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学科主题: 临床医学
题名:
Taurine inhibits ischemia/reperfusioni-induced compartment syndrome in rabbits
作者: Wang, JX; Li, Y; Zhang, LK; Zhao, J; Pang, YZ; Tang, CS; Zhang, J
关键词: taurine ; compartment syndromes ; reperfusion injury
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2005-07-01
DOI: 10.1111/j.1745-7254.2005.00128.x
卷: 26, 期:7, 页:821-827
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: ISCHEMIA-REPERFUSION INJURY ; LIPID-PEROXIDATION ; RAT ; ENZYMES ; MUSCLE
英文摘要:

Aim: To investigate effects of taurine on ischemia/reperfusion (I/R)-induced compartment syndrome in rabbit hind limbs. Methods: Rabbits underwent femoral artery occlusion after ligation of branches from terminal aorta to femoral artery. After a 7-h ischemia, reperfusion was established with the use of heparinized polyethylene shunts. Rabbits received taurine (1 g/kg) or normal saline (control) by iv infusion 10 min before shunt placement. During reperfusion, anterior compartment pressure (ACP) was monitored continuously in the left lower extremity. Gastrocnemius muscle triphenyltetrazolium chloride (TTC) level, taurine content and myeloperoxidase activity were assayed. Oxidative stress was induced in the in vitro gastrocnemius muscle slices by free radical generating systems (FRGS), and the malondialdehyde content was measured in presence or absence of taurine. Results: After 7 h of ischemia, none of the parameters that we measured were different from those before ischemia, except that TTC reduction decreased by 80%. In the control group, after 2 h of reperfusion, ACP increased 4.5-fold, and gastrocnemius muscle taurine content was reduced by 33%. In taurine-treated animals, at 2 h reperfusion, the mean arterial blood pressure and heart rate were increased, by 6% and 10%. ACP decreased by 39%, muscle edema decreased by 16%, TTC reduction increased by 150%, and lactate dehydrogenase decreased by 36% compared to control group. Plasma and muscle taurine content increased by 70% and 88%, respectively. In the taurine-treated group, at 2 h reperfusion, plasma malondialdehyde and conjugated diene content were decreased by 38% and 23%, respectively, and muscle malondialdehyde and conjugated diene content decreased by 22% and 30%, respectively compared to the control group. At 2 h reperfusion, myeloperoxidase activity was increased 3.5-fold in control animals. In the in vitro study, taurine decreased malondialdehyde content in muscle slices incubated with hypochlorous acid in a dose-dependent manner, but there was no change when incubated with hydrogen peroxide and xanthine oxidase. Conclusion: Treatment with taurine inhibited I/R-induced compartment syndrome by at least in part attenuating oxidative stress injury induced by I/R, suggesting clinical application of taurine might be a new strategy for the prevention and treatment of compartment syndrome.

语种: 英语
WOS记录号: WOS:000230442400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64634
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 1, Inst Cardiovasc Dis Res, Beijing 100034, Peoples R China
3.Capital Inst Med, Dept Pathophysiol, Beijing 100054, Peoples R China
4.Peking Univ, Hlth Ctr Med Sci, Dept Physiol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, JX,Li, Y,Zhang, LK,et al. Taurine inhibits ischemia/reperfusioni-induced compartment syndrome in rabbits[J]. ACTA PHARMACOLOGICA SINICA,2005,26(7):821-827.
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