IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Fabrication and Characterization of Chitosan/PVA with Hydroxyapatite Biocomposite Nanoscaffolds
Yang, Dongzhi1; Jin, Yu1; Ma, Guiping1; Chen, Xiangmei2; Lu, Fengmin2; Nie, Jun1
关键词electrospinning chitosan hydroxyapatite biocomposite nano-scaffold
刊名JOURNAL OF APPLIED POLYMER SCIENCE
2008-12-15
DOI10.1002/app.28829
110期:6页:3328-3335
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Polymer Science
研究领域[WOS]Polymer Science
关键词[WOS]IN-VITRO ; MECHANICAL-PROPERTIES ; NANOFIBERS ; BONE ; REGENERATION ; SCAFFOLD ; FIBERS
英文摘要

Nanofibrous biocomposite scaffolds of chitosan (CS), PVA, and hydroxyapatite (HA) were prepared by electrospinning. The scaffolds were characterized by FTIR, SEM, TEM, and XRD techniques. Tensile testing was used for the characterization of mechanical properties. Mouse fibroblasts (L929) attachment and proliferation on the nano-fibrous scaffold were investigated by MTT assay and SEM observation. FTIR, TEM, and XRD results showed the presence of nanoHA in the scaffolds. The scaffolds have porous nanofibrous morphology with random fibers in the range of 100-700 nm diameters. The CS/PVA (90/10) fibrous matrix (Without HA) showed a tensile strength of 3.1 +/- 0.2 MPa and a tensile modulus 10 I MPa with a strain at failure of 21.1 +/- 0.6%. Increase the content of HA up to 2% increased the ultimate tensile strength and tensile modulus, but further increase HA LIP to 5-10% caused the decrease of tensile strength and tensile modulus. The attachment and growth of mouse fibroblast was on the Surface of nanofibrous structure, and cells′ morphology characteristics and viability were unaffected. A combination of nanofibrous CS/PVA and HA that mimics the nanoscale features of the extra cellular matrix Could be promising for application as scaffolds for tissue regeneration, especially in low or nonload bearing areas. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 110: 3328-3335, 2008

语种英语
WOS记录号WOS:000260587000004
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64623
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
北京大学公共卫生学院_公共卫生学院
作者单位1.Beijing Univ Chem Technol, Coll Mat Sci & Engn, Key Lab Beijing City Preparat & Proc Novel Polym, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
2.Peking Univ Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yang, Dongzhi,Jin, Yu,Ma, Guiping,et al. Fabrication and Characterization of Chitosan/PVA with Hydroxyapatite Biocomposite Nanoscaffolds[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2008,110(6):3328-3335.
APA Yang, Dongzhi,Jin, Yu,Ma, Guiping,Chen, Xiangmei,Lu, Fengmin,&Nie, Jun.(2008).Fabrication and Characterization of Chitosan/PVA with Hydroxyapatite Biocomposite Nanoscaffolds.JOURNAL OF APPLIED POLYMER SCIENCE,110(6),3328-3335.
MLA Yang, Dongzhi,et al."Fabrication and Characterization of Chitosan/PVA with Hydroxyapatite Biocomposite Nanoscaffolds".JOURNAL OF APPLIED POLYMER SCIENCE 110.6(2008):3328-3335.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Fabrication and Char(404KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Dongzhi]的文章
[Jin, Yu]的文章
[Ma, Guiping]的文章
百度学术
百度学术中相似的文章
[Yang, Dongzhi]的文章
[Jin, Yu]的文章
[Ma, Guiping]的文章
必应学术
必应学术中相似的文章
[Yang, Dongzhi]的文章
[Jin, Yu]的文章
[Ma, Guiping]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Fabrication and Characterization of Chitosan_PVA with Hydroxyapatite Biocomposite Nanoscaffolds.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。