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学科主题临床医学
Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury
Xue, Guofang1; He, Meilan2; Zhao, Jie3; Chen, Yan3; Tian, Yun4; Zhao, Baozhen1; Niu, Bo3
关键词mesenchymal stem cell nonunion peripheral nerve injury umbilical cord
刊名REGENERATIVE MEDICINE
2011-11-01
DOI10.2217/RME.11.83
6期:6页:733-741
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell & Tissue Engineering ; Engineering, Biomedical
研究领域[WOS]Cell Biology ; Engineering
关键词[WOS]VERSUS-HOST-DISEASE ; JELLY-DERIVED CELLS ; STROMAL CELLS ; IMMUNE PROPERTIES ; RODENT MODEL ; BONE-MARROW ; RAT-BRAIN ; TRANSPLANTATION ; MATRIX ; DIFFERENTIATION
英文摘要

Nonunion and nerve injury are the most severe and common complications of bone fracture treatments. There is still no ideal therapy for these two complications. In this report, we first applied umbilical cord mesenchymal stem cell (UC-MSC) therapy to one patient with both nonunion and nerve injury, and observed the therapeutic effects. UC-MSCs were produced and expanded according to a clinical-grade technique using serum-free medium enriched in human platelet lysate. Flow cytometry was performed to evaluate the purity of UC-MSCs, which were then intravenously injected. At 60 days postinjection, clinical examinations were performed to evaluate the therapeutic effects. Compared with before treatment, the patient′s nerve reflex was present, and their muscle tone and strength increased, and x-ray and electromyography ana-lysis further showed that the fracture gap disappeared and the nerve conduction velocity increased with shorter latency and higher amplitude. Furthermore, the clinical evolution was favorable and no side effects were observed during the 1-year follow-up. Overall, this novel treatment might open up a new strategy for the treatment of bone fracture complications.

语种英语
WOS记录号WOS:000297200900010
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64679
专题北京大学第三临床医学院_骨科
作者单位1.Univ So Calif, Dept Med, Los Angeles, CA USA
2.Shanxi Med Univ, Dept Endocrinol, Clin Med Coll 2, Taiyuan, Peoples R China
3.Shanxi Med Univ, Dept Biochem & Mol Biol, Taiyuan, Peoples R China
4.Peking Univ, Dept Orthoped, Affiliated Hosp 3, Beijing 100871, Peoples R China
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GB/T 7714
Xue, Guofang,He, Meilan,Zhao, Jie,et al. Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury[J]. REGENERATIVE MEDICINE,2011,6(6):733-741.
APA Xue, Guofang.,He, Meilan.,Zhao, Jie.,Chen, Yan.,Tian, Yun.,...&Niu, Bo.(2011).Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury.REGENERATIVE MEDICINE,6(6),733-741.
MLA Xue, Guofang,et al."Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury".REGENERATIVE MEDICINE 6.6(2011):733-741.
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