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学科主题: 药学
题名:
Bioavailability of tramadol hydrochloride after administration via different routes in rats
作者: Zhang, Hua; Zhao, Youyou; Wang, Xueqing; Zhang, Qiang
关键词: tramadol hydrochloride ; HPLC ; nasal administration ; buccal administration ; bioavailability
刊名: BIOPHARMACEUTICS & DRUG DISPOSITION
发表日期: 2014-12-01
DOI: 10.1002/bdd.1916
卷: 35, 期:9, 页:525-531
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DRUG-DELIVERY ; CONTROLLED-RELEASE ; IN-VITRO ; PHARMACOKINETICS ; CHROMATOGRAPHY ; PLASMA
英文摘要:

Tramadol is a synthetic non-opiate analgesic drug and effective for many kinds of chronic and acute pain. This study compared the bioavailability of tramadol after different administration routes in rats (oral, buccal and nasal). A simple HPLC analytical approach was used to determine the concentration of tramadol in plasma. The pharmacokinetic behavior and bioavailability of tramadol after administration via different routes in rats were investigated. Nasal and buccal administration of tramadol resulted in a fast increase followed by a rapid decrease in the plasma tramadol concentration. The C-max values following buccal and nasal administration were 6 times and 20 times higher than that of oral administration, respectively, (6827.85 +/- 7970.87ng/ml, 22191.84 +/- 5364.86ng/ml, vs 1127.03 +/- 778.34ng/ml). The relative bioavailabilities of the nasal- and buccal-administered drug when compared with the oral route were 504.8% and 183.4%, respectively, which is much higher than that of oral administration. Nasal and buccal administration increased the bioavailability of tramadol, which may allow for a reduction in the dose of tramadol and a subsequent decrease in both side effects and toxicity. Therefore, this approach provides an effective choice for the delivery of tramadol, an analgesic drug. Copyright (c) 2014 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000346582500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64626
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Hua,Zhao, Youyou,Wang, Xueqing,et al. Bioavailability of tramadol hydrochloride after administration via different routes in rats[J]. BIOPHARMACEUTICS & DRUG DISPOSITION,2014,35(9):525-531.
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