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学科主题: 临床医学
题名:
Nomogram Predicting Renal Insufficiency after Nephroureterectomy for Upper Tract Urothelial Carcinoma in the Chinese Population: Exclusion of Ineligible Candidates for Adjuvant Chemotherapy
作者: Fang, Dong1; Zhang, Qifu2; Li, Xuesong1; Qian, Cheng1; Xiong, Gengyan1; Zhang, Lei1; Chen, Xiaopeng1,3; Zhang, Xiaoyu1; Yu, Wei1; He, Zhisong1; Zhou, Liqun1
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2014
DOI: 10.1155/2014/529186
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: UPPER URINARY-TRACT ; TRANSITIONAL-CELL-CARCINOMA ; GLOMERULAR-FILTRATION-RATE ; CHRONIC KIDNEY-DISEASE ; PREOPERATIVE HYDRONEPHROSIS ; RADICAL NEPHROURETERECTOMY ; BLADDER-CANCER ; OUTCOMES ; RECURRENCE ; EXPERIENCE
英文摘要:

Objectives. To report the decline of renal function after radical nephroureterectomy (RNU) in upper tract urothelial carcinoma (UTUC) patients and to develop a nomogram to predict ineligibility for cisplatin-based adjuvant chemotherapy (AC). Methods. We retrospectively analyzed 606 consecutive Chinese UTUC patients treated by RNU from 2000 to 2010. We chose an eGFR of 60 and 45 ml/min/1.73 m(2) as cut-offs for full-dose and reduced-dose AC eligibility. Results. Median eGFR for all patients before and after surgery was 64 and 49 ml/min/1.73 m(2) (P < 0.001). The proportion of patients ineligible to receive full-dose and reduced-dose AC changed from 42% to 74% and from 20% to 38.1%. Older age (OR = 1.007), preoperative eGFR (OR = 0.993), absence of hydronephrosis (OR = 0.801), smaller tumor size (OR = 0.962), and tumor without multifocality (OR = 0.876) were predictive for ineligibility for full-dose AC. Preoperative eGFR (OR = 0.991), absence of hydronephrosis (OR = 0.881), tumor located in renal pelvis (OR = 1.164), and smaller tumor size (OR = 0.969) could predict ineligibility for reduced-dose AC. The c-index of the two models was 0.757 and 0.836. Postoperative renal function was not associated with worse survival. Conclusions. Older age, lower preoperative eGFR, smaller tumor size, tumor located in renal pelvis, and absence of hydronephrosis or multifocality were predictors of postoperative renal insufficiency.

语种: 英语
所属项目编号: BMU20120318 ; 7122183 ; 81172419 ; 81372746
项目资助者: Collaborative Research Foundation of Peking University Health Science Center ; National Taiwan University, College of Medicine ; Natural Science Foundation of Beijing ; Natural Science Foundation of China
WOS记录号: WOS:000340764200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64628
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Inst Urol, Dept Urol,Natl Urol Canc Ctr, Beijing 100034, Peoples R China
2.Jilin Tumour Hosp, Dept Urol, Changchun 130021, Jilin, Peoples R China
3.Fourth Mil Med Univ, Tangdu Hosp, Dept Urol, Xian 710038, Shaanxi, Peoples R China

Recommended Citation:
Fang, Dong,Zhang, Qifu,Li, Xuesong,et al. Nomogram Predicting Renal Insufficiency after Nephroureterectomy for Upper Tract Urothelial Carcinoma in the Chinese Population: Exclusion of Ineligible Candidates for Adjuvant Chemotherapy[J]. BIOMED RESEARCH INTERNATIONAL,2014.
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