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Solid phase synthesis of peptide-siRNA conjugates containing disulfide bond unit
Wang, Xiao-Feng; Yang, Xian-Tao; Chen, Yue; Liu, Yang; Zou, Lang; Yang, Zhen-Jun; Zhang, Li-He
关键词siRNA Solid synthesis Disulfide bond Peptide Conjugate
刊名CHINESE CHEMICAL LETTERS
2013-10-01
DOI10.1016/j.cclet.2013.06.010
24期:10页:873-876
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]CELL-PENETRATING PEPTIDES ; ANTISENSE OLIGONUCLEOTIDE ; DELIVERY ; PROGRESS ; VECTORS
英文摘要

A disulfide-modified nucleoside was designed and synthesized. After loading the modified nucleoside on controlled pore glass (CPG), solid phase synthesis strategy was used to prepare peptide oligonucleotide conjugates (N-3′) containing disulfide bond unit. The 3′-sense strand peptide siRNA conjugate (VII) maintained good gene silencing activity, while that of the 3′-antisense strand conjugate decreased somewhat. And the sense strand off-target effect of VII decreased remarkably. (C) 2013 Zhen-Jun Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

语种英语
WOS记录号WOS:000324849300004
项目编号20932001 ; 2012CB720604 ; 2012AA022501
资助机构National Natural Science Foundation of China ; Ministry of Science and Technology of China
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64671
专题北京大学药学院
北京大学医学部管理机构_后勤处
北京大学药学院_药物化学系
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xiao-Feng,Yang, Xian-Tao,Chen, Yue,et al. Solid phase synthesis of peptide-siRNA conjugates containing disulfide bond unit[J]. CHINESE CHEMICAL LETTERS,2013,24(10):873-876.
APA Wang, Xiao-Feng.,Yang, Xian-Tao.,Chen, Yue.,Liu, Yang.,Zou, Lang.,...&Zhang, Li-He.(2013).Solid phase synthesis of peptide-siRNA conjugates containing disulfide bond unit.CHINESE CHEMICAL LETTERS,24(10),873-876.
MLA Wang, Xiao-Feng,et al."Solid phase synthesis of peptide-siRNA conjugates containing disulfide bond unit".CHINESE CHEMICAL LETTERS 24.10(2013):873-876.
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