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Immune modulation and safety profile of adoptive immunotherapy using expanded autologous activated lymphocytes against advanced cancer
Sun, Zhao1; Shi, Liang2; Zhang, Huagang2; Shao, Yi2; Wang, Yu2; Lin, Yi1; Li, Xiaolin3; Bai, Chunmei1
关键词EAAL Adoptive immunotherapy IFN-gamma
刊名CLINICAL IMMUNOLOGY
2011
DOI10.1016/j.clim.2010.08.012
138期:1页:23-32
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]INDUCED KILLER-CELLS ; CD8(+) T-CELLS ; TUMOR-INFILTRATING LYMPHOCYTES ; SERUM INTERLEUKIN-10 LEVELS ; HIGH-DOSE INTERLEUKIN-2 ; RANDOMIZED-TRIAL ; IN-VITRO ; RECURRENCE RATES ; TRANSFER THERAPY ; SOLID TUMORS
英文摘要

Expanded activated autologous lymphocyte (EAAL) therapy with CD3(+)CD8(+) cytotoxic T lymphocyte and CD3(-)56(+) natural killer cell as the major effector cells is a type of adoptive cell therapy. In this study, 19 patients with metastatic tumors received EAAL therapy. Two to four weeks after the administration of EAAL cells, the subsets of CD3(+)CD8(+) T lymphocytes and CD3(-)CD56(+) natural killer cells in the peripheral blood were increased significantly in comparison with those before the therapy. The number of IFN-gamma secreting cells also significantly increased after the EAAL infusion (p = 0.002) and the p values for the counts of CD3(+)IFN-gamma(+) lymphocytes and CD3(-)IFN-gamma(+) lymphocytes were 0.006 and 0.015, respectively. Moreover, the percentage of IFN-gamma producing cells of the CD3(+), CD8(+) and CD3(-) subsets after infusion were all increased significantly, which indicated that EAAL therapy was able to enrich the potentially anti-tumor cytotoxic peripheral blood lymphocytes. (C) 2010 Published by Elsevier Inc.

语种英语
WOS记录号WOS:000286714000005
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64610
专题北京大学临床肿瘤学院
作者单位1.Chinese Acad Med Sci, Dept Oncol, Peking Union Med Coll, Beijing 100730, Peoples R China
2.Peking Univ, Beijing Canc Hosp, Beijing, Peoples R China
3.Hebei Med Univ, Affiliated Hosp 2, Dept Acupuncture & Moxibust, Shijiazhuang, Peoples R China
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Sun, Zhao,Shi, Liang,Zhang, Huagang,et al. Immune modulation and safety profile of adoptive immunotherapy using expanded autologous activated lymphocytes against advanced cancer[J]. CLINICAL IMMUNOLOGY,2011,138(1):23-32.
APA Sun, Zhao.,Shi, Liang.,Zhang, Huagang.,Shao, Yi.,Wang, Yu.,...&Bai, Chunmei.(2011).Immune modulation and safety profile of adoptive immunotherapy using expanded autologous activated lymphocytes against advanced cancer.CLINICAL IMMUNOLOGY,138(1),23-32.
MLA Sun, Zhao,et al."Immune modulation and safety profile of adoptive immunotherapy using expanded autologous activated lymphocytes against advanced cancer".CLINICAL IMMUNOLOGY 138.1(2011):23-32.
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