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学科主题临床医学
Nomogram Predicting Renal Insufficiency after Nephroureterectomy for Upper Tract Urothelial Carcinoma in the Chinese Population: Exclusion of Ineligible Candidates for Adjuvant Chemotherapy
Fang, Dong1; Zhang, Qifu2; Li, Xuesong1; Qian, Cheng1; Xiong, Gengyan1; Zhang, Lei1; Chen, Xiaopeng1,3; Zhang, Xiaoyu1; Yu, Wei1; He, Zhisong1; Zhou, Liqun1
刊名BIOMED RESEARCH INTERNATIONAL
2014
DOI10.1155/2014/529186
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]UPPER URINARY-TRACT ; TRANSITIONAL-CELL-CARCINOMA ; GLOMERULAR-FILTRATION-RATE ; CHRONIC KIDNEY-DISEASE ; PREOPERATIVE HYDRONEPHROSIS ; RADICAL NEPHROURETERECTOMY ; BLADDER-CANCER ; OUTCOMES ; RECURRENCE ; EXPERIENCE
英文摘要

Objectives. To report the decline of renal function after radical nephroureterectomy (RNU) in upper tract urothelial carcinoma (UTUC) patients and to develop a nomogram to predict ineligibility for cisplatin-based adjuvant chemotherapy (AC). Methods. We retrospectively analyzed 606 consecutive Chinese UTUC patients treated by RNU from 2000 to 2010. We chose an eGFR of 60 and 45 ml/min/1.73 m(2) as cut-offs for full-dose and reduced-dose AC eligibility. Results. Median eGFR for all patients before and after surgery was 64 and 49 ml/min/1.73 m(2) (P < 0.001). The proportion of patients ineligible to receive full-dose and reduced-dose AC changed from 42% to 74% and from 20% to 38.1%. Older age (OR = 1.007), preoperative eGFR (OR = 0.993), absence of hydronephrosis (OR = 0.801), smaller tumor size (OR = 0.962), and tumor without multifocality (OR = 0.876) were predictive for ineligibility for full-dose AC. Preoperative eGFR (OR = 0.991), absence of hydronephrosis (OR = 0.881), tumor located in renal pelvis (OR = 1.164), and smaller tumor size (OR = 0.969) could predict ineligibility for reduced-dose AC. The c-index of the two models was 0.757 and 0.836. Postoperative renal function was not associated with worse survival. Conclusions. Older age, lower preoperative eGFR, smaller tumor size, tumor located in renal pelvis, and absence of hydronephrosis or multifocality were predictors of postoperative renal insufficiency.

语种英语
WOS记录号WOS:000340764200001
项目编号BMU20120318 ; 7122183 ; 81172419 ; 81372746
资助机构Collaborative Research Foundation of Peking University Health Science Center ; National Taiwan University, College of Medicine ; Natural Science Foundation of Beijing ; Natural Science Foundation of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64628
专题北京大学第一临床医学院_泌尿外科
北京大学口腔医学院_中心实验室
作者单位1.Peking Univ, Hosp 1, Inst Urol, Dept Urol,Natl Urol Canc Ctr, Beijing 100034, Peoples R China
2.Jilin Tumour Hosp, Dept Urol, Changchun 130021, Jilin, Peoples R China
3.Fourth Mil Med Univ, Tangdu Hosp, Dept Urol, Xian 710038, Shaanxi, Peoples R China
推荐引用方式
GB/T 7714
Fang, Dong,Zhang, Qifu,Li, Xuesong,et al. Nomogram Predicting Renal Insufficiency after Nephroureterectomy for Upper Tract Urothelial Carcinoma in the Chinese Population: Exclusion of Ineligible Candidates for Adjuvant Chemotherapy[J]. BIOMED RESEARCH INTERNATIONAL,2014.
APA Fang, Dong.,Zhang, Qifu.,Li, Xuesong.,Qian, Cheng.,Xiong, Gengyan.,...&Zhou, Liqun.(2014).Nomogram Predicting Renal Insufficiency after Nephroureterectomy for Upper Tract Urothelial Carcinoma in the Chinese Population: Exclusion of Ineligible Candidates for Adjuvant Chemotherapy.BIOMED RESEARCH INTERNATIONAL.
MLA Fang, Dong,et al."Nomogram Predicting Renal Insufficiency after Nephroureterectomy for Upper Tract Urothelial Carcinoma in the Chinese Population: Exclusion of Ineligible Candidates for Adjuvant Chemotherapy".BIOMED RESEARCH INTERNATIONAL (2014).
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