IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
MicroRNA-188 suppresses G(1)/S transition by targeting multiple cyclin/CDK complexes
Wu, Jiangbin1,2; Lv, Qing1,2; He, Jie2; Zhang, Haoxiang1,2; Mei, Xueshuang3; Cui, Kai1,2; Huang, Nunu1,2; Xie, Weidong2; Xu, Naihan2; Zhang, Yaou2
关键词MiR-188 Cell cycle G(1)/S transition CDK Cyclin Rb E2F
刊名CELL COMMUNICATION AND SIGNALING
2014-10-11
DOI10.1186/s12964-014-0066-6
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]HUMAN BREAST-CANCER ; CELL-CYCLE ARREST ; LARGE GENE LISTS ; ENERGY HOMEOSTASIS ; STEM-CELLS ; EXPRESSION ; DIFFERENTIATION ; PROLIFERATION ; CARCINOMAS ; D1
英文摘要

Background: Accelerated cell cycle progression is the common feature of most cancers. MiRNAs can act as oncogenes or tumor suppressors by directly modulating cell cycle machinery. It has been shown that miR-188 is upregulated in UVB-irradiated mouse skin and human nasopharyngeal carcinoma CNE cells under hypoxic stress. However, little is known about the function of miR-188 in cell proliferation and growth control.

Results: Overexpression of miR-188 inhibits cell proliferation, tumor colony formation and G1/S cell cycle transition in human nasopharyngeal carcinoma CNE cells. Using bioinformatics approach, we identify a series of genes regulating G1/S transition as putative miR-188 targets. MiR-188 inhibits both mRNA and protein expression of CCND1, CCND3, CCNE1, CCNA2, CDK4 and CDK2, suppresses Rb phosphorylation and downregulates E2F transcriptional activity. The expression level of miR-188 also inversely correlates with the expression of miR-188 targets in human nasopharyngeal carcinoma (NPC) tissues. Moreover, studies in xenograft mouse model reveal that miR-188 is capable of inhibiting tumor initiation and progression by suppressing target genes expression and Rb phosphorylation.

Conclusions: This study demonstrates that miR-188 exerts anticancer effects, via downregulation of multiple G1/S related cyclin/CDKs and Rb/E2F signaling pathway.

语种英语
WOS记录号WOS:000346522700001
项目编号81261120556 ; 31100976 ; JCYJ20120616213930060 ; 2013 M530604
资助机构National Natural Science Foundation of China ; Canadian Institutes of Health Research ; National Natural Science Foundation of China ; Basic Research Grant of Shenzhen ; China Postdoctoral Science Foundation
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64687
专题北京大学深圳医院
作者单位1.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
2.Tsinghua Univ, Grad Sch Shenzhen, Key Lab Healthy Sci & Technol, Div Life Sci, Shenzhen 518055, Peoples R China
3.Peking Univ, Shenzhen Hosp, ENT Dept, Shenzhen 518055, Peoples R China
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GB/T 7714
Wu, Jiangbin,Lv, Qing,He, Jie,et al. MicroRNA-188 suppresses G(1)/S transition by targeting multiple cyclin/CDK complexes[J]. CELL COMMUNICATION AND SIGNALING,2014,12.
APA Wu, Jiangbin.,Lv, Qing.,He, Jie.,Zhang, Haoxiang.,Mei, Xueshuang.,...&Zhang, Yaou.(2014).MicroRNA-188 suppresses G(1)/S transition by targeting multiple cyclin/CDK complexes.CELL COMMUNICATION AND SIGNALING,12.
MLA Wu, Jiangbin,et al."MicroRNA-188 suppresses G(1)/S transition by targeting multiple cyclin/CDK complexes".CELL COMMUNICATION AND SIGNALING 12(2014).
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