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Dysfunctional connectivity patterns in chronic heroin users: An fMRI study
Liu, Jixin1; Liang, Jimin1; Qin, Wei1; Tian, Jie1,2; Yuan, Kai1; Bai, Lijun1; Zhang, Yi1; Wang, Wei3; Wang, Yarong3; Li, Qiang3; Zhao, Liyan4; Lu, Lin4; von Deneen, Karen M.5,6; Liu, Yijun5,6; Gold, Mark S.5,6
关键词fMRI Chronic heroin user Graph theory analysis Resting state
刊名NEUROSCIENCE LETTERS
2009-08-21
DOI10.1016/j.neulet.2009.05.038
460期:1页:72-77
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NEUROIMAGING EVIDENCE ; DRUG-ADDICTION ; HUMAN BRAIN ; STRESS ; INTEGRATION ; NETWORKS ; RELAPSE ; CORTEX ; NEUROBIOLOGY ; ASSOCIATION
英文摘要

Recent functional neuroimaging studies have examined cognitive inhibitory control, decision-making and stress regulation in heroin addiction using a cue-reactivity paradigm. Few studies have considered impairments in heroin users from an integrated perspective for evaluation of their brain functions. We hypothesized that the brain regions that are dysregulated in the chronic heroin users during cue-reactivity studies may also show dysfunctional connectivity in memory, inhibition and motivation-related dysfunctions during a resting state free of cues. The present study used resting functional magnetic resonance imaging (fMRI) to compare the interaction of brain regions between 12 chronic heroin users and 12 controls by employing a novel graph theory analysis (GTA) method. As a data-driven approach, GTA has the advantage of evaluating the strength as well as the temporal and spatial patterns of interactions among the brain regions. Abnormal topological properties were explored in the brain of chronic heroin users, such as the dysfunctional connectivity in the prefrontal cortex, ACC, SMA, ventral striatum, insula, amygdala and hippocampus. Our results suggest that GTA is a useful tool in defining dysregulated neural networks even during rest. This dysfunctional brain connectivity may contribute to decrease self-control, impaired inhibitory function as well deficits in stress regulation in chronic heroin users. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000267633400015
项目编号IRT0645 ; 30528027 ; 30873462 ; 90209008 ; 30870685 ; 30672690 ; 30600151 ; 60532050 ; 60621001 ; 4071003 ; 2006CB705700 ; 2008AA01Z411
资助机构Changjiang Scholars and Innovative Research Team in University (PCSIRT) ; Ministry of Education of China ; Research Fund for Overseas Chinese Young Scholars ; National Natural Science Foundation of China ; Beijing Natural Science Fund ; Project for the National Key Basic Research and Development Program ; 863 program
引用统计
被引频次:72[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64648
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.Xidian Univ, Sch Elect Engn, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
3.Fourth Mil Med Univ, Xian 710038, Shaanxi, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
5.Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL 32610 USA
6.Univ Florida, McKnight Brain Inst, Dept Neurosci, Gainesville, FL 32610 USA
推荐引用方式
GB/T 7714
Liu, Jixin,Liang, Jimin,Qin, Wei,et al. Dysfunctional connectivity patterns in chronic heroin users: An fMRI study[J]. NEUROSCIENCE LETTERS,2009,460(1):72-77.
APA Liu, Jixin.,Liang, Jimin.,Qin, Wei.,Tian, Jie.,Yuan, Kai.,...&Gold, Mark S..(2009).Dysfunctional connectivity patterns in chronic heroin users: An fMRI study.NEUROSCIENCE LETTERS,460(1),72-77.
MLA Liu, Jixin,et al."Dysfunctional connectivity patterns in chronic heroin users: An fMRI study".NEUROSCIENCE LETTERS 460.1(2009):72-77.
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