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学科主题: 基础医学
题名:
Oxidative stress and metallothionein expression in the liver of rats with severe thermal injury
作者: Ding, HQ; Zhou, BJ; Liu, L; Cheng, S
关键词: severe thermal injury ; oxidative stress ; metallothionein ; glutathione ; glutathione-related enzymes ; zinc
刊名: BURNS
发表日期: 2002-05-01
卷: 28, 期:3, 页:215-221
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Critical Care Medicine ; Dermatology ; Surgery
研究领域[WOS]: General & Internal Medicine ; Dermatology ; Surgery
关键词[WOS]: GLUTATHIONE-PEROXIDASE ; INFLAMMATORY RESPONSE ; LIPID-PEROXIDATION ; GENE-EXPRESSION ; BURN INJURY ; IN-VIVO ; HEMOGLOBIN ; ELEMENTS ; CYTOKINE ; TISSUES
英文摘要:

The aim of this work was to study oxidative stress and the compensating mechanisms implicated in severe thermal injury using the burned rat model. Results showed that after thermal injury glutathione (GSH) level was decreased, oxidized glutathione (GSSG) and the ratio of GSSG/GSH increased both at 24 and 48 h in the liver. The activities of GSH-reductase (GSH-Rx) in the liver and GSH-peroxidase (GSH-Px) both in the liver and erythrocytes increased at 24 h and then decreased at 48 It. The level of a-tocopherol in plasma was reduced at 24 h. Lipid peroxide levels increased both at 24 and 48 h in the liver. The serum zinc level decreased, reaching a minimum at 12 h, whereas liver zinc level was elevated and reached the maximum at 12 h. After severe thermal injury enhancement of metallothionein (MT) expression has been discovered for the first time. NIT content in the liver increased both at 24 and 48 h. Expression of MT-I mRNA was activated at 3 h and reached the top at 24 h postburn. The conclusion is that severe thermal injury gives rise to oxidative stress and dramatic enhancement of MT expression could be one of the important compensative mechanisms of natural defense system postburn. (C) 2002 Elsevier Science Ltd and ISBI. All rights reserved.

语种: 英语
WOS记录号: WOS:000175972900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64670
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: Beijing Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100871, Peoples R China

Recommended Citation:
Ding, HQ,Zhou, BJ,Liu, L,et al. Oxidative stress and metallothionein expression in the liver of rats with severe thermal injury[J]. BURNS,2002,28(3):215-221.
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