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学科主题: 临床医学
题名:
Current opinion on use of luteinizing hormone supplementation in assisted reproduction therapy: an Asian perspective
作者: Wong, Peng Cheang1; Qiao, Jie2; Ho, Clement3; Ramaraju, Gottumukkala A.4; Wiweko, Budi5; Takehara, Yuji6; Nadkarni, Prashant V.7; Cheng, Li-Chang8; Chen, Hsin-Fu9; Suwajanakorn, Somchai10; Thi Ngoc Lan Vuong11; Asia Pacific Fertility Advisory
关键词: Asia ; GnRH agonist ; IVF ; ovarian stimulation ; recombinant LH
刊名: REPRODUCTIVE BIOMEDICINE ONLINE
发表日期: 2011-07-01
DOI: 10.1016/j.rbmo.2011.03.023
卷: 23, 期:1, 页:81-90
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: FOLLICLE-STIMULATING-HORMONE ; IN-VITRO FERTILIZATION ; RECOMBINANT HUMAN LH ; CONTROLLED OVARIAN HYPERSTIMULATION ; AGONIST DOWN-REGULATION ; NORMOGONADOTROPHIC WOMEN ; SUBOPTIMAL RESPONSE ; ANOVULATORY WOMEN ; LONG PROTOCOL ; LIVE BIRTH
英文摘要:

LH and FSH have complementary functions in ensuring optimal oocyte maturation and ovulation. In women undergoing assisted reproduction technology protocols with gonadotrophin-releasing hormone analogues, LH and FSH concentrations are reduced. While FSH use in assisted reproduction technology is well established, there is no published consensus on the need for exogenous LH in Asian patients. Having reviewed the concept of the LH therapeutic window and differences between recombinant human LH (r-HLH) and human menopausal gonadotrophin, a consensus was reached on which patient subgroups may benefit from LH supplementation. Adjuvant r-HLH gives clinicians precise control over the dose of LH bioactivity administered to target the therapeutic window. The use of r-HLH is recommended in women with poor response in a previous cycle or suboptimal follicular progression in a current cycle by day 6-8 of stimulation. r-HLH should also be considered in women at risk of suboptimal response, LH and anti-Mullerian hormone concentrations, antral follicle count and LH polymorphisms require further research and verification. For measurement of LH response adequacy, the monitoring of follicular progression, oestradiol concentrations and endometrial thickness is recommended. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

语种: 英语
项目资助者: Merck Serono
WOS记录号: WOS:000303044300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64653
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Thomson Med Ctr, Thomson Fertil Ctr, Singapore, Singapore
2.Natl Univ Singapore Hosp, Dept Obstet & Gynaecol, Singapore 117548, Singapore
3.Peking Univ, Hosp 3, Reprod Med Ctr, Beijing 100871, Peoples R China
4.Assisted Reprod Technol ART Lab, Hong Kong, Hong Kong, Peoples R China
5.Krishna IVF Clin, Visakhapatnam, Andhra Pradesh, India
6.Kato Ladies Clin, Adv Med Res Inst Fertil, Tokyo, Japan
7.KL Fertil & Gynaecol Ctr, Kuala Lumpur, Malaysia
8.Univ Indonesia, Dr Cipto Mangunkusumo Gen Hosp, Fac Med, Dept Obstet & Gynecol, Jakarta, Indonesia
9.Natl Taiwan Univ Hosp, Dept Obstet Gynecol, Taipei, Taiwan
10.Chulalongkorn Univ, Fac Med, Dept Obstet & Gynecol, Bangkok 10330, Thailand
11.Univ Med & Pharm, Dept Obstet & Gynaecol, Ho Chi Minh City, Vietnam

Recommended Citation:
Wong, Peng Cheang,Qiao, Jie,Ho, Clement,et al. Current opinion on use of luteinizing hormone supplementation in assisted reproduction therapy: an Asian perspective[J]. REPRODUCTIVE BIOMEDICINE ONLINE,2011,23(1):81-90.
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