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学科主题: 药学
题名:
Solid phase synthesis of peptide-siRNA conjugates containing disulfide bond unit
作者: Wang, Xiao-Feng; Yang, Xian-Tao; Chen, Yue; Liu, Yang; Zou, Lang; Yang, Zhen-Jun; Zhang, Li-He
关键词: siRNA ; Solid synthesis ; Disulfide bond ; Peptide ; Conjugate
刊名: CHINESE CHEMICAL LETTERS
发表日期: 2013-10-01
DOI: 10.1016/j.cclet.2013.06.010
卷: 24, 期:10, 页:873-876
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: CELL-PENETRATING PEPTIDES ; ANTISENSE OLIGONUCLEOTIDE ; DELIVERY ; PROGRESS ; VECTORS
英文摘要:

A disulfide-modified nucleoside was designed and synthesized. After loading the modified nucleoside on controlled pore glass (CPG), solid phase synthesis strategy was used to prepare peptide oligonucleotide conjugates (N-3′) containing disulfide bond unit. The 3′-sense strand peptide siRNA conjugate (VII) maintained good gene silencing activity, while that of the 3′-antisense strand conjugate decreased somewhat. And the sense strand off-target effect of VII decreased remarkably. (C) 2013 Zhen-Jun Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

语种: 英语
所属项目编号: 20932001 ; 2012CB720604 ; 2012AA022501
项目资助者: National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000324849300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64671
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Xiao-Feng,Yang, Xian-Tao,Chen, Yue,et al. Solid phase synthesis of peptide-siRNA conjugates containing disulfide bond unit[J]. CHINESE CHEMICAL LETTERS,2013,24(10):873-876.
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