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学科主题: 药学
题名:
HPLC determination of four active saponins from Panax notoginseng in rat serum and its application to pharmacokinetic studies
作者: Li, L; Sheng, YX; Zhang, JL; Wang, CS; Guo, D
关键词: ginsenosides ; notoginsenoside ; Panax notoginseng ; rat serum ; HPLC ; pharmacokinetics
刊名: BIOMEDICAL CHROMATOGRAPHY
发表日期: 2004-12-01
DOI: 10.1002/bmc.400
卷: 18, 期:10, 页:849-856
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: GINSENG SAPONINS ; METABOLISM ; ABSORPTION ; EXCRETION ; RG1
英文摘要:

Four main active saponins (ginsenosides Rg(1), Rb-1, Rd and notoginsenoside R-1) in Panax notoginseng in rat serum after oral and intravenous administration of total saponins of P. notoginseng (PNS) to rats were determined using a simple and sensitive high-performance chromatographic method. The serum samples were pretreated with solid-phase extraction before analysis. The calibration curves for the four saponins were linear in the given concentration ranges. The intra-day and inter-day assay coefficients in serum were less than 10.0% and the recoveries of the method were higher than 80.0% in the high, middle and low concentrations. This method was applied to study the pharmacokinetics following oral and intravenous administration of PNS. Copyright (C) 2004 John Wiley Sons, Ltd.

语种: 英语
WOS记录号: WOS:000226044900012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64663
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China

Recommended Citation:
Li, L,Sheng, YX,Zhang, JL,et al. HPLC determination of four active saponins from Panax notoginseng in rat serum and its application to pharmacokinetic studies[J]. BIOMEDICAL CHROMATOGRAPHY,2004,18(10):849-856.
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