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A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis
Wang, M; Xing, ZM; Lu, C; Ma, YX; Yu, DL; Yan, Z; Wang, SW; Yu, LS
刊名HUMAN GENETICS
2003-10-01
DOI10.1007/s00439-003-1001-x
113期:5页:387-390
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]INTERLEUKIN-13 GENE ; CODING REGION ; ASTHMA ; ASSOCIATION ; DERMATITIS ; CHILDREN ; VARIANT ; LEVEL
英文摘要

Allergic rhinitis is a major public health problem and has seen its prevalence increase during the past few decades. Interleukin 13 (IL-13) has been implicated in the pathogenesis and in the regulation of immunoglobulin E (IgE) production. Single nucleotide polymorphisms (SNPs) have been found in both the coding sequence and the promoter region of IL-13, and such SNPs have been associated with allergic asthma. We have investigated whether IL-13 SNPs are associated with allergic rhinitis. Among 188 Chinese adult patients with allergic rhinitis and 87 normal controls, no significant difference was found in either allele or haplotype frequency of the SNPs between the two groups. Within patients, there was a significant association of the IL-13 Arg130Gln SNP, but not of the IL-13 promoter -1112(C/T) SNP, with serum total IgE levels. Patients with a Gln/Gln genotype showed much higher serum total IgE than those with an Arg/Arg genotype. When tested for serum-specific IgE, patients allergic to Derp 1, but not those allergic to Artemisia pollen, showed a significant association with the IL-13 promoter SNP. Thus, our results suggest a possible involvement of IL-13 SNPs in the regulation of IgE production in response to allergens in this Chinese population.

语种英语
WOS记录号WOS:000185346700004
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被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64689
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept ENT, Beijing 100044, Peoples R China
2.Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1X8, Canada
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GB/T 7714
Wang, M,Xing, ZM,Lu, C,et al. A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis[J]. HUMAN GENETICS,2003,113(5):387-390.
APA Wang, M.,Xing, ZM.,Lu, C.,Ma, YX.,Yu, DL.,...&Yu, LS.(2003).A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis.HUMAN GENETICS,113(5),387-390.
MLA Wang, M,et al."A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis".HUMAN GENETICS 113.5(2003):387-390.
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