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Effects of atorvastatin on the Th1/Th2 polarization of ongoing experimental autoimmune myocarditis in Lewis rats
Liu, W; Li, WM; Gao, C; Sun, NL
关键词EAM idiopathic dilated cardiomyopathy HMG-CoA reductase inhibitor Th1/Th2 autoimmunity
刊名JOURNAL OF AUTOIMMUNITY
2005-12-01
DOI10.1016/j.jaut.2005.06.005
25期:4页:258-263
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]STATINS ; PARALYSIS ; DISEASE
英文摘要

Objective: Experimental autoimmune myocarditis (EAM) in rats is it T cell-mediated disorder and the involvement of Th1/Th2 unbalance has been demonstrated. This Study was designed to test the hypothesis that 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitor, atorvastatin, affects T cell-mediated autoimmunity through modulating the balance of Th1/Th2 and reduces the severity of EAM.

Methods: Myocarditis was induced in 23 Lewis rats by injection of porcine cardiac myosin. High-dose (10 mg/kg/day) or low-dose (1 mg/kg/day) atorvastatin or vehicle was administered orally for 3 weeks to rats with EAM at the same time Of irunnInization. Seven Lewis rats received neither immunization nor statins therapy were used as normal controls. On day 21 after immunization (the climax of inflammation), echocardiography was examined and the severity of myocarditis was evaluated by histopathological evaluation. The area ratio (affected/entire area percentage) of myocardial lesions was determined in histological sections. Heart weight/body weight ratio was determined and the serum lipid levels were measured. Levels of serum IFN-gamma, IL-2, IL-4 and IL-10 were Measured by ELISA.

Results: Cardiac function was improved in the two atorvastatin-treated groups compared to the untreated group. Heart weight/body weight ratio and the degree of inflammation were significantly lower in the two dosage statin-treated groups than that in the untreated one. Furthermore, treatment with atorvastatin decreased the expression levels of Th1 cytokine (IFN-gamma and IL-2), and increased the expression levels of Th2 cytokine (IL-4 and IL-10). Atorvastatin attenuated the histopathological severity of myocarditis. Plasma lipid levels did not differ between the groups.

Conclusions: Atorvastatin ameliorates EAM by inhibiting T cell responses and suppressing Th1-type and inflammatory cytokines production and this activity is independent of cholesterol reduction, whereas Th2-type cytokines production was promoted. Atorvastatin may have beneficial effects on myocarditis by modulating the Th1/Th2 balance. These results demonstrate an important role of Th1/Th2 polarization in the pathogenesis of EAM and suggest that HMG-CoA reductase blockade may be a promising new strategy for the treatment of organ specific autoimmune diseases. (c) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000234157800002
引用统计
被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64606
专题北京大学第二临床医学院_心血管内科
作者单位1.Harbin Med Coll, Affiliated Hosp 1, Dept Cardiol, Heilongjiang 150001, Peoples R China
2.Harbin Med Coll, Affiliated Hosp 1, Dept Neurosurg, Heilongjiang 150001, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
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Liu, W,Li, WM,Gao, C,et al. Effects of atorvastatin on the Th1/Th2 polarization of ongoing experimental autoimmune myocarditis in Lewis rats[J]. JOURNAL OF AUTOIMMUNITY,2005,25(4):258-263.
APA Liu, W,Li, WM,Gao, C,&Sun, NL.(2005).Effects of atorvastatin on the Th1/Th2 polarization of ongoing experimental autoimmune myocarditis in Lewis rats.JOURNAL OF AUTOIMMUNITY,25(4),258-263.
MLA Liu, W,et al."Effects of atorvastatin on the Th1/Th2 polarization of ongoing experimental autoimmune myocarditis in Lewis rats".JOURNAL OF AUTOIMMUNITY 25.4(2005):258-263.
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