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Sulfur dioxide derivatives depress L-type calcium channel in rat cardiomyocytes
Zhang, Rong-Yuan1,5; Du, Jun-Bao1,4,5; Sun, Yan1; Chen, Stella6; Tsai, Hao-Jan2; Yuan, Lan5; Li, Lin2; Tang, Chao-Shu3,4; Jin, Hong-Fang1
关键词cardiomyocytes confocal microscopy intracellular calcium L-type calcium channels sulfur dioxide whole-cell patch-clamp
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
2011-07-01
DOI10.1111/j.1440-1681.2011.05528.x
38期:7页:366-372
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]CARDIAC MYOCYTES ; BLOOD-PRESSURE ; HEART
英文摘要

1. Sulfur dioxide (SO(2)) has recently been found to have various biological effects on the cardiovascular system. The present study was designed to explore the effects of SO(2) derivatives on the L-type calcium current (I (Ca, L)) in isolated rat ventricular cardiomyocytes.

2. A Langendorf system was used to dissociate single ventricular cells. SO(2) derivatives from 5 to 1000 mu mol/L were incubated with cardiomyocytes. The whole-cell patch-clamp technique was used to record I (Ca, L). The effect of SO(2) derivatives on intracellular calcium concentration ([Ca(2+)](i)) was detected by confocal microscopy.

3. Concentrations of 5 or 10 mu mol/L SO(2) derivatives could not change I (Ca, L) evoked by a single pulse from -40 to 0 mV for 200 ms in rat ventricular cardiomyocytes; however, 50, 100, 500 or 1000 mu mol/L SO(2) derivatives could depress the peak amplitudes of calcium currents in 6 min, and the I (Ca, L) was attenuated by 13.19%, 16.59%, 21.23% and 24.72%, respectively, as compared with corresponding controls (P < 0.05). The 50, 100, 500 or 1000 mu mol/L SO(2) derivatives also depressed the peak I-V curves, without altering the reversal potential and the voltage dependence of the peak I (Ca, L). Therefore, 1000 lmol/L SO(2) derivatives could reduce [Ca(2+)](i) in cardiomyocytes.

4. The results of the present study suggest that SO(2) derivatives can depress I (Ca, L) in cardiomyocytes, which might have a protective effect in cardiovascular diseases.

语种英语
WOS记录号WOS:000292100300003
项目编号2011CB503904 ; 30821001 ; 81070111 ; 7112130 ; 7082095
资助机构Major Basic Research Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64674
专题北京大学第一临床医学院_儿科
北京大学医学信息学中心
作者单位1.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Dept Cent Lab, Hosp 1, Beijing 100034, Peoples R China
3.Peking Univ, Inst Cardiovasc Res, Hosp 1, Beijing 100034, Peoples R China
4.Peking Univ, Key Lab Mol Cardiovasc Dis, Minist Educ, Beijing 100034, Peoples R China
5.Peking Univ, Lab Laser Scanning Confocal Microscope, Hlth Sci Ctr, Beijing 100034, Peoples R China
6.Univ Calif San Diego, Dept Biochem & Cellular Biol, San Diego, CA 92103 USA
推荐引用方式
GB/T 7714
Zhang, Rong-Yuan,Du, Jun-Bao,Sun, Yan,et al. Sulfur dioxide derivatives depress L-type calcium channel in rat cardiomyocytes[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2011,38(7):366-372.
APA Zhang, Rong-Yuan.,Du, Jun-Bao.,Sun, Yan.,Chen, Stella.,Tsai, Hao-Jan.,...&Jin, Hong-Fang.(2011).Sulfur dioxide derivatives depress L-type calcium channel in rat cardiomyocytes.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,38(7),366-372.
MLA Zhang, Rong-Yuan,et al."Sulfur dioxide derivatives depress L-type calcium channel in rat cardiomyocytes".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 38.7(2011):366-372.
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