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学科主题: 基础医学
题名:
CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer
作者: Su, Yu1,2; Lin, Yi3,4,5; Zhang, Lianhai3,4; Liu, Baocai1,2; Yuan, Wanqiong1,2; Mo, Xiaoning1,2; Wang, Xiaohong3,6; Li, Henan1,2; Xing, Xiaofang3,6; Cheng, Xiaojing3,6; Dong, Bin3,7; Hu, Ying3,8; Du, Hong3,8; Zhu, Yubing3,4; Ding, Ning3,4; Li, Jiyou3,7; Liu, Weili1,2; Ma, Yongzhen1,2,9; Qiu, Xiaoyan1,2; Ji, Jiafu3,4; Han, Wenling1,2
关键词: CMTM3 ; gastric cancer ; MARVEL ; tumor suppressor gene ; survival
刊名: CANCER SCIENCE
发表日期: 2014
DOI: 10.1111/cas.12304
卷: 105, 期:1, 页:26-34
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: MESENCHYMAL TRANSITION ; ANDROGEN RECEPTOR ; DOWN-REGULATION ; GENE ; EXPRESSION ; IDENTIFICATION ; TRANSCRIPTION ; METHYLATION ; TRICELLULIN ; CARCINOMA
英文摘要:

The CKLF-like MARVEL transmembrane domain containing 3 (CMTM3) gene is a novel tumor suppressor with frequent epigenetic inactivation. In this study, we showed the role played by CMTM3 in gastric cancer cells as a tumor suppressor gene, and examined the correlation between CMTM3 expression and clinicopathological parameters using immunohistochemistry in gastric cancer patients with different pathological stages (n=350). We found that CMTM3 expression was reduced or silenced by epigenetic regulation in gastric cell lines, and dramatically downregulated in primary gastric cancer tissues. Restoration of CMTM3 significantly affected migration and invasion of AGS and SGC-7901 cells (P<0.001). In vivo experiments showed that peritoneal disseminated metastases were significantly suppressed by CMTM3 (P<0.001). We further showed that the expression of MMP2 and the phosphorylation of Erk1/2 were decreased when CMTM3 was restored. In addition, by immunohistochemical staining, we found that the expression of CMTM3 was remarkably weaker in gastric cancer tissues than in normal mucosae (P=0.008), and was significantly correlated with gender (P=0.033), tumor depth (P=0.049), stage (P=0.021), and histological grade (P=0.022). More importantly, CMTM3 expression was associated with prognosis in gastric cancer patients (P=0.041), and was a significant independent prognostic indicator (hazard ratio=0.704, 95% confidence interval, 0.498-0.994; P=0.046). Our findings indicate that CMTM3 regulates migration and invasion of gastric cancer cells. Moreover, CMTM3 is a candidate marker for prognosis of gastric cancer in the clinic.

语种: 英语
所属项目编号: 2011ZX09307-001-05 ; 30972780
项目资助者: National Key Technology RD Program ; National Natural Science Foundation of China
WOS记录号: WOS:000331129900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64605
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Minist Hlth, Key Lab Med Immunol, Beijing, Peoples R China
2.Shandong Med Coll, Dept Histol & Embryol, Linyi, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Ctr Human Dis Genom, Sch Basic Med Sci,Dept Immunol, Beijing 100871, Peoples R China
4.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China
5.Peking Univ, Canc Hosp & Inst, Dept Surg, Beijing 100142, Peoples R China
6.Capital Med Univ, Beijing Tiantan Hosp, Dept Gen Surg, Beijing, Peoples R China
7.Peking Univ, Canc Hosp & Inst, Clin Gastr Canc Res Lab, Beijing 100142, Peoples R China
8.Peking Univ, Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
9.Peking Univ, Canc Hosp & Inst, Dept Tissue Bank, Beijing 100142, Peoples R China

Recommended Citation:
Su, Yu,Lin, Yi,Zhang, Lianhai,et al. CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer[J]. CANCER SCIENCE,2014,105(1):26-34.
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