|Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer|
|Yu, Yanming3; Jiang, Quan4; Miao, Yanwei5; Li, Jun3; Bao, Shanglian3; Wang, Haoyu3; Wu, Chunxue6; Wang, Xiaoying6; Zhu, Jiong7; Zhong, Yi8; Haacke, E. Mark1,2; Hu, Jiani1|
|WOS标题词||Science & Technology|
|类目[WOS]||Radiology, Nuclear Medicine & Medical Imaging|
|研究领域[WOS]||Radiology, Nuclear Medicine & Medical Imaging|
|关键词[WOS]||ARTERIAL INPUT FUNCTION ; REFERENCE TISSUE QUANTIFICATION ; DCE-MRI ; PRIMARY CHEMOTHERAPY ; PREOPERATIVE CHEMOTHERAPY ; PROGNOSTIC-SIGNIFICANCE ; T1 ; RELAXATION ; PERFUSION ; LESIONS|
Purpose: To develop a method that combines a fixed-T1, fuzzy c-means (FCM) technique with a reference region (RR) model (T1-FCM method) to estimate pharmacokinetic parameters without measuring the arterial input function or baseline T1, or T1(0), and to demonstrate its feasibility in the assessment of treatment response to neoadjuvant chemotherapy (NAC) in patients with breast cancer by using data from dynamic contrast material-enhanced magnetic resonance (MR) imaging.
Materials and Methods: This study was approved by the human investigation committees of the two participating institutions. All patients gave written informed consent. A conventional dual-flip-angle gradient-echo method was used to evaluate the effects of noise and the T1 in the tissue itself on the accuracy of T1 estimation. Both conventional RR and fixed-T1 methods were used to evaluate the effects of noise and preselected T1(0) on the estimation of pharmacokinetic parameters by means of a simulation study. Thirty-three women (age range, 32-66 years; mean age, 45 years) with pathologically proved breast tumors were examined to evaluate the feasibility of using the T1-FCM method as a means of assessing treatment response to NAC. A non-parametric Mann-Whitney U test was used to assess the difference in each of the MR imaging parameters between patients with a major histologic response to treatment and those with a nonmajor histologic response.
Results: With use of the dual-flip-angle method, the accuracy and distribution of T1 estimation are dependent on the T1 in the tissue itself. The T1-FCM method is more accurate than other methods and is relatively insensitive to the effects of noise and incorrect T1(0) selection. Preliminary clinical data revealed a significant difference (P < .01) in the change of the volume transfer constant after two cycles of NAC between the major and nonmajor histologic response groups.
Conclusion: Results of the simulation study demonstrate that the T1-FCM method appears to be relatively insensitive to noisy dynamic contrast-enhanced MR imaging data. This method could prove useful in the evaluation of breast cancer therapy. (C) RSNA, 2010
|项目编号||IMG0402881 ; 2006CB705705 ; 10527003 ; 60672104|
|资助机构||Susan G. Komen Breast Cancer Foundation ; Ministry of Science and Technology of China ; National Natural Science Foundation of China|
|作者单位||1.Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI USA|
2.MR Imaging Inst Biomed Res, Detroit, MI USA
3.Wayne State Univ, Sch Med, Harper Univ Hosp, MR Imaging Ctr Concourse,Dept Radiol, Detroit, MI 48201 USA
4.Peking Univ, Beijing Key Lab Med Phys & Engn, Beijing 100871, Peoples R China
5.Dalian Med Univ, Affiliated Hosp 1, Dept Radiol, Dalian, Liaoning, Peoples R China
6.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
7.Shanghai Jiao Tong Univ, Dept Radiol, Ren Ji Hosp, Sch Med, Shanghai 200030, Peoples R China
8.Northeastern Univ, Dept Sino Dutch Biomed & Informat Engn, Shenyang, Liaoning, Peoples R China
|Yu, Yanming,Jiang, Quan,Miao, Yanwei,et al. Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer[J]. RADIOLOGY,2010,257(1):47-55.|
|APA||Yu, Yanming.,Jiang, Quan.,Miao, Yanwei.,Li, Jun.,Bao, Shanglian.,...&Hu, Jiani.(2010).Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer.RADIOLOGY,257(1),47-55.|
|MLA||Yu, Yanming,et al."Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer".RADIOLOGY 257.1(2010):47-55.|