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Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism
Qian, QJ; Wang, YF; Zhou, RL; Li, J; Wang, B; Glatt, S; Faraone, SV
关键词attention deficit hyperactivity disorder catechol-O-methyltransferase association genetics gender differences
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2003-04-01
DOI10.1002/ajmg.b.10064
118B期:1页:103-109
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]CARDIO-FACIAL SYNDROME ; OBSESSIVE-COMPULSIVE DISORDER ; HAPLOTYPE RELATIVE RISK ; NO ASSOCIATION ; VAL ALLELE ; COMT ; SCHIZOPHRENIA ; POLYMORPHISM ; ADHD ; BEHAVIOR
英文摘要

Attention deficit hyperactivity disorder (ADHD) is the most common childhood-onset behavioral disorder. Boys are more often affected than girls. Family, twin, and adoption studies have supported a strong genetic basis. Some studies show that a catechol-O-methyltransferase (COMT) polymorphism affecting enzyme activity was associated with personality characteristics and diseases, such as novelty-seeking personality, substance abuse, and heroin addiction, whose features are similar to ADHD or are associated with ADHD. These findings suggest that the COMT gene may be a candidate gene for ADHD. TDT, HHRR, and case-control association studies were conducted within a sample of 202 nuclear ADHD families, 340 ADHD cases, and 226 controls in the Han Chinese population. Diagnoses and ADHD subtypes were ascertained according to DSM-IV criteria using American Clinical Diagnostic Interviewing Scales. The HHRR analysis suggested that the low enzyme-activity COMT Met allele was preferentially transmitted to ADHD boys (160 trios, chi(2) = 3.858, P = 0.05, df =1) but not girls. This association is particularly pronounced among male ADHD probands without any comorbidity (50 trios, HHRR: chi(2) = 5.128, P = 0.024, df =1; TDT: chi(2) = 4.558, P = 0.033, df = 1), especially the ADHD-I subtype (32 trios, HHRR: chi(2) = 5.792, P = 0.016, df =1; TDT: chi(2) = 5.333, P = 0.021, df =1). The case-control study revealed that the Val allele was more frequent in females meeting ICD-10 or DSM-IV criteria for ADHD than in female controls (86 and 79.5%, respectively, chi(2) = 4.059, P = 0.044, df =1). Although these results suggest the COMT gene exerts some influence on the risk for ADHD in the Han Chinese population, given the potential for Type I error, these findings require replication before drawing definitive conclusions. (C) 2003 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000182401800020
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被引频次:87[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64684
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr, Dept Psychiat, Boston, MA 02115 USA
3.Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
4.Massachusetts Gen Hosp, Psychiat Serv, Boston, MA 02114 USA
5.Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA
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Qian, QJ,Wang, YF,Zhou, RL,et al. Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2003,118B(1):103-109.
APA Qian, QJ.,Wang, YF.,Zhou, RL.,Li, J.,Wang, B.,...&Faraone, SV.(2003).Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,118B(1),103-109.
MLA Qian, QJ,et al."Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 118B.1(2003):103-109.
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