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Bioavailability of tramadol hydrochloride after administration via different routes in rats
Zhang, Hua; Zhao, Youyou; Wang, Xueqing; Zhang, Qiang
关键词tramadol hydrochloride HPLC nasal administration buccal administration bioavailability
刊名BIOPHARMACEUTICS & DRUG DISPOSITION
2014-12-01
DOI10.1002/bdd.1916
35期:9页:525-531
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]DRUG-DELIVERY ; CONTROLLED-RELEASE ; IN-VITRO ; PHARMACOKINETICS ; CHROMATOGRAPHY ; PLASMA
英文摘要

Tramadol is a synthetic non-opiate analgesic drug and effective for many kinds of chronic and acute pain. This study compared the bioavailability of tramadol after different administration routes in rats (oral, buccal and nasal). A simple HPLC analytical approach was used to determine the concentration of tramadol in plasma. The pharmacokinetic behavior and bioavailability of tramadol after administration via different routes in rats were investigated. Nasal and buccal administration of tramadol resulted in a fast increase followed by a rapid decrease in the plasma tramadol concentration. The C-max values following buccal and nasal administration were 6 times and 20 times higher than that of oral administration, respectively, (6827.85 +/- 7970.87ng/ml, 22191.84 +/- 5364.86ng/ml, vs 1127.03 +/- 778.34ng/ml). The relative bioavailabilities of the nasal- and buccal-administered drug when compared with the oral route were 504.8% and 183.4%, respectively, which is much higher than that of oral administration. Nasal and buccal administration increased the bioavailability of tramadol, which may allow for a reduction in the dose of tramadol and a subsequent decrease in both side effects and toxicity. Therefore, this approach provides an effective choice for the delivery of tramadol, an analgesic drug. Copyright (c) 2014 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000346582500003
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64626
专题北京大学药学院_药剂学系
作者单位Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Hua,Zhao, Youyou,Wang, Xueqing,et al. Bioavailability of tramadol hydrochloride after administration via different routes in rats[J]. BIOPHARMACEUTICS & DRUG DISPOSITION,2014,35(9):525-531.
APA Zhang, Hua,Zhao, Youyou,Wang, Xueqing,&Zhang, Qiang.(2014).Bioavailability of tramadol hydrochloride after administration via different routes in rats.BIOPHARMACEUTICS & DRUG DISPOSITION,35(9),525-531.
MLA Zhang, Hua,et al."Bioavailability of tramadol hydrochloride after administration via different routes in rats".BIOPHARMACEUTICS & DRUG DISPOSITION 35.9(2014):525-531.
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