北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病原生物学系  > 期刊论文
学科主题: 基础医学
题名:
Genetic characteristics and pathogenicity of human hepatitis E virus in Nanjing, China
作者: Geng, Jia-Bao1; Wang, Mao-Rong1; Wang, Ling2; Wang, Jie1; Yang, Zhi-Guo1; Cheng, Yan1; Qiao, Fei1; Wang, Min1
关键词: Genotype ; Hepatitis E virus ; Liver failure ; Zoonotic transmission ; Pathogenicity
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2012-03-07
DOI: 10.3748/wjg.v18.i9.965
卷: 18, 期:9, 页:965-970
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: DEVELOPED-COUNTRIES ; NORTHERN UGANDA ; LARGE OUTBREAK ; ENDEMIC AREA ; INFECTION ; TRANSMISSION ; GENOTYPE ; DISEASE ; SWINE ; PREVALENCE
英文摘要:

AIM: To investigate the genetic characteristics and pathogenicity of hepatitis E virus (HEV) and assess the potential risk factors for sporadic hepatitis E.

METHODS: Sixty-two serum samples from the patients with acute hepatitis E were collected, including 23 cases coinfected with hepatitis B virus. Anti-HEV detection and partial HEV RNA amplification were performed by enzyme immunoassays and reverse transcription-nested polymerase chain reaction (RT-nPCR) method, respectively, and PCR products were sequenced. The isolated human HEV sequences were analyzed phylogenetically.

RESULTS: The positive rate of serum HEV RNA were 21.0% (13/62), including 5 cases of liver failure. All the 13 isolates shared a 82.1%-98.0% nucleotide homology with each other and had identities of 74.7%-81.0%, 75.3%-78.6%, 75.3%-80.0% and 82.1%-96.1% with the corresponding regions of HEV genotypes 1-4, respectively. The human HEV strain GS-NJ-12 shared a 100% nucleotide identity with the swine HEV strain swIM6-43 isolated from Inner Mongolia, China.

CONCLUSION: Swine may be a principal risk factor for occurrence of sporadic hepatitis E in eastern China, and genotype 4 HEV can induce acute liver failure. (C) 2012 Baishideng. All rights reserved.

语种: 英语
所属项目编号: 2006A02Z453 ; 30570063
项目资助者: 863 National High Technology Research ; Development Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000301397000014
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64621
Appears in Collections:基础医学院_病原生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Genetic characteristics and pathogenicity of human hepatitis E virus in Nanjing, China.pdf(749KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Nanjing Bayi Hosp, Inst Liver Dis, Nanjing 210002, Jiangsu, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100091, Peoples R China

Recommended Citation:
Geng, Jia-Bao,Wang, Mao-Rong,Wang, Ling,et al. Genetic characteristics and pathogenicity of human hepatitis E virus in Nanjing, China[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2012,18(9):965-970.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Geng, Jia-Bao]'s Articles
[Wang, Mao-Rong]'s Articles
[Wang, Ling]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Geng, Jia-Bao]‘s Articles
[Wang, Mao-Rong]‘s Articles
[Wang, Ling]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace