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学科主题: 基础医学
题名:
Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells
作者: Yang, Haixia1,2,3; Xiao, Lei1; Yuan, Yue1; Luo, Xiaoqin1,2; Jiang, Manli1; Ni, Jiahua1; Wang, Nanping1,4
关键词: Procyanidin B2 ; NLRP3 inflammasome ; ROS ; AP-1
刊名: BIOCHEMICAL PHARMACOLOGY
发表日期: 2014-12-15
DOI: 10.1016/j.bcp.2014.10.001
卷: 92, 期:4, 页:599-606
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ADENOVIRUS-MEDIATED OVEREXPRESSION ; INTERCELLULAR-ADHESION MOLECULE-1 ; NF-KAPPA-B ; C-JUN ; RECEPTOR-GAMMA ; MACROPHAGES ; EXPRESSION ; TLR4 ; PROTEIN-1 ; INDUCTION
英文摘要:

Procyanidins are the flavanols from polyphenols commonly found in fruits and red wine. Recent studies have shown that procyanidins possess potential anti-inflammatory activities. However, underlying mechanisms remain to be understood. Inflammasomes are multi-protein complexes composed of pro-caspase and pattern recognition receptors (PRRs) such as NOD-like receptor family, pyrin domain containing 3 (NLRP3). Since aberrant activation of NLRP3 intlammasome is implicated in the pathogeneses of pro-inflammatory diseases such as diabetes, atherosclerosis and arthritis, we aimed to investigate whether procyanidin B2 (PCB2), the most widely distributed natural procyanidins, inhibits the activation of NLRP3 inflammasome in endothelial cells (ECs). We found that, in human umbilical vein ECs (HUVECs), PCB2 significantly suppressed the activation of NLRP3 inflammasome and inhibited subsequent caspase-1 activation and interleukin (IL)-1 beta secretion in response to lipopolysaccharides (LPS). PCB2 negatively regulated the gene expression of NLRP3. In addition, PCB2 attenuated LPS-induced production of reactive oxygen species (ROS) and the transcriptional activity of activator protein-1 (AP-1). In conclusion, we demonstrated for the first time that procyanidin B2 inhibits NLRP3 inflammasome activation via suppression of AP-1 pathway in ECs. These results suggest a new mechanism by which natural flavoids such as procyanidins exert their vascular protective effects. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 31430045 ; 81470373 ; 21306146 ; 81220108005 ; 81300242 ; 2014T70926
项目资助者: National Natural Science Foundation of China ; China Postdoctoral Science Foundation
WOS记录号: WOS:000346889100008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64631
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Xi An Jiao Tong Univ, Cardiovasc Res Ctr, Xian 710061, Peoples R China
2.Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, Xian 710061, Peoples R China
3.Nutr & Food Safety Engn Res Ctr Shaanxi Prov, Xian 710061, Peoples R China
4.Peking Univ, Inst Cardiovasc Sci, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Haixia,Xiao, Lei,Yuan, Yue,et al. Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells[J]. BIOCHEMICAL PHARMACOLOGY,2014,92(4):599-606.
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