IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Fabrication and Characterization of Chitosan/PVA with Hydroxyapatite Biocomposite Nanoscaffolds
Yang, Dongzhi1; Jin, Yu1; Ma, Guiping1; Chen, Xiangmei2; Lu, Fengmin2; Nie, Jun1
关键词electrospinning chitosan hydroxyapatite biocomposite nano-scaffold
刊名JOURNAL OF APPLIED POLYMER SCIENCE
2008-12-15
DOI10.1002/app.28829
110期:6页:3328-3335
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Polymer Science
研究领域[WOS]Polymer Science
关键词[WOS]IN-VITRO ; MECHANICAL-PROPERTIES ; NANOFIBERS ; BONE ; REGENERATION ; SCAFFOLD ; FIBERS
英文摘要

Nanofibrous biocomposite scaffolds of chitosan (CS), PVA, and hydroxyapatite (HA) were prepared by electrospinning. The scaffolds were characterized by FTIR, SEM, TEM, and XRD techniques. Tensile testing was used for the characterization of mechanical properties. Mouse fibroblasts (L929) attachment and proliferation on the nano-fibrous scaffold were investigated by MTT assay and SEM observation. FTIR, TEM, and XRD results showed the presence of nanoHA in the scaffolds. The scaffolds have porous nanofibrous morphology with random fibers in the range of 100-700 nm diameters. The CS/PVA (90/10) fibrous matrix (Without HA) showed a tensile strength of 3.1 +/- 0.2 MPa and a tensile modulus 10 I MPa with a strain at failure of 21.1 +/- 0.6%. Increase the content of HA up to 2% increased the ultimate tensile strength and tensile modulus, but further increase HA LIP to 5-10% caused the decrease of tensile strength and tensile modulus. The attachment and growth of mouse fibroblast was on the Surface of nanofibrous structure, and cells′ morphology characteristics and viability were unaffected. A combination of nanofibrous CS/PVA and HA that mimics the nanoscale features of the extra cellular matrix Could be promising for application as scaffolds for tissue regeneration, especially in low or nonload bearing areas. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 110: 3328-3335, 2008

语种英语
WOS记录号WOS:000260587000004
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64623
Collection北京大学基础医学院_病原生物学系
作者单位1.Beijing Univ Chem Technol, Coll Mat Sci & Engn, Key Lab Beijing City Preparat & Proc Novel Polym, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
2.Peking Univ Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Yang, Dongzhi,Jin, Yu,Ma, Guiping,et al. Fabrication and Characterization of Chitosan/PVA with Hydroxyapatite Biocomposite Nanoscaffolds[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2008,110(6):3328-3335.
APA Yang, Dongzhi,Jin, Yu,Ma, Guiping,Chen, Xiangmei,Lu, Fengmin,&Nie, Jun.(2008).Fabrication and Characterization of Chitosan/PVA with Hydroxyapatite Biocomposite Nanoscaffolds.JOURNAL OF APPLIED POLYMER SCIENCE,110(6),3328-3335.
MLA Yang, Dongzhi,et al."Fabrication and Characterization of Chitosan/PVA with Hydroxyapatite Biocomposite Nanoscaffolds".JOURNAL OF APPLIED POLYMER SCIENCE 110.6(2008):3328-3335.
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