北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科  > 期刊论文
学科主题: 临床医学
题名:
Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer
作者: Yu, Yanming3; Jiang, Quan4; Miao, Yanwei5; Li, Jun3; Bao, Shanglian3; Wang, Haoyu3; Wu, Chunxue6; Wang, Xiaoying6; Zhu, Jiong7; Zhong, Yi8; Haacke, E. Mark1,2; Hu, Jiani1
刊名: RADIOLOGY
发表日期: 2010-10-01
DOI: 10.1148/radiol.10092169
卷: 257, 期:1, 页:47-55
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: ARTERIAL INPUT FUNCTION ; REFERENCE TISSUE QUANTIFICATION ; DCE-MRI ; PRIMARY CHEMOTHERAPY ; PREOPERATIVE CHEMOTHERAPY ; PROGNOSTIC-SIGNIFICANCE ; T1 ; RELAXATION ; PERFUSION ; LESIONS
英文摘要:

Purpose: To develop a method that combines a fixed-T1, fuzzy c-means (FCM) technique with a reference region (RR) model (T1-FCM method) to estimate pharmacokinetic parameters without measuring the arterial input function or baseline T1, or T1(0), and to demonstrate its feasibility in the assessment of treatment response to neoadjuvant chemotherapy (NAC) in patients with breast cancer by using data from dynamic contrast material-enhanced magnetic resonance (MR) imaging.

Materials and Methods: This study was approved by the human investigation committees of the two participating institutions. All patients gave written informed consent. A conventional dual-flip-angle gradient-echo method was used to evaluate the effects of noise and the T1 in the tissue itself on the accuracy of T1 estimation. Both conventional RR and fixed-T1 methods were used to evaluate the effects of noise and preselected T1(0) on the estimation of pharmacokinetic parameters by means of a simulation study. Thirty-three women (age range, 32-66 years; mean age, 45 years) with pathologically proved breast tumors were examined to evaluate the feasibility of using the T1-FCM method as a means of assessing treatment response to NAC. A non-parametric Mann-Whitney U test was used to assess the difference in each of the MR imaging parameters between patients with a major histologic response to treatment and those with a nonmajor histologic response.

Results: With use of the dual-flip-angle method, the accuracy and distribution of T1 estimation are dependent on the T1 in the tissue itself. The T1-FCM method is more accurate than other methods and is relatively insensitive to the effects of noise and incorrect T1(0) selection. Preliminary clinical data revealed a significant difference (P < .01) in the change of the volume transfer constant after two cycles of NAC between the major and nonmajor histologic response groups.

Conclusion: Results of the simulation study demonstrate that the T1-FCM method appears to be relatively insensitive to noisy dynamic contrast-enhanced MR imaging data. This method could prove useful in the evaluation of breast cancer therapy. (C) RSNA, 2010

语种: 英语
所属项目编号: IMG0402881 ; 2006CB705705 ; 10527003 ; 60672104
项目资助者: Susan G. Komen Breast Cancer Foundation ; Ministry of Science and Technology of China ; National Natural Science Foundation of China
WOS记录号: WOS:000282527200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64608
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI USA
2.MR Imaging Inst Biomed Res, Detroit, MI USA
3.Wayne State Univ, Sch Med, Harper Univ Hosp, MR Imaging Ctr Concourse,Dept Radiol, Detroit, MI 48201 USA
4.Peking Univ, Beijing Key Lab Med Phys & Engn, Beijing 100871, Peoples R China
5.Dalian Med Univ, Affiliated Hosp 1, Dept Radiol, Dalian, Liaoning, Peoples R China
6.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
7.Shanghai Jiao Tong Univ, Dept Radiol, Ren Ji Hosp, Sch Med, Shanghai 200030, Peoples R China
8.Northeastern Univ, Dept Sino Dutch Biomed & Informat Engn, Shenyang, Liaoning, Peoples R China

Recommended Citation:
Yu, Yanming,Jiang, Quan,Miao, Yanwei,et al. Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer[J]. RADIOLOGY,2010,257(1):47-55.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yu, Yanming]'s Articles
[Jiang, Quan]'s Articles
[Miao, Yanwei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yu, Yanming]‘s Articles
[Jiang, Quan]‘s Articles
[Miao, Yanwei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace