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学科主题临床医学
Cyclic AMP-Responsive Element Modulator alpha Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus
Guo, Qian; Chen, Xuyong; Du, Yan; Guo, Jianping; Su, Yin
刊名JOURNAL OF IMMUNOLOGY RESEARCH
2015
DOI10.1155/2015/906086
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
资助者National Key Basic Research Program of China ; National Natural Science Foundation of China ; National Key Basic Research Program of China ; National Natural Science Foundation of China
研究领域[WOS]Immunology
关键词[WOS]T-CELLS ; INTERLEUKIN-2 ; EXPRESSION ; SUSCEPTIBILITY ; METAANALYSIS ; PROMOTER ; LOCI ; SLE ; ASSOCIATION ; INCREASES
英文摘要

To investigate whether the cyclic AMP-responsive element modulator alpha (CREM alpha) polymorphisms are novel susceptibility factors for systemic lupus erythematosus (SLE), four tag SNPs, rs1057108, rs2295415, rs11592925, and rs1148247, were genotyped in 889 SLE cases and 825 healthy controls. Association analyses were performed on whole dataset or clinical/serologic subsets. Association statistics were calculated by age and sex adjusted logistic regression. The G allele frequencies of rs2295415 and rs1057108 were increased in SLE patients, compared with healthy controls (rs2295415: 21.2% versus 17.8%, OR 1.244, P = 0.019; rs1057108: 30.8% versus 27.7%, OR 1.165, P = 0.049). The haplotype constituted by the two risk alleles "G-G" from rs1057108 and rs2295415 displayed strong association with SLE susceptibility (OR 1.454, P = 0.00056). Following stratification by clinical/serologic features, a suggestive association was observed between rs2295415 and anti-Sm antibodies-positive SLE (OR 1.382, P = 0.044). Interestingly, a potential protective effect of rs2295415 was observed for SLE patients with renal disorder (OR 0.745, P = 0.032). Our data provide first evidence that CREM alpha SNPs rs2295415 and rs1057108 maybe novel genetic susceptibility factors for SLE. SNP rs2295415 appears to confer higher risk to develop anti-Sm antibodies-positive SLE and may play a protective role against lupus nephritis.

语种英语
所属项目编号2014CB541901 ; 81172814 ; 81471600 ; 31470875
资助者National Key Basic Research Program of China ; National Natural Science Foundation of China ; National Key Basic Research Program of China ; National Natural Science Foundation of China
WOS记录号WOS:000364716600001
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64624
专题北京大学第二临床医学院
作者单位Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
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GB/T 7714
Guo, Qian,Chen, Xuyong,Du, Yan,et al. Cyclic AMP-Responsive Element Modulator alpha Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2015.
APA Guo, Qian,Chen, Xuyong,Du, Yan,Guo, Jianping,&Su, Yin.(2015).Cyclic AMP-Responsive Element Modulator alpha Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus.JOURNAL OF IMMUNOLOGY RESEARCH.
MLA Guo, Qian,et al."Cyclic AMP-Responsive Element Modulator alpha Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus".JOURNAL OF IMMUNOLOGY RESEARCH (2015).
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