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学科主题: 药物依赖
题名:
Interferon-alpha reinstates morphine-conditioned place preference through opioid receptors in rats
作者: Lang, Jun-Yuan1,2; Wang, Ji-Shi1,2; Zhai, Hai-Feng3; Fang, Qin1,2; Wu, Ping3; Lu, Lin3
关键词: conditioned place preference ; neuromodulator ; opioid receptors ; rat ; recombinant human interferon-alpha ; relapse
刊名: BEHAVIOURAL PHARMACOLOGY
发表日期: 2009-03-01
DOI: 10.1097/FBP.0b013e32832a805e
卷: 20, 期:2, 页:166-173
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: IMMUNOLOGICALLY INDUCED FATIGUE ; HUMAN-LEUKOCYTE INTERFERON ; CENTRAL-NERVOUS-SYSTEM ; FORCED SWIMMING TEST ; CHRONIC HEPATITIS-C ; MAINTENANCE TREATMENT ; DRUG REWARD ; BRAIN ; WITHDRAWAL ; EXPRESSION
英文摘要:

Cytokine interferon-alpha (IFN-alpha) is an immunomodulator and neuromodulator, which modulates central nervous system function partially by activating opioid receptors. However, the role that IFN-alpha plays in relapse to drug abuse is still largely unknown. Thus, we studied whether human recombinant INF-alpha (rIFN-alpha) would reinstate morphine-conditioned place preference (CPP) in rats. In Experiment 1, rats were trained for morphine-CPP with 8-day alternate subcutaneous (s.c.) injections of morphine and saline, and the effect of human IFN-alpha (20 000 IU/5 mu l, intracerebroventricularly) on CPP reinstatement was examined after extinction. In Experiment 2, rats underwent morphine (5 mg/kg, s.c.) unconditioned training with 8 daily alternate injections of morphine (5 mg/kg, s.c.) and saline. Then, the effect of human rIFN-alpha (20000 IU/5 mu l, intracerebroventricularly) on reinstatement of CPP was examined after extinction. In Experiment 3, the effect of opioid receptor antagonist naloxone (1 mg/kg, intraperitoneally) on human rIFN-alpha-induced reinstatement of morphine-CPP was investigated. We found that human rIFN-alpha reinstated morphine-CPP in rats trained under morphine conditioning after extinction, but did not affect CPP in rats that underwent unconditioned training. Naloxone significantly inhibited human rIFN-alpha-induced reinstatement of morphine-CPP. These results indicate that IFN-alpha is a stimulus for reinstatement of morphine-CPP by activation of opioid receptors, which extends our understanding on the high comorbidity of heroin relapse and viral infection. Behavioural Pharmacology 20:166-173 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 200703512302 ; 2006AA02Z4D1
项目资助者: National Basic Research Program of China ; National High Technology Research and Development Program of China
WOS记录号: WOS:000265561000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64678
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Guiyang Med Coll, Sch Pharmacol, Guiyang 550004, Peoples R China
2.Guiyang Med Coll, Affiliated Hosp, Guiyang 550004, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

Recommended Citation:
Lang, Jun-Yuan,Wang, Ji-Shi,Zhai, Hai-Feng,et al. Interferon-alpha reinstates morphine-conditioned place preference through opioid receptors in rats[J]. BEHAVIOURAL PHARMACOLOGY,2009,20(2):166-173.
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