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学科主题: 临床医学
题名:
Cyclic AMP-Responsive Element Modulator alpha Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus
作者: Guo, Qian; Chen, Xuyong; Du, Yan; Guo, Jianping; Su, Yin
刊名: JOURNAL OF IMMUNOLOGY RESEARCH
发表日期: 2015
DOI: 10.1155/2015/906086
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: T-CELLS ; INTERLEUKIN-2 ; EXPRESSION ; SUSCEPTIBILITY ; METAANALYSIS ; PROMOTER ; LOCI ; SLE ; ASSOCIATION ; INCREASES
英文摘要:

To investigate whether the cyclic AMP-responsive element modulator alpha (CREM alpha) polymorphisms are novel susceptibility factors for systemic lupus erythematosus (SLE), four tag SNPs, rs1057108, rs2295415, rs11592925, and rs1148247, were genotyped in 889 SLE cases and 825 healthy controls. Association analyses were performed on whole dataset or clinical/serologic subsets. Association statistics were calculated by age and sex adjusted logistic regression. The G allele frequencies of rs2295415 and rs1057108 were increased in SLE patients, compared with healthy controls (rs2295415: 21.2% versus 17.8%, OR 1.244, P = 0.019; rs1057108: 30.8% versus 27.7%, OR 1.165, P = 0.049). The haplotype constituted by the two risk alleles "G-G" from rs1057108 and rs2295415 displayed strong association with SLE susceptibility (OR 1.454, P = 0.00056). Following stratification by clinical/serologic features, a suggestive association was observed between rs2295415 and anti-Sm antibodies-positive SLE (OR 1.382, P = 0.044). Interestingly, a potential protective effect of rs2295415 was observed for SLE patients with renal disorder (OR 0.745, P = 0.032). Our data provide first evidence that CREM alpha SNPs rs2295415 and rs1057108 maybe novel genetic susceptibility factors for SLE. SNP rs2295415 appears to confer higher risk to develop anti-Sm antibodies-positive SLE and may play a protective role against lupus nephritis.

语种: 英语
所属项目编号: 2014CB541901 ; 81172814 ; 81471600 ; 31470875
项目资助者: National Key Basic Research Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000364716600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64624
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China

Recommended Citation:
Guo, Qian,Chen, Xuyong,Du, Yan,et al. Cyclic AMP-Responsive Element Modulator alpha Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2015.
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