
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