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PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users
Shi, Jie1; Zhao, Li-Yan1; Copersino, Marc L.2; Fang, Yu-Xia3; Chen, Yingmao; Tian, Aahe; Deng, Yanping1,4; Shuai, Yinhang4,5; Jin, Jun5; Lu, Lin1
关键词heroin abuse craving anxiety prolonged withdrawal dopamine transporter positron emission tomography methadone maintenance treatment
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2008-01-28
DOI10.1016/j.ejphar.2007.09.042
579期:1-3页:160-166
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]OPIATE-DEPENDENT SUBJECTS ; OPIOID ADDICTION ; LONG-TERM ; COCAINE ; STRESS ; SPECT ; AMPHETAMINE ; TOMOGRAPHY ; WITHDRAWAL ; MECHANISM
英文摘要

It has been documented that methadone maintenance treatment is effective in reducing drug craving and relevant risk behaviors in heroin users. However, it is not understood whether methadone maintenance treatment impairs the dopamine transporter in the striatum. To establish whether chronic opiate use might impair brain dopamine neurons in humans, we assessed dopamine transporter (DAT) uptake function in the striatum (caudate and putamen), and analyzed the correlation between DAT in the striatum and heroin craving and subjective anxiety in former heroin users with prolonged abstinence and in patients receiving methadone maintenance treatment. Binding of [C-11]-2 beta-carbomethoxy-3 beta-aryltropane ([C-11] CFT) as a brain dopamine transporter ligand was measured with positron emission tomography (PET) in eleven former heroin users with prolonged abstinence, ten patients receiving methadone maintenance treatment and ten healthy control subjects. Heroin craving and subjective anxiety in prolonged abstinence and methadone maintenance treatment groups were assessed and the correlations between DAT of striatum and heroin craving or subjective anxiety were determined. In comparison with healthy control subjects, methadone maintenance treatment subjects had lower DAT uptake function in the bilateral caudate and putamen and prolonged abstinence subjects showed significantly lower DAT uptake function in the bilateral caudate. Moreover, in comparison to the prolonged abstinence subjects, the methadone maintenance treatment subjects showed significant decreases of DAT uptake in the bilateral putamen. DAT uptake function in bilateral striatum was not associated with heroin craving in prolonged abstinence or in methadone maintenance treatment subjects; however, DAT uptake function in the bilateral caudate was significantly correlated with subjective anxiety in methadone maintenance treatment subjects. Our findings suggest that chronic opioid use induces long-lasting striatum dopamine neuron impairment, and prolonged withdrawal from opioids can benefit the recovery of impaired dopamine neurons in the brain. (C) 2007 Elsevier B.V All rights reserved.

语种英语
WOS记录号WOS:000252979200021
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64643
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
2.Harvard Univ, Sch Med, McLean Hosp, Alcohol & Drug Abuse Treatment Program, Belmont, MA 02478 USA
3.NIH, Intramural Res Program, Natl Inst Drug Abuse, Baltimore, MD 21224 USA
4.China PLA Gen Hosp, Beijing 100062, Peoples R China
5.Beijing Ankang Hosp, Beijing 102406, Peoples R China
推荐引用方式
GB/T 7714
Shi, Jie,Zhao, Li-Yan,Copersino, Marc L.,et al. PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2008,579(1-3):160-166.
APA Shi, Jie.,Zhao, Li-Yan.,Copersino, Marc L..,Fang, Yu-Xia.,Chen, Yingmao.,...&Lu, Lin.(2008).PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users.EUROPEAN JOURNAL OF PHARMACOLOGY,579(1-3),160-166.
MLA Shi, Jie,et al."PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users".EUROPEAN JOURNAL OF PHARMACOLOGY 579.1-3(2008):160-166.
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