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Preparation and characterizations of a novel deoxycholic acid-O-carboxymethylated chitosan-folic acid conjugates and self-aggregates
Wang, Feihu1; Zhang, Dianrui1; Duan, Cunxian1; Jia, Lejiao1; Feng, Feifei1; Liu, Yue1; Wang, Yancai1; Hao, Leilei1; Zhang, Qiang2
关键词O-carboxymethylated chitosan Deoxycholic acid Folic acid Self-aggregates
刊名CARBOHYDRATE POLYMERS
2011-03-17
DOI10.1016/j.carbpol.2011.01.017
84期:3页:1192-1200
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Chemistry ; Polymer Science
关键词[WOS]BLOCK-COPOLYMER MICELLES ; BEARING 5-BETA-CHOLANIC ACID ; GENE DELIVERY-SYSTEM ; IN-VITRO ; ASSEMBLED NANOPARTICLES ; PHYSICOCHEMICAL CHARACTERISTICS ; DRUG-DELIVERY ; ANTICANCER DRUGS ; POLYMER MICELLES ; BILE-ACIDS
英文摘要

O-carboxymethylated chitosan (OCMC) was firstly hydrophobically modified with various deoxycholic acid (DOCA) to obtain a novel kind of amphiphilic polymer, and then covalently bound with folic acid (FA) to develop a new potential cancer-targeted drug delivery system. Structural characterizations of the conjugates were investigated using FTIR, (1)H NMR and XRD. The physicochemical properties of self-aggregates in aqueous media were studied by (1)H NMR, zetasizer, zeta potential, fluorescence spectroscopy, and transmission electron microscopy (TEM). The mean diameter of self-aggregates in PBS solution (pH 7.4) decreased with the degree of substitution (DS) of DOCA increasing. Zeta potential of self-aggregates exhibited near -20 mV in PBS solution (pH 7.4), indicating these nanoparticles were covered with negatively charged OCMC shells. The critical aggregation concentrations (cac) of the conjugates were dependent on the DS of DOCA and were significantly lower than those of low molecular weight surfactants. TEM images demonstrated that the shape of self-aggregates was spherical. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000288231100046
项目编号2009CB930300
资助机构National Basic Research Program of China (973 Program)
引用统计
被引频次:59[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64607
专题北京大学药学院
作者单位1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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Wang, Feihu,Zhang, Dianrui,Duan, Cunxian,et al. Preparation and characterizations of a novel deoxycholic acid-O-carboxymethylated chitosan-folic acid conjugates and self-aggregates[J]. CARBOHYDRATE POLYMERS,2011,84(3):1192-1200.
APA Wang, Feihu.,Zhang, Dianrui.,Duan, Cunxian.,Jia, Lejiao.,Feng, Feifei.,...&Zhang, Qiang.(2011).Preparation and characterizations of a novel deoxycholic acid-O-carboxymethylated chitosan-folic acid conjugates and self-aggregates.CARBOHYDRATE POLYMERS,84(3),1192-1200.
MLA Wang, Feihu,et al."Preparation and characterizations of a novel deoxycholic acid-O-carboxymethylated chitosan-folic acid conjugates and self-aggregates".CARBOHYDRATE POLYMERS 84.3(2011):1192-1200.
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