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学科主题: 临床医学
题名:
Treatment Patterns and Glycemic Control in Older Adults with Type 2 Diabetes Mellitus Receiving Only Oral Antidiabetes Drugs in China
作者: Zhang, Lihua1; Ji, Linong1; Guo, Lixin2; Lu, Juming3; Tian, Haoming4; Zhu, Dalong5; Xing, Xiaoping6; Weng, Jian Ping7; Jia, Weiping8; China Type 2 Diabetes Treatment St
刊名: DIABETES TECHNOLOGY & THERAPEUTICS
发表日期: 2015-11-01
DOI: 10.1089/dia.2015.0094
卷: 17, 期:11, 页:816-824
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: INSULIN-SECRETION ; PREVALENCE ; MANAGEMENT ; TRANSITION ; NUTRITION ; HEALTH
英文摘要:

Background: Only a few studies have reported the use of oral antidiabetes drugs (OADs) for treating older adults with type 2 diabetes mellitus (T2DM) in China. This study assessed the status of OAD therapy and relevant factors associated with OAD treatment patterns and glycemic control among older patients. Patients and Methods: We conducted a noninterventional, observational, cross-sectional, multicenter study, which was initiated by the Chinese Diabetes Society, in which 9,872 outpatients with T2DM were recruited who received OADs only. Current antidiabetes treatment regimens and related clinical data were collected from patients′ self-reporting and medical records. Participants were divided into two groups: 65 years and <65 years. All data were tabulated, and statistical analyses were performed using SPSS version 16 software (SPSS Inc., Chicago, IL). Results: Insulin secretagogues (52.6%): sulfonylureas (SU) (26.6%) and glinides (26.0%) were commonly used as monotherapy in those 65 years. The most popular OAD pattern was dual combination therapy (46.8%), with SU plus glucosidase inhibitors (25.1%) being most common in older participants. Age, diabetes duration, body mass index, achieving the glycemic control targets, and hypoglycemia were influencing factors to those 65 years in diverse treatment pattern models (P<0.05). Older patients receiving OADs with triple or more combination treatment and complications were more likely to have substandard glycemic control (hemoglobin A1c level 7%). Conclusions: The pattern of OADs alone in older adults with T2DM was significantly different from those <65 years in China. A comprehensive OAD treatment pattern or insulin combination may be necessary for better glycemic control in older patients with multiple combinations of OADs or complications.

语种: 英语
项目资助者: Novartis Pharma Co. Ltd., Beijing, China
WOS记录号: WOS:000364229300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64644
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Beijing Hosp, Dept Endocrinol & Metab, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100853, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol & Metab, Beijing, Peoples R China
4.Sichuan Univ, Dept Endocrinol & Metab, West China Hosp, Chengdu 610064, Peoples R China
5.Nanjing Drum Tower Hosp, Dept Endocrinol & Metab, Nanjing, Jiangsu, Peoples R China
6.Beijing Union Med Coll Hosp, Dept Endocrinol & Metab, Beijing, Peoples R China
7.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Endocrinol & Metab, Guangzhou 510275, Guangdong, Peoples R China
8.Shanghai Jiao Tong Univ, Dept Endocrinol & Metab, Affiliated Peoples Hosp 6, Shanghai 200030, Peoples R China

Recommended Citation:
Zhang, Lihua,Ji, Linong,Guo, Lixin,et al. Treatment Patterns and Glycemic Control in Older Adults with Type 2 Diabetes Mellitus Receiving Only Oral Antidiabetes Drugs in China[J]. DIABETES TECHNOLOGY &amp; THERAPEUTICS,2015,17(11):816-824.
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