IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Genetic characteristics and pathogenicity of human hepatitis E virus in Nanjing, China
Geng, Jia-Bao1; Wang, Mao-Rong1; Wang, Ling2; Wang, Jie1; Yang, Zhi-Guo1; Cheng, Yan1; Qiao, Fei1; Wang, Min1
关键词Genotype Hepatitis E virus Liver failure Zoonotic transmission Pathogenicity
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2012-03-07
DOI10.3748/wjg.v18.i9.965
18期:9页:965-970
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]DEVELOPED-COUNTRIES ; NORTHERN UGANDA ; LARGE OUTBREAK ; ENDEMIC AREA ; INFECTION ; TRANSMISSION ; GENOTYPE ; DISEASE ; SWINE ; PREVALENCE
英文摘要

AIM: To investigate the genetic characteristics and pathogenicity of hepatitis E virus (HEV) and assess the potential risk factors for sporadic hepatitis E.

METHODS: Sixty-two serum samples from the patients with acute hepatitis E were collected, including 23 cases coinfected with hepatitis B virus. Anti-HEV detection and partial HEV RNA amplification were performed by enzyme immunoassays and reverse transcription-nested polymerase chain reaction (RT-nPCR) method, respectively, and PCR products were sequenced. The isolated human HEV sequences were analyzed phylogenetically.

RESULTS: The positive rate of serum HEV RNA were 21.0% (13/62), including 5 cases of liver failure. All the 13 isolates shared a 82.1%-98.0% nucleotide homology with each other and had identities of 74.7%-81.0%, 75.3%-78.6%, 75.3%-80.0% and 82.1%-96.1% with the corresponding regions of HEV genotypes 1-4, respectively. The human HEV strain GS-NJ-12 shared a 100% nucleotide identity with the swine HEV strain swIM6-43 isolated from Inner Mongolia, China.

CONCLUSION: Swine may be a principal risk factor for occurrence of sporadic hepatitis E in eastern China, and genotype 4 HEV can induce acute liver failure. (C) 2012 Baishideng. All rights reserved.

语种英语
WOS记录号WOS:000301397000014
项目编号2006A02Z453 ; 30570063
资助机构863 National High Technology Research ; Development Program of China ; National Natural Science Foundation of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64621
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Nanjing Bayi Hosp, Inst Liver Dis, Nanjing 210002, Jiangsu, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100091, Peoples R China
推荐引用方式
GB/T 7714
Geng, Jia-Bao,Wang, Mao-Rong,Wang, Ling,et al. Genetic characteristics and pathogenicity of human hepatitis E virus in Nanjing, China[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2012,18(9):965-970.
APA Geng, Jia-Bao.,Wang, Mao-Rong.,Wang, Ling.,Wang, Jie.,Yang, Zhi-Guo.,...&Wang, Min.(2012).Genetic characteristics and pathogenicity of human hepatitis E virus in Nanjing, China.WORLD JOURNAL OF GASTROENTEROLOGY,18(9),965-970.
MLA Geng, Jia-Bao,et al."Genetic characteristics and pathogenicity of human hepatitis E virus in Nanjing, China".WORLD JOURNAL OF GASTROENTEROLOGY 18.9(2012):965-970.
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