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学科主题: 药学
题名:
Blockade of paeoniflorin on sodium current in mouse hippocampal CA(1) neurons
作者: Zhang, GQ; Hao, XM; Chen, SZ; Zhou, PA; Cheng, HP; Wu, CH
关键词: hippocampus ; patch-clamp techniques ; paeoniflorin ; sodium channels
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2003-12-01
卷: 24, 期:12, 页:1248-1252
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: LONG-TERM POTENTIATION ; PEONY ROOT ; MAJOR CONSTITUENT ; IMPAIRMENT ; DAMAGE
英文摘要:

AIM: To study the blockade of paeoniflorin (Pae) on I(Na) in the acutely isolated hippocampus neurons of mice. METHODS: The whole-cell patch clamp technique was used. RESULTS: Pae inhibited I(Na) in frequency-dependent and concentration-dependent manners, with an IC(50) of 271 mumol/L. Pae 0.3 mmol/L shifted the activation potential of the maximal I(Na) from -40 mV to -30 mV, shifted the steady-state activation and inactivation curves toward more positive and negative potentials by 10.8 mV, and 18.2 mV, respectively, and postponed the recovery of I(Na) inactivation state from (4.2 +/- 0.7) ms to (9.8 +/- 1.2) Ins. CONCLUSION: Pae inhibited I(Na) in mouse hippocampus neurons.

语种: 英语
WOS记录号: WOS:000187218600012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64675
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Tradit Chinese Med, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, GQ,Hao, XM,Chen, SZ,et al. Blockade of paeoniflorin on sodium current in mouse hippocampal CA(1) neurons[J]. ACTA PHARMACOLOGICA SINICA,2003,24(12):1248-1252.
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