IR@PKUHSC  > 北京大学临床肿瘤学院  > 流行病学研究室
学科主题临床医学
Methylation Status of Blood Leukocyte DNA and Risk of Gastric Cancer in a High-Risk Chinese Population
Zhang, Yang1; Su, Hui-juan1; Pan, Kai-feng1; Zhang, Lian1; Ma, Jun-ling1; Shen, Lin2; Li, Ji-you3; Liu, Wei-dong4; Oze, Isao5; Matsuo, Keitaro5; Yuasa, Yasuhito6; You, Wei-cheng1
刊名CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
2014-10-01
DOI10.1158/1055-9965.EPI-13-0994
23期:10页:2019-2026
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]Oncology ; Public, Environmental & Occupational Health
关键词[WOS]CPG ISLAND METHYLATION ; HELICOBACTER-PYLORI INFECTION ; BECKWITH-WIEDEMANN-SYNDROME ; PROMOTER METHYLATION ; COLORECTAL-CANCER ; IGF2 EXPRESSION ; DIETARY FACTORS ; LESIONS ; GROWTH ; GENE
英文摘要

Background: To evaluate the relationship between methylation status of blood leukocyte DNA and risk of gastric cancer, a population-based study was conducted in Linqu County.

Methods: Methylation levels of IGFII and N33 were determined by quantitative methylation-specific PCR. The temporal trend of methylation levels during gastric cancer development was investigated in 133 gastric cancer cases from two cohorts with pre- and/or post-gastric cancer samples. As the references of pre-GCs, 204 intestinal metaplasia (IM) or dysplasia (DYS) subjects who did not progress to gastric cancer during the follow-up period were selected. Meanwhile, 285 subjects with superficial gastritis/chronic atrophic gastritis (SG/CAG) were also selected as controls.

Results: IGFII median methylation level was significantly higher in gastric cancer cases than those with SG/CAG (61.47% vs. 49.73%; P < 0.001). IGFII and N33 methylation levels were elevated at least 5 years ahead of clinical gastric cancer diagnosis comparing with SG/CAG (63.38% vs. 49.73% for IGFII, 9.12% vs. 5.70% for N33; all P < 0.001). Furthermore, the frequency of hypermethylated IGFII was markedly increased in IM or DYS subjects who progressed to gastric cancer in contrast to those who remained with IM and DYS, and adjusted ORs were 12.52 [95% confidence interval (CI), 3.81-41.15] for IM and 10.12 (95% CI, 2.68-38.22) for DYS. Similar results were also found for N33 in subjects with IM (OR, 3.77; 95% CI, 1.20-11.86).

Conclusions: Our findings suggested that hypermethylated IGFII and N33 in blood leukocyte DNA were associated with risk of gastric cancer in a Chinese population.

Impact: IGFII and N33 methylation status may be related to gastric carcinogenesis. (C) 2014 AACR.

语种英语
WOS记录号WOS:000345277400007
项目编号30921140311 ; 81171989 ; 30801346 ; 2010CB529303
资助机构A3 Foresight Program from Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program)
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64640
专题北京大学临床肿瘤学院_流行病学研究室
作者单位1.Hlth Bur Linqu Cty, Linqu, Shandong, Peoples R China
2.Tokyo Med & Dent Univ, Dept Mol Oncol, Tokyo, Japan
3.Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Dept Canc Epidemiol, Beijing 100142, Peoples R China
4.Peking Univ Canc Hosp & Inst, Dept Gastrointestinal Oncol, Beijing 100142, Peoples R China
5.Peking Univ Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
6.Aichi Canc Ctr, Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, Japan
推荐引用方式
GB/T 7714
Zhang, Yang,Su, Hui-juan,Pan, Kai-feng,et al. Methylation Status of Blood Leukocyte DNA and Risk of Gastric Cancer in a High-Risk Chinese Population[J]. CANCER EPIDEMIOLOGY BIOMARKERS &amp; PREVENTION,2014,23(10):2019-2026.
APA Zhang, Yang.,Su, Hui-juan.,Pan, Kai-feng.,Zhang, Lian.,Ma, Jun-ling.,...&You, Wei-cheng.(2014).Methylation Status of Blood Leukocyte DNA and Risk of Gastric Cancer in a High-Risk Chinese Population.CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,23(10),2019-2026.
MLA Zhang, Yang,et al."Methylation Status of Blood Leukocyte DNA and Risk of Gastric Cancer in a High-Risk Chinese Population".CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 23.10(2014):2019-2026.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Yang]的文章
[Su, Hui-juan]的文章
[Pan, Kai-feng]的文章
百度学术
百度学术中相似的文章
[Zhang, Yang]的文章
[Su, Hui-juan]的文章
[Pan, Kai-feng]的文章
必应学术
必应学术中相似的文章
[Zhang, Yang]的文章
[Su, Hui-juan]的文章
[Pan, Kai-feng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。