北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 骨科  > 期刊论文
学科主题: 临床医学
题名:
Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury
作者: Xue, Guofang1; He, Meilan2; Zhao, Jie3; Chen, Yan3; Tian, Yun4; Zhao, Baozhen1; Niu, Bo3
关键词: mesenchymal stem cell ; nonunion ; peripheral nerve injury ; umbilical cord
刊名: REGENERATIVE MEDICINE
发表日期: 2011-11-01
DOI: 10.2217/RME.11.83
卷: 6, 期:6, 页:733-741
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell & Tissue Engineering ; Engineering, Biomedical
研究领域[WOS]: Cell Biology ; Engineering
关键词[WOS]: VERSUS-HOST-DISEASE ; JELLY-DERIVED CELLS ; STROMAL CELLS ; IMMUNE PROPERTIES ; RODENT MODEL ; BONE-MARROW ; RAT-BRAIN ; TRANSPLANTATION ; MATRIX ; DIFFERENTIATION
英文摘要:

Nonunion and nerve injury are the most severe and common complications of bone fracture treatments. There is still no ideal therapy for these two complications. In this report, we first applied umbilical cord mesenchymal stem cell (UC-MSC) therapy to one patient with both nonunion and nerve injury, and observed the therapeutic effects. UC-MSCs were produced and expanded according to a clinical-grade technique using serum-free medium enriched in human platelet lysate. Flow cytometry was performed to evaluate the purity of UC-MSCs, which were then intravenously injected. At 60 days postinjection, clinical examinations were performed to evaluate the therapeutic effects. Compared with before treatment, the patient′s nerve reflex was present, and their muscle tone and strength increased, and x-ray and electromyography ana-lysis further showed that the fracture gap disappeared and the nerve conduction velocity increased with shorter latency and higher amplitude. Furthermore, the clinical evolution was favorable and no side effects were observed during the 1-year follow-up. Overall, this novel treatment might open up a new strategy for the treatment of bone fracture complications.

语种: 英语
WOS记录号: WOS:000297200900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64679
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ So Calif, Dept Med, Los Angeles, CA USA
2.Shanxi Med Univ, Dept Endocrinol, Clin Med Coll 2, Taiyuan, Peoples R China
3.Shanxi Med Univ, Dept Biochem & Mol Biol, Taiyuan, Peoples R China
4.Peking Univ, Dept Orthoped, Affiliated Hosp 3, Beijing 100871, Peoples R China

Recommended Citation:
Xue, Guofang,He, Meilan,Zhao, Jie,et al. Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury[J]. REGENERATIVE MEDICINE,2011,6(6):733-741.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xue, Guofang]'s Articles
[He, Meilan]'s Articles
[Zhao, Jie]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xue, Guofang]‘s Articles
[He, Meilan]‘s Articles
[Zhao, Jie]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace