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学科主题: 临床医学
题名:
Progression and variation of fatty infiltration of the thigh muscles in Duchenne muscular dystrophy, a muscle magnetic resonance imaging study
作者: Li, Wenzhu1; Zheng, Yiming1; Zhang, Wei1; Wang, Zhaoxia1; Xiao, Jiangxi2; Yuan, Yun1
关键词: Duchenne muscular dystrophy ; Muscle magnetic resonance imaging ; Fatty infiltration ; Age
刊名: NEUROMUSCULAR DISORDERS
发表日期: 2015-05-01
DOI: 10.1016/j.nmd.2015.01.003
卷: 25, 期:5, 页:375-380
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CLINICAL-ASSESSMENTS ; DISEASE PROGRESSION ; BOYS ; MRI ; PROTEIN ; AGE ; QUANTIFICATION ; INVOLVEMENT ; PHENOTYPE ; CHILDREN
英文摘要:

The purpose of this study was to assess the progression and variation of fatty infiltration of the thigh muscles of Duchenne muscular dystrophy patients. Muscle magnetic resonance imaging was used to measure the degree of fatty infiltration of the thigh muscles of 171 boys with Duchenne muscular dystrophy (mean age, 6.09 +/- 2.30 years). Fatty infiltration was assigned using a modified Mercuri′s scale 0-5 (normal-severe). The gluteus maximus and adductor magnus were affected in patients less than two years old, followed by the biceps femoris. Quadriceps and semitnembranosus were first affected at the age of five to six years; the sartorius, gracilis and adductor longus remained apparently unaffected until seven years of age. Fatty infiltration of all the thigh muscles developed rapidly after seven years of age. The standard deviation of the fatty infiltration scores ranged from 2.41 to 4.87 before five years old, and from 6.84 to 11.66 between six and ten years old. This study provides evidence of highly variable degrees of fatty infiltration in children of different ages with Duchenne muscular dystrophy, and indicates that fatty infiltration progresses more quickly after seven years of age. These findings may be beneficial for the selection of therapeutic regimens and the analysis of future clinical trials. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2010DFA31070
项目资助者: international cooperation project of the Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000354144000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64619
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China

Recommended Citation:
Li, Wenzhu,Zheng, Yiming,Zhang, Wei,et al. Progression and variation of fatty infiltration of the thigh muscles in Duchenne muscular dystrophy, a muscle magnetic resonance imaging study[J]. NEUROMUSCULAR DISORDERS,2015,25(5):375-380.
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