北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 期刊论文
学科主题: 临床医学
题名:
Immune modulation and safety profile of adoptive immunotherapy using expanded autologous activated lymphocytes against advanced cancer
作者: Sun, Zhao1; Shi, Liang2; Zhang, Huagang2; Shao, Yi2; Wang, Yu2; Lin, Yi1; Li, Xiaolin3; Bai, Chunmei1
关键词: EAAL ; Adoptive immunotherapy ; IFN-gamma
刊名: CLINICAL IMMUNOLOGY
发表日期: 2011
DOI: 10.1016/j.clim.2010.08.012
卷: 138, 期:1, 页:23-32
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: INDUCED KILLER-CELLS ; CD8(+) T-CELLS ; TUMOR-INFILTRATING LYMPHOCYTES ; SERUM INTERLEUKIN-10 LEVELS ; HIGH-DOSE INTERLEUKIN-2 ; RANDOMIZED-TRIAL ; IN-VITRO ; RECURRENCE RATES ; TRANSFER THERAPY ; SOLID TUMORS
英文摘要:

Expanded activated autologous lymphocyte (EAAL) therapy with CD3(+)CD8(+) cytotoxic T lymphocyte and CD3(-)56(+) natural killer cell as the major effector cells is a type of adoptive cell therapy. In this study, 19 patients with metastatic tumors received EAAL therapy. Two to four weeks after the administration of EAAL cells, the subsets of CD3(+)CD8(+) T lymphocytes and CD3(-)CD56(+) natural killer cells in the peripheral blood were increased significantly in comparison with those before the therapy. The number of IFN-gamma secreting cells also significantly increased after the EAAL infusion (p = 0.002) and the p values for the counts of CD3(+)IFN-gamma(+) lymphocytes and CD3(-)IFN-gamma(+) lymphocytes were 0.006 and 0.015, respectively. Moreover, the percentage of IFN-gamma producing cells of the CD3(+), CD8(+) and CD3(-) subsets after infusion were all increased significantly, which indicated that EAAL therapy was able to enrich the potentially anti-tumor cytotoxic peripheral blood lymphocytes. (C) 2010 Published by Elsevier Inc.

语种: 英语
WOS记录号: WOS:000286714000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64610
Appears in Collections:北京大学临床肿瘤学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Med Sci, Dept Oncol, Peking Union Med Coll, Beijing 100730, Peoples R China
2.Peking Univ, Beijing Canc Hosp, Beijing, Peoples R China
3.Hebei Med Univ, Affiliated Hosp 2, Dept Acupuncture & Moxibust, Shijiazhuang, Peoples R China

Recommended Citation:
Sun, Zhao,Shi, Liang,Zhang, Huagang,et al. Immune modulation and safety profile of adoptive immunotherapy using expanded autologous activated lymphocytes against advanced cancer[J]. CLINICAL IMMUNOLOGY,2011,138(1):23-32.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Sun, Zhao]'s Articles
[Shi, Liang]'s Articles
[Zhang, Huagang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Sun, Zhao]‘s Articles
[Shi, Liang]‘s Articles
[Zhang, Huagang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace