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学科主题: 基础医学
题名:
Human HS1BP3 induces cell apoptosis and activates AP-1
作者: Shi, Taiping1,2,3; Xie, Jieshi3; Xiong, Ying3; Deng, Weiwei3; Guo, Jinhai3; Wang, Feng3; Ma, Dalong1,2,3
关键词: AP-1 ; Apoptosis ; HS1 ; HS1BP3
刊名: BMB REPORTS
发表日期: 2011-06-30
DOI: 10.5483/BMBRep.2011.44.6.381
卷: 44, 期:6, 页:381-386
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: C-JUN ; MEDIATED APOPTOSIS ; PARKINSON-DISEASE ; ESSENTIAL TREMOR ; PROTEIN ; VARIANT ; KINASE ; DEATH ; GENE ; REQUIREMENT
英文摘要:

In the present study, we characterized the function of HS1-binding protein 3 (HS1BP3), which is mutated in essential tremor and may be involved in lymphocyte activation. We found that HS1BP3 localized to the mitochondria and endoplasmic reticulum partially. Overexpression of HS1BP3 induced apoptosis in HEK293T and HeLa cell lines. When these cell lines were transfected with HS1BP3, they exhibited nuclear DNA condensation, externalization of phosphatidylserine (PS), and cleavage of poly ADP ribose polymerase (PARP). Furthermore, suppression of HS1BP3 or HS1 expression attenuates HS1BP3 induced apoptosis. In addition, HS1BP3 enhanced activator protein 1 (AP-1)-mediated transcription in a dose-dependent manner. Therefore, we conclude that HS1BP3 regulates apoptosis via HS1 and stimulates AP-1-mediated transcription. [BMB reports 2011; 44(6): 381-386]

语种: 英语
所属项目编号: 2006AA02A305 ; 2009ZX09503-004
项目资助者: National High Technology Research and Development Program (863 Program) of China ; Key National S& ; T Program-"Major New Drug Development"
WOS记录号: WOS:000292223500004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64662
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Chinese Natl Human Genome Ctr, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100871, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100871, Peoples R China

Recommended Citation:
Shi, Taiping,Xie, Jieshi,Xiong, Ying,et al. Human HS1BP3 induces cell apoptosis and activates AP-1[J]. BMB REPORTS,2011,44(6):381-386.
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