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HPLC determination of four active saponins from Panax notoginseng in rat serum and its application to pharmacokinetic studies
Li, L; Sheng, YX; Zhang, JL; Wang, CS; Guo, D
关键词ginsenosides notoginsenoside Panax notoginseng rat serum HPLC pharmacokinetics
刊名BIOMEDICAL CHROMATOGRAPHY
2004-12-01
DOI10.1002/bmc.400
18期:10页:849-856
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]GINSENG SAPONINS ; METABOLISM ; ABSORPTION ; EXCRETION ; RG1
英文摘要

Four main active saponins (ginsenosides Rg(1), Rb-1, Rd and notoginsenoside R-1) in Panax notoginseng in rat serum after oral and intravenous administration of total saponins of P. notoginseng (PNS) to rats were determined using a simple and sensitive high-performance chromatographic method. The serum samples were pretreated with solid-phase extraction before analysis. The calibration curves for the four saponins were linear in the given concentration ranges. The intra-day and inter-day assay coefficients in serum were less than 10.0% and the recoveries of the method were higher than 80.0% in the high, middle and low concentrations. This method was applied to study the pharmacokinetics following oral and intravenous administration of PNS. Copyright (C) 2004 John Wiley Sons, Ltd.

语种英语
WOS记录号WOS:000226044900012
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64663
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Li, L,Sheng, YX,Zhang, JL,et al. HPLC determination of four active saponins from Panax notoginseng in rat serum and its application to pharmacokinetic studies[J]. BIOMEDICAL CHROMATOGRAPHY,2004,18(10):849-856.
APA Li, L,Sheng, YX,Zhang, JL,Wang, CS,&Guo, D.(2004).HPLC determination of four active saponins from Panax notoginseng in rat serum and its application to pharmacokinetic studies.BIOMEDICAL CHROMATOGRAPHY,18(10),849-856.
MLA Li, L,et al."HPLC determination of four active saponins from Panax notoginseng in rat serum and its application to pharmacokinetic studies".BIOMEDICAL CHROMATOGRAPHY 18.10(2004):849-856.
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