|Cytokine levels in crevicular fluid are less responsive to orthodontic force in adults than in juveniles|
|Ren, YJ; Maltha, JC; van′ t Hof, MA; Von den Hoff, JW; Kuijpers-Jagtman, AM; Zhang, D|
|关键词||adults cytokines GCF juveniles tooth movement|
|刊名||JOURNAL OF CLINICAL PERIODONTOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Dentistry, Oral Surgery & Medicine|
|研究领域[WOS]||Dentistry, Oral Surgery & Medicine|
|关键词[WOS]||PERIODONTAL-LIGAMENT FIBROBLASTS ; NECROSIS-FACTOR-ALPHA ; PROSTAGLANDIN-E ; TOOTH MOVEMENT ; RATS ; AGE ; INTERLEUKIN-1-BETA ; PHOSPHATASE ; RESORPTION ; ALKALINE|
Objectives: Bone remodelling during orthodontic tooth movement is related to the expression of mediators in gingival crevicular fluid (GCF). No information is available concerning the effect of age on the levels of these mediators in GCE The purpose of this study was to quantify three mediators (prostaglandin E-2, interleukin-6 and grarmlocyte-Macrophage Colony-Stimulating Factor) in GCF during orthodontic tooth movement in juveniles and adults.
Material and methods: A total of 43 juvenile patients (mean age 11 +/- 0.7 year), and 41 adult patients (mean age 24 +/- 1.6 year) took part in the study. One of the lateral incisors of each patient was tipped labially, the other served as control. GCF samples were taken before force activation (t(0)) and 24 h later (t(24)). Mediator levels were determined by radioimmunoassay (RIA).
Results: PGE(2) concentrations were significantly elevated at t(24) in juveniles and adults, while concentrations of IL-6 and GM-CSF were significantly elevated only in juveniles. Total amounts of all three mediators in GCF significantly increased at t(24) in both groups.
Conclusions: In early tooth movement, mediator levels in juveniles are more responsive than levels in adults, which agrees with the finding that the initial tooth movement in juveniles is faster than in adults and starts without delay.
|作者单位||1.Beijing Med Univ, Dept Orthodont, Beijing, Peoples R China|
2.Univ Med Ctr St Radboud, Coll Dent Sci, Dept Orthodont & Oral Biol, NL-6500 HB Nijmegen, Netherlands
3.Univ Med Ctr St Radboud, Coll Dent Sci, Dept Prevent Dent & Cariol, NL-6500 HB Nijmegen, Netherlands
|Ren, YJ,Maltha, JC,van&prime,et al. Cytokine levels in crevicular fluid are less responsive to orthodontic force in adults than in juveniles[J]. JOURNAL OF CLINICAL PERIODONTOLOGY,2002,29(8):757-762.|
|APA||Ren, YJ.,Maltha, JC.,van&prime.,t Hof, MA.,Von den Hoff, JW.,...&Zhang, D.(2002).Cytokine levels in crevicular fluid are less responsive to orthodontic force in adults than in juveniles.JOURNAL OF CLINICAL PERIODONTOLOGY,29(8),757-762.|
|MLA||Ren, YJ,et al."Cytokine levels in crevicular fluid are less responsive to orthodontic force in adults than in juveniles".JOURNAL OF CLINICAL PERIODONTOLOGY 29.8(2002):757-762.|