IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心
学科主题临床医学
Paternal history of diabetes mellitus and hypertension affects the prevalence and phenotype of PCOS
Cheng, Chen1,2,3; Zhang, Haolin1,2,3; Zhao, Yue1,2,3; Li, Rong1,2,3; Qiao, Jie1,2,3
关键词Polycystic ovary syndrome (PCOS) Paternal history Diabetes mellitus Hypertension Phenotype
刊名JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
2015-12-01
DOI10.1007/s10815-015-0587-y
32期:12页:1731-1739
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
资助者National Key Technology RD Program ; National Key Technology RD Program
研究领域[WOS]Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]POLYCYSTIC-OVARY-SYNDROME ; HORMONE-BINDING GLOBULIN ; GENOME-WIDE ASSOCIATION ; METABOLIC SYNDROME ; FAMILY-HISTORY ; WOMEN ; CONSENSUS ; TESTOSTERONE ; OBESITY
英文摘要

The purpose of the present study is to determine if paternal or maternal history of diabetes mellitus (DM) and hypertension (HT) contributes to the prevalence and phenotype of polycystic ovary syndrome (PCOS).

We performed an epidemiologic study about PCOS from four districts in Beijing, China, between 2008 and 2009. Parental histories of DM and HT were collected, and the basic characteristics and serum indices of 123 PCOS patients and 718 non-PCOS controls were tested.

The prevalence of a parental history of DM and HT was significantly higher in PCOS patients than non-PCOS women (17.1 % vs. 9.2 % and 42.3 % vs. 26.0 %, P < 0.05, respectively). When paternal history was separated from maternal history, only a paternal history of DM and HT reached statistical significance between PCOS and non-PCOS patients (odds ratio (OR) = 3.42, 95 % confidence interval (CI) = 1.69-6.91; OR = 2.50, 95 % CI = 1.58-3.93, respectively). A paternal history of both DM and HT was significantly associated with sex hormone-binding globulin, fasting plasma glucose, and fasting insulin levels, the free androgen index, and the homeostatic model assessment-insulin resistance in PCOS patients (P < 0.05 for all). There was no independent association between maternal history and the clinical or biochemical phenotype of PCOS.

PCOS patients with a positive paternal history of both DM and HT have an adverse endocrine and metabolic profile. A paternal history of DM and HT poses a risk to PCOS.

语种英语
所属项目编号2007BAI04B04 ; 2012BAI32B01
资助者National Key Technology RD Program ; National Key Technology RD Program
WOS记录号WOS:000366643400005
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64681
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Reprod Med Ctr, Beijing 100871, Peoples R China
2.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Cheng, Chen,Zhang, Haolin,Zhao, Yue,et al. Paternal history of diabetes mellitus and hypertension affects the prevalence and phenotype of PCOS[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2015,32(12):1731-1739.
APA Cheng, Chen,Zhang, Haolin,Zhao, Yue,Li, Rong,&Qiao, Jie.(2015).Paternal history of diabetes mellitus and hypertension affects the prevalence and phenotype of PCOS.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,32(12),1731-1739.
MLA Cheng, Chen,et al."Paternal history of diabetes mellitus and hypertension affects the prevalence and phenotype of PCOS".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 32.12(2015):1731-1739.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Cheng, Chen]的文章
[Zhang, Haolin]的文章
[Zhao, Yue]的文章
百度学术
百度学术中相似的文章
[Cheng, Chen]的文章
[Zhang, Haolin]的文章
[Zhao, Yue]的文章
必应学术
必应学术中相似的文章
[Cheng, Chen]的文章
[Zhang, Haolin]的文章
[Zhao, Yue]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。