北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Local administration of IKK small molecule inhibitor may enhance fracture healing in osteoporosis patient
作者: Han, Duanyang; Zhang, Peixun; Jiang, Baoguo
关键词: IKK inhibitor ; osteoporosis ; fracture healing ; NF-kappa B signaling
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2015
卷: 8, 期:1, 页:1411-1415
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: FACTOR-KAPPA-B ; MESENCHYMAL STEM-CELLS ; BONE-MARROW ; OSTEOGENIC DIFFERENTIATION ; ESTROGEN DEFICIENCY ; IMMUNE-SYSTEM ; OLDER WOMEN ; RATS ; AGE ; DENSITY
英文摘要:

Osteoporosis is an inflammatory bone disease affecting millions of population worldwide, which often cause increased fracture risks and prolonged fracture healing. Growing evidence suggests that IKK-NF-kappa B signaling exert inhibitory influence on MSCs osteogenic differentiation and bone formation. Moreover, enhance the fracture healing process in osteoporosis patient. In the current work, IKK-NF-kappa B differentiated osteoblasts. Thus, manipulating local inflammatory IKK-NF-kappa B signaling was also found to suppress the anabolic effect of signaling in osteoporotic related fracture emerge as a promising therapy to we hypothesized to use locally delivered IKK small molecule inhibitor to augment the impaired fracture healing ability in osteoporosis patient via enhancing both MSCs osteogenic differentiation and osteoblast function.

语种: 英语
所属项目编号: 2014CB542200 ; IRT1201 ; 31271284 ; 31171150 ; 81171146 ; 31471144 ; 3097-1526 ; 31100860 ; 31040043 ; 31371210 ; 81372044 ; BMU20110270 ; 7142164
项目资助者: Chinese National Ministry of Science and Technology 973 Project Planning ; ministry of education innovation team ; Na-tional Natural Science Fund ; Educational Ministry New Century Excellent Talents Support Project ; Beijing Natural Science Foundation
WOS记录号: WOS:000349897200180
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64690
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Peoples Hosp, Dept Orthoped & Trauma, Beijing, Peoples R China

Recommended Citation:
Han, Duanyang,Zhang, Peixun,Jiang, Baoguo. Local administration of IKK small molecule inhibitor may enhance fracture healing in osteoporosis patient[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2015,8(1):1411-1415.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Han, Duanyang]'s Articles
[Zhang, Peixun]'s Articles
[Jiang, Baoguo]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Han, Duanyang]‘s Articles
[Zhang, Peixun]‘s Articles
[Jiang, Baoguo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace